본문 바로가기
KERD
논문KCI 등재

Design, Synthesis and Spectral Characterization of Novel 2-morpholino-N-(4,6-diarylpyrimidin-2-yl)acetamides

Vijayakumar Kanagarajan|Jayaraman Thanusu|Mannathusamy Gopalakrishnan
대한화학회|2010.02|대한화학회지 (Journal of the Korean Chemical Society)|제54권 제1호|pp. 49-54

2

조회

0

다운로드

0

인용

0

참고문헌

키워드

Synthesis42-Morpholino-N-(46-diarylpyrimidin-2-yl)acetamides6-Diarylpyrimidin-2-aminesChloroacetylationMorpholine2-Chloro-N-(4모르포린클로로아세틸화반응
주제분류화학

초록

A new series of novel 2-morpholino-N-(4,6-diarylpyrimidin-2-yl)acetamides 34-42 is synthesized by the condensation of 2-chloro-N-(4,6-diarylpyrimidin-2-yl)acetamides 25-33 with morpholine in the presence of anhydrous potassium carbonate. The synthesized compounds have been characterized by melting point, elemental analysis, MS, FT-IR, one-dimensional NMR (1H & 13C) spectroscopic data.

Abstract

A new series of novel 2-morpholino-N-(4,6-diarylpyrimidin-2-yl)acetamides 34-42 is synthesized by the condensation of 2-chloro-N-(4,6-diarylpyrimidin-2-yl)acetamides 25-33 with morpholine in the presence of anhydrous potassium carbonate. The synthesized compounds have been characterized by melting point, elemental analysis, MS, FT-IR, one-dimensional NMR (1H & 13C) spectroscopic data.

참고문헌 (33)

  1. Mercer, F. L., , Commoner, B. Science, 117, pp.558~ (1953)
  2. Matolesy, G., , World Rev. Pest. Contr., 10, pp.50~ (1971)
  3. Weishaar, R. E., , J. Med. Chem., 42, pp.805~ (1999)
  4. Commoner, B., , Nature, 168, pp.113~ (1951)
  5. Ram, V. J., , Eur. J. Med. Chem., 25, pp.549~555 (1990)
  6. Ahluwalia, V. K., , Indian J. Chem., 28B, pp.964~ (1989)
  7. Tam, S. W., , Eur. J. Med. Chem., 42, pp.809~ (1999)
  8. Goyal, R. N., , J. Indian Chem. Soc., 62, pp.229~ (1985)
  9. Hamilton, D. J., , Tetrahedron Lett., 45, pp.5739~ (2004)
  10. Akyuz, S., , J. Mol. Struct., 744, pp.881~ (2005)
  11. Akyuz, S., , J. Mol. Struct., 651, pp.205~ (2003)
  12. Chauhan, D., , Indian J. Chem., 40B, pp.524~ (2001)
  13. Kushner, S., , J. Org. Chem., 16, pp.1283~ (1951)
  14. Kochetkov, N. K., , J. Gen. Chem. USSR, 26, pp.2915~ (1951)
  15. Kochetkov, N. K., , J. Gen. Chem. USSR, 32, pp.1481~ (1957)
  16. Eregowda, G. B., , Indian J. Chem., 39B, pp.243~ (2000)
  17. Al-Haiza, M. A., , Molecules, 8, pp.275~ (2003)
  18. Gan, J., , Proc. Natl. Acad. Sci. U.S.A., 99, pp.5189~ (2002)
  19. Hasan, S. J., , Indian J. Chem., 9, pp.1022~ (1971)
  20. Marouka K, "Comprehensive Organic Synthesis", pp.6221~ (1991), Trost B M. Pergamonn Press
  21. Manfred, R., "Eur. Pat. Appl. EP 1989, 334146, 28. Chem. Abstr. 1989, 112, 178999", ~ (1989)
  22. Manfred, R., "Ger. Offen. DE 1989, 3729285, 17. Chem. Abstr. 1989, 111, 134172", ~ (1989)
  23. Hale, J. J., , J. Med. Chem., 43, pp.1234~ (2000)
  24. Dorn, C. P., "US Patent 1997, 5691336, 82. Chem. Abstr. 1979, 128, 48231", ~ (1997)
  25. Fisher, M. H., "U. S. Patent 1991, 5077290, 10. Chem. Abstr. 1991, 116, 214513", ~ (1991)
  26. Avramova, P., , Arch. Pharm., 331, pp.342~ (1998)
  27. Gopalakrishnan, M, , Lett. Org. Chem., 5, pp.142~ (2008)
  28. Gopalakrishnan, M., , J. Enz. Inhib. Med. Chem., 23, pp.347~ (2008)
  29. Gopalakrishnan, M., , Med. Chem. Res., 16, pp.392~ (2007)
  30. Gopalakrishnan, M., , J. Enz. Inhib. Med. Chem., 22, pp.709~ (2007)
  31. Guthrie, W., , Can. J. Chem., 69, pp.339~ (1991)
  32. Kothari, S., , J. Indian Chem. Soc., 77, pp.329~ (2000)
  33. Speziale, A. J., , J. Am. Chem. Soc., 78, pp.2556~ (1956)

