Novel Synthesis of bis Acetylated Hybrid Pyrazoles as Potent Anticandidiasis Agents
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A new series of bis acetylated hybrid pyrazoles were synthesized and characterized by their melting point, elemental analysis, MS, FT-IR, one-dimensional ^1H, and ^(13)C NMR spectroscopic data. All the synthesized compounds were tested for their in vitro antifungal activities against Candida sp. namely Candida albicans, Candida glabrata, Candida parapsilosis,Candida dubliniensis and Candida tropicalis. A close inspection of the in vitro anticandidal activity profile in differently electron donating (CH_3 and OCH_3) and electron withdrawing (-F, -Cl, and Br) functional group substituted phenyl rings of novel hybrid pyrazoles exerted strong anticandidal activity against all the tested Candida species.
Abstract
Bis acetylated hybrid pyrazoles 을 합성하여 이들 화합물에 대해 녹는점, 원소분석, MS, FT-IR, one-dimensional ^1H,- 및 ^(13)C-NMR로 분석하였다. 합성한 화합물들에 대해 in vitro 항균활성을 Candida sp. namely Candida albicans,Candida glabrata, Candida parapsilosis, Candida dubliniensis 및 Candida tropicali 균에 대해 수행하였다. Pyrazoles의 페닐고리에 작용기(-CH_3, -OCH_3, -F, -Cl, 및 Br)가 있는 화합물은 Candida species에 대해서 강한 활성을 나타내었다.
참고문헌 (26)
- Zhang, X. H., , Thin Solid Films, 371, pp.40~ (2000)
- Ramalingham, K., , J. Med. Chem, 20, pp.847~ (1977)
- Korgaokar, S. S., , Indian J. Pharm. Sci, 58, pp.222~ (1996)
- Rajendra, P. Y., , Bioorg. Med. Chem. Lett, 15, pp.5030~ (2005)
- Lombardino, J. G., , J. Med. Chem, 24, pp.830~ (1981)
- Ozdemir, Z., , Eur. J. Med. Chem, 42, pp.373~ (2007)
- Taylor, E. C., , Tetrahedron, 48, pp.8089~ (1992)
- Budakoti, A., , Eur. J. Med. Chem, 41, pp.63~ (2006)
- Zitouni, G. T., , Arch. Pharm. (Weinheim), 338, pp.96~ (2005)
- Fathalla, O. A., , Acta Pol. Pharm, 60, pp.51~ (2003)
- Luche, J. L., "Synthetic Organic Chemistry" (1998), Plenum Press
- Mason, T. J., "Practical Sonochemistry" (1991), Ellis Harwood Ltd
- Odds, F.C., , J. Antimicrob. Chemother, 31, pp.463~ (1993)
- Johnson, E. M., , J. Antimicrob. Chemother, 35, pp.103~ (1995)
- Rex, J. H., , Antimicrob. Agents Chemother, 39, pp.1~ (1995)
- Pappas, P. G., , Infect. Dis. Clin. North Am, 20, pp.485~ (2006)
- Thanusu, J., , Bioorg. & Med. Chem. Lett, 20, pp.713~ (2010)
- V. Kanagarajan, "A Green Chemical Approach towards the ‘One-Pot’ Synthesis, Spectral Characterization and in Vitro Antibacterial and Antifungal Activities of Morpholino Pyrimidines", 대한화학회지, 53(6), pp.731~741 (2009), 대한화학회
- Gopalakrishnan, M., , Enz. Inhib. Med. Chem, 24, pp.1088~ (2009)
- Gopalakrishnan, M., , J. Enz. Inhib. Med. Chem, 24, pp.406~ (2009)
- Mason, T. J., "Applied Sonochemistry: The uses of power Ultrasound in chemistry and processing" (2002), Wiley-VCH
- Baldwin, J. E., , J. Chem.. Soc, pp.734~ (1976)
- Guthrie, W., , Can. J. Chem, 69, pp.339~ (1991)
- Dhar, M. H., , Indian J. Exp. Biol, 6, pp.232~ (1968)
- Lipinski, C. A., , J. Adv. Drug Deliver. Rev, 23, pp.3~ (1997)
- Purser, S., , Chem. Soc. Rev, 37, pp.320~ (2008)