펄스차이 폴라로그래피를 이용한 갑상선기능조절 약제 중의 2-mercapto-1-methyl-imidazole 분석
Analysis of 2-Mercapro-1-Methylimidazole in Controlling Drug of Thyroid by Differential Pulse Polarography
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
5.0×10−2 M LiClO4 지지전해질에서 2-mercapto-1-methyl-imidazole(MMI)의 분석을 펄스차이폴라로그래피로 조사하였다. MMI의 분석에서 적절한 조건은 다음과 같다; 초기전위: -0.9 volts, 펄스세기: 0.08 mV, 주사속도: 2 mV/sec. 표준검량곡선은 1.0×10−7~8.0×10−5 M 범위에서 좋은 직선성을 보였으며, 검출한계는 (2.2 ± 0.1) × 0.1−9 M이었다. 이 방법으로 첨가제의 방해없이 항갑상선 약제중의 MMI를 정량하는데 응용하였다.
Abstract
The determination of 2-mercapto-1-methyl-imidazole (MMI) in 5.0×10−2 M lithium perchlorate suporting electrolyte has been investigated by the differential pulse polarography. The optimum condition of MMI analysis was as follows; -0.9 volts initial potential, 0.08 mV pulse height, 2 mV/sec scan rate, and medium mercury drop size. Standard calibration curve showed a good linearlity in the range of 1.0×10−7 M to 8.0×10−5 M and the detection limit has been (2.2 ± 0.1) × 0.1−9 M. This method was applicated for the determination of MMI in antithyroid drug without interference of additives.
참고문헌 (6)
- "Principle of Biochemistry", pp.~796 (1982), Worth PublishersInc.
- "J. J. of Chromatog-raphy", pp.405~ (1976)
- "D. J. of Chromatography", pp.267~ (1978)
- "R.C. CRC Handbook of Chemistry and physics", pp.~145 (1987), CRC press
- "P. The Elucidation of Organic Electrode Process" (1969), Academic Press
- "A. Encyclopedia of Electrochemistry of the Elements", xii, pp.411~ (1973), Marcel Dekker Inc.