관련 논문AI추천

Synthesis and Characterization of Novel Oxadiazole Derivatives from BenzimidazoleBalasubramanaya Vishwanathan, Bannimath Gurupadayya대한화학회 · 대한화학회지2014 · 제58권 제5호Synthesis and Biological Evaluation of Novel Isopropyl 2-thiazolopyrimidine-6-carboxylate DerivativesC. V. Rao, K. Naga Raju, N. Hari Krishna, S. B. Jonnalagadda, Suresh Maddila, Y. Kotaiah대한화학회 · 대한화학회지2012 · 제56권 제1호Synthesis and Biological Evaluation of Some Novel [4-(1H-Benzoimidazol-2-yl)-thiazol-2-yl]-benzylidene-amines and N-[4-(1H-Benzoimidazol-2-yl)-thiazol-2-yl]-N’-benzylidene-hydrazinesHemalatha Gadegoni, Raghu Vardhan Reddy Mekala, Ravinder Reddy Danda대한화학회 · 대한화학회지2013 · 제57권 제1호Synthesis of Some New Condensed Pyrimidine DerivativesEnaiat K. Mohamed, Wesam S. Shehab대한화학회 · 대한화학회지2011 · 제55권 제6호A Green Chemical Approach towards the ‘One-Pot’ Synthesis, Spectral Characterization and in Vitro Antibacterial and Antifungal Activities of Morpholino PyrimidinesJ. Thanusu, M. Gopalakrishnan, V. Kanagarajan대한화학회 · 대한화학회지2009 · 제53권 제6호Synthesis of Pyrimidines and Heteroannulated Pyrimidine Ring SystemsF. K. Mohammed, M. G. Badrey대한화학회 · 대한화학회지2011 · 제55권 제2호

이 간행물의 다른 논문 (27건)

Synthesis of 7-Methyl-3-(2/-oxo-2H-benzopyran-6/-yl)-5H-1,4-thiazolo-[3,2-a]pyrimidin-5-one and Its DerivativesVinata .V. Mulwad, Hitesh .T. Parmar, Abid Ali Mirpp. 9-12Photophysical Parameters, Photodecomposition, Fluorescence Quenching and Convolutive Voltammetry of 7-Diethylaminocoumarin (DEAC) Laser DyeI. S. El-Hallag, S. A. El-Dalypp. 13-22Synthesis, Chemical Characterization and Catalytic Activity of Transition Metal Complexes Having Imine Based Nitrogen Donor LigandAmin Badshah, Maliha Asma, Raja Azadar Hussainpp. 23-26백금/니켈 촉매를 이용한 1,1’-Bis(dimethylhydrosilyl)ferrocene과 Alkynes, Alkenes의 선택적 Hydrosilyation 반응김진식, 공영건pp. 27-37Analysis of Matrine Alkaloids in Human Urine by Hollow Fiber Liquid-phase Microextraction with High-performance Liquid Chromatography한단단, 노경호pp. 38-42
원문 보기