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Analysis of the Influencing Factors of 17-Hydroxyprogesterone Level and the Correlation between 17-Hydroxyprogesterone Level and the Clinical Parameters Related to Adrenal Cortical Function in Very-Low-Birth-Weight Infants

Mi Jin Lee|Chang Dae Kum|Jang Hoon Lee|Moon Sung Park|O Kyu Noh|Young Bae Sohn
대한신생아학회 (THE KOREAN SOCIETY OF NEONATOLOGY)|2019.02|Neonatal medicine|제26권 제1호|pp. 41-47|DOI https://doi.org/10.5385/nm.2019.26.1.41

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키워드

congenitalInfantprematureNeonatal screeningAdrenal insufficiencyAdrenal hyperplasia17-Alpha-hydroxyprogesterone

초록

Purpose: 17-Hydroxyprogesterone (17-OHP) screening results are difficult to interpret owing to the many influencing factors, and confirming the test results takes time. In this study, we examined the factors that affected the 17-OHP level in premature infants. We also evaluated the correlation between 17-OHP level and the clinical parameters related to adrenal cortical function. Methods: From January 2012 to April 2017, 358 very-low-birth-weight infants (VLBWI) born with birth weights of <1,500 g were included in the study. Their 17-OHP levels were measured in the neonatal screening test after birth and analyzed by considering various factors that may have influenced the values. Results: The 17-OHP levels negatively correlated with gestational age and birth weight. The values of the parameters that affected the 17-OHP levels were significantly higher in the infants with respiratory distress syndrome (RDS). In relation to the clinical parameters, blood pressure measured within 24 hours, 72 hours, and 1 week after birth negatively correlated with the 17-OHP level. Serum sodium and 17-OHP levels 24 hours after birth were found to be positively correlated. Urine outputs in 1 and 3 days after birth showed significant positive correlations with the 17-OHP level. Conclusion: The 17-OHP levels of the VLBWIs were higher when gestational age and birth weight were lower, and were influenced by RDS in the VLBWI. In addition, hypotension and urine output values may be useful in the neonatal intensive care unit as a predictor of early adrenal insufficiency.

Abstract

Purpose: 17-Hydroxyprogesterone (17-OHP) screening results are difficult to interpret owing to the many influencing factors, and confirming the test results takes time. In this study, we examined the factors that affected the 17-OHP level in premature infants. We also evaluated the correlation between 17-OHP level and the clinical parameters related to adrenal cortical function. Methods: From January 2012 to April 2017, 358 very-low-birth-weight infants (VLBWI) born with birth weights of <1,500 g were included in the study. Their 17-OHP levels were measured in the neonatal screening test after birth and analyzed by considering various factors that may have influenced the values. Results: The 17-OHP levels negatively correlated with gestational age and birth weight. The values of the parameters that affected the 17-OHP levels were significantly higher in the infants with respiratory distress syndrome (RDS). In relation to the clinical parameters, blood pressure measured within 24 hours, 72 hours, and 1 week after birth negatively correlated with the 17-OHP level. Serum sodium and 17-OHP levels 24 hours after birth were found to be positively correlated. Urine outputs in 1 and 3 days after birth showed significant positive correlations with the 17-OHP level. Conclusion: The 17-OHP levels of the VLBWIs were higher when gestational age and birth weight were lower, and were influenced by RDS in the VLBWI. In addition, hypotension and urine output values may be useful in the neonatal intensive care unit as a predictor of early adrenal insufficiency.

참고문헌 (38)

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관련 논문AI추천

Adrenocortical Function in Preterm InfantsHye Rim Chung대한신생아학회 · Neonatal medicine2015 · 제22권 제3호Dried Blood Spot Multiplexed Steroid Profiling Using Liquid Chromatography Tandem Mass Spectrometry in Korean Neonates박형두, 송정한, 오현주, 이경훈, 이수연, 최리화대한진단검사의학회 · Annals of Laboratory Medicine2019 · 제39권 제3호testo미숙아에서의 17- α-hydroxy progesterone 값에 대한 연구김기수, 김애란, 이병섭, 최용성대한신생아학회 · Neonatal medicine2012 · 제19권 제2호조산아에서 발생하는 부신기능부전과 연관된 저혈압의 임상상김병일, 김이경, 김한석, 손진아, 이은희, 이주영, 이진아, 이현주, 정혜림, 최은진, 최중환, 최창원대한신생아학회 · Neonatal medicine2011 · 제18권 제1호재태주령 32주 이하 미숙아에서 생후 1주 이후 후기 저혈압 및 부신 기능부전과의 관계김병일, 김이경, 김한석, 이진아, 최중환, 최창원대한신생아학회 · Neonatal medicine2011 · 제18권 제2호Dried Blood Spot Testing for Seven Steroids Using Liquid Chromatography-Tandem Mass Spectrometry With Reference Interval Determination in the Korean Population김보람, 김종원, 박원순, 박형두, 이미나, 이수연, 장윤실대한진단검사의학회 · Annals of Laboratory Medicine2015 · 제35권 제6호

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