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혈중 아연 농도가 정상인 모유수유를 한 미숙아에서 보인 장병성 선단 피부염 1례

A Case of Acrodermatitis Enteropathica with Normal Serum Zinc Level in a Breastfed Preterm Infant

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초록

Acrodermatitis enteropathica due to zinc deficiