카할세포 결핍과 연관된 미숙아 가성 장폐쇄 1례
Neonatal Intestinal Pseudo-obstruction Associated with Deficiency of the Interstitial Cells of Cajal in a Premature Infant
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
The interstitial cells of Cajal are the pacemakers in the gastrointestinal tract that modulate gastrointestinal motility. A case of a neonate with intestinal pseudo-obstruction caused by a decreased number of the interstitial cells of Cajal is presented. A premature male infant born at 32 weeks of gestation showed progressive abdominal distention beginning 3 days after initiation of enteral feeding at 15 days of life. No etiologic factors were identified on radiologic studies, a gastrographin enema, and an intestinal biopsy other than a markedly decreased number of the intestinal cells of Cajal. An ileostomy, followed by repair of the ileostomy was done, which resulted in but a limited improvement of the abdominal gas pattern. Respiratory distress, pancytopenia, and abdominal distention persisted, and the infant expired on 142 days of life.
Abstract
The interstitial cells of Cajal are the pacemakers in the gastrointestinal tract that modulate gastrointestinal motility. A case of a neonate with intestinal pseudo-obstruction caused by a decreased number of the interstitial cells of Cajal is presented. A premature male infant born at 32 weeks of gestation showed progressive abdominal distention beginning 3 days after initiation of enteral feeding at 15 days of life. No etiologic factors were identified on radiologic studies, a gastrographin enema, and an intestinal biopsy other than a markedly decreased number of the intestinal cells of Cajal. An ileostomy, followed by repair of the ileostomy was done, which resulted in but a limited improvement of the abdominal gas pattern. Respiratory distress, pancytopenia, and abdominal distention persisted, and the infant expired on 142 days of life.
참고문헌 (18)
- Park KJ, "Interstitial cells of Cajal and GI motility", Korean J Gastrointest Motil, 10, pp.93~99 (2004)
- Lamireau T, "Transient intestinal pseudo-obstruction syndrome in premature infants", Arch Fr Pediatr, 50, pp.301~306 (1993)
- Kenny SE, "Delayed maturation of the interstitial cells of Cajal: a new diagnosis for transient neonatal pseudo-obstruction. Report of two cases", J Pediatr Surg, 33, pp.94~98 (1998)
- Faussone-Pellegrini MS, "Midrio P. Morphology of the interstitial cells of Cajal of the human ileum from foetal to neonatal life", J Cell Mol Med, 11, pp.482~494 (2007)
- Sanders KM, "A case for interstitial cells of Cajal as pacemakers and mediators of neurotransmission in the gastrointestinal tract", Gastoenterology, 111, pp.492~515 (1996)
- Maeda H, "Requirement of c-kit for development of intestinal pacemaker system", Development, 116, pp.369~375 (1992)
- Yamataka A, "Intestinal pacemarker C-KIT+cells and synapses in allied Hirschsprung's disorders", J Pediatr Surg, 32, pp.1069~1074 (1997)
- Kenny SE, "Abnormal colonic interstitial cells of Cajal in children with anorectal malformations", J Pediatr Surg, 33, pp.130~132 (1998)
- Yamataka A, "Abnormal distribution of intestinal pacemaker(C-KIT-positive) cells in an infant with chronic idiopathic intestinal pseudoobstruction", J Pediatr Surg, 33, pp.859~862 (1998)
- He CL, "Decreased interstitial cell of Cajal volume in patients with slowtransit constipation", Gastroenterology, 118, pp.14~21 (2000)
- Jeng YM, "Congenital interstitial cell of Cajal hyperplasia with neuronal intestinal dysplasia", Am J Surg Pathol, 24, pp.1568~1572 (2000)
- Porcher C, "Deficiency of interstitial cells of Cajal in the small intestine of patients with Crohn's disease", Am J Gastroenterol, 97, pp.118~125 (2002)
- Vanderwinden JM, "Study of the interstitial cells of Cajal in infantile hypertrophic pyloric stenosis", Gastroenterology, 111, pp.279~288 (1996)
- Kindblom LG, "Gastrointestinal pacemaker cell tumor (GIPACT): gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal", Am J Pathol, 152, pp.1259~169 (1998)
- Yun KB, "A case of gastrointestinal stromal tumor in a child", Korean J Pediatr Gastroenterol Nutr, 10, pp.71~75 (2007)
- Midrio P, "Faussone-Pellegrini MS. Delayed development of interstitial cells of Cajal in the ileum of a human case of gastroschisis", J Cell Mol Med, 12, pp.471~478 (2008)
- Kenny SE, "Ontogeny of interstitial cells of Cajal in the human intestine", J Pediatr Surg, 34, pp.1241~1247 (1999)
- Vanderwinden JM, "Interstitial cells of Cajal in human colon and in Hirschsprung's disease", Gastroenterology, 111, pp.901~910 (1996)