Clinical Implication of Surgically treated Abdominoperineal Soild Tumor in the Newborn : A Single-Center Experience
5
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Purpose: Abdominoperineal solid tumors presenting in neonates often require surgical intervention during the neonatal period. Although we report our single-center experience, this study would be meaningful to understand the clinical implications of these neoplasms. Methods: We retrospectively reviewed and analyzed the clinical data and characteristics of 22 patients (≤28 days old) diagnosed with histopathologically confirmed abdominoperineal solid neoplasms (benign or malignant) after surgical resection. Results: The mean gestational age and postnatal age at the time of operation were 38.3±1.8 weeks and 13.5±8.3 days, respectively. Most patients (18/22, 81.8%) were diagnosed during antenatal care visits; however, 4 (18.2%) were identified after birth. The mean tumor size was 6.4×5.3 cm (3.5–17.0 cm), and tumors occurred most frequently within the sacrococcygeal region (8/22, 36.4%). Histopathologically, 14 patients (63.6%) demonstrated benign tumors and 8 (36.4%) demonstrated malignant tumors. Germ cell tumors and hepatoblastomas were the most commonly observed tumors. Fortunately, all patients showed a localized pattern of tumor involvement without distant metastasis. No recurrence or mortality was observed during the follow-up period (mean 66.4±44.2 months). Conclusion: Abdominoperineal solid tumors occurring in neonates show variable clinical patterns during the antenatal and postnatal monitoring/screening periods. We conclude that aggressive and multidisciplinary approaches could achieve good clinical results in these patients.
Abstract
Purpose: Abdominoperineal solid tumors presenting in neonates often require surgical intervention during the neonatal period. Although we report our single-center experience, this study would be meaningful to understand the clinical implications of these neoplasms. Methods: We retrospectively reviewed and analyzed the clinical data and characteristics of 22 patients (≤28 days old) diagnosed with histopathologically confirmed abdominoperineal solid neoplasms (benign or malignant) after surgical resection. Results: The mean gestational age and postnatal age at the time of operation were 38.3±1.8 weeks and 13.5±8.3 days, respectively. Most patients (18/22, 81.8%) were diagnosed during antenatal care visits; however, 4 (18.2%) were identified after birth. The mean tumor size was 6.4×5.3 cm (3.5–17.0 cm), and tumors occurred most frequently within the sacrococcygeal region (8/22, 36.4%). Histopathologically, 14 patients (63.6%) demonstrated benign tumors and 8 (36.4%) demonstrated malignant tumors. Germ cell tumors and hepatoblastomas were the most commonly observed tumors. Fortunately, all patients showed a localized pattern of tumor involvement without distant metastasis. No recurrence or mortality was observed during the follow-up period (mean 66.4±44.2 months). Conclusion: Abdominoperineal solid tumors occurring in neonates show variable clinical patterns during the antenatal and postnatal monitoring/screening periods. We conclude that aggressive and multidisciplinary approaches could achieve good clinical results in these patients.
참고문헌 (33)
- Moore SW, "The epidemiology of neonatal tumours. Report of an international working group", Pediatr Surg Int, 19, pp.509~519 (2003)[DOI]
- Halperin EC, "Neonatal neoplasms", Int J Radiat Oncol Biol Phys, 47, pp.171~178 (2000)[DOI]
- Orbach D, "Neonatal cancer", Lancet Oncol, 14, pp.e609~e620 (2013)[DOI]
- Vormoor J, "Leukaemia & cancer in neonates", Semin Fetal Neonatal Med, 17, pp.183~184 (2012)[DOI]
- Lee TC, "Evaluation of the prenatally diagnosed mass", Semin Fetal Neonatal Med, 17, pp.185~191 (2012)[DOI]
- Parkes SE, "Neonatal tumours: a thirty-year population-based study", Med Pediatr Oncol, 22, pp.309~317 (1994)[DOI]
- Willis RA, "The borderland of embryology and pathology", pp.422~466 (1962), Butterworths
- Spector LG, "Cancer risk among children with very low birth weights", Pediatrics, 124, pp.96~104 (2009)[DOI]
- Desandes E, "Neonatal solid tumors: incidence and survival in France", Pediatr Blood Cancer, 63, pp.1375~1380 (2016)[DOI]
- Gurney JG, "Incidence of cancer in children in the United States: sex-race-and 1-year agespecific rates by histological type", Cancer, 75, pp.2186~2195 (1995)[DOI]
- Lichtenstein P, "Environmental and heritable factors in the causation of cancer--analyses of cohorts of twins from Sweden, Denmark and Finland", N Eng J Med, 343, pp.78~85 (2000)[DOI]
- Doll R, "Risk of childhood cancer from fetal irradiation", Br J Radiol, 70, pp.130~139 (1997)[DOI]
- Potter EL, "A historical view: diethylstilbestrol use during pregnancy: a 30-year historical perspective", Pediatr Pathol, 11, pp.781~789 (1991)[DOI]
- Bruisma F, "Incidence of cancer in children born after in-vitro fertilization", Hum Reprod, 15, pp.604~607 (2000)[DOI]
- Buckley JD, "The aetiology of cancer in the very young", Br J Cancer Suppl, 18, pp.S8~S12 (1992)
- Schuz J, "Association of childhood cancer with factors related to pregnancy and birth", Int J Epidemiol, 28, pp.631~639 (1999)[DOI]
- Altmann AE, "Associations between congenital malformations and childhood cancer: a registerbased case-control study", Br J Cancer, 78, pp.1244~1249 (1998)[DOI]
- Moore SW, "Neonatal tumours", Pediatr Surg Int, 29, pp.1217~1229 (2013)[DOI]
- Isaacs H, Jr., "Tumors of the fetus and newborn", Major Probl Pathol, 38, pp.224~297 (1997)
- Tongsong T, "Prenatal sonographic features of sacrococcygeal teratoma", Int J Gynaecol Obstet, 67, pp.95~101 (1999)[DOI]
- Woodward PJ, "From the archives of the AFIP: a comprehensive review of fetal tumors with pathologic correlation", Radiographics, 25, pp.215~242 (2005)[DOI]
- Dreyfus M, "Prenatal diagnosis of hepatic hemangioma", Fetal Diagn Ther, 11, pp.57~60 (1996)[DOI]
- Chuileannain FN, "Ultrasonographic appearances of fetal hepatic hemangioma", J Ultrasound Med, 18, pp.379~381 (1999)[DOI]
- Fishman SJ, "Hemangiomas and vascular malformations of infancy and childhood", Pediatr Clin North Am, 40, pp.1177~1200 (1993)[DOI]
- Bader JL, "US cancer incidence and mortality in the first year of life", Am J Dis Child, 133, pp.157~159 (1979)
- Acharya S, "Prenatally diagnosed neuroblastoma", Cancer, 80, pp.304~310 (1997)[DOI]
- Lonergan GJ, "Neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: radiologic-pathologic correlation", Radiographics, 22, pp.911~934 (2002)[DOI]
- Houlihan C, "Prenatal diagnosis of neuroblastoma with sonography and magnetic resonance imaging", Ultrasound Med, 23, pp.547~550 (2004)[DOI]
- Granata C, "Features and outcome of neuroblastoma detected before birth", J Pediatr Surg, 35, pp.88~91 (2000)[DOI]
- Batcup G, "Cancer in the very young child--pitfalls and problems for the pathologist", Br J Cancer Suppl, 18, pp.S5~S7 (1992)
- Moore SW, "The outcome of solid tumours occurring in the neonatal period", Pediatr Surg Int, 10, pp.366~370 (1995)
- Rao S, "Neonatal tumours: a single-centre experience", Pediatr Surg Int, 18, pp.306~309 (2002)[DOI]
- Kearns GL, "Developmental pharmacology--drug disposition, action, and therapy in infants and children", N Engl J Med, 349, pp.1157~1167 (2003)[DOI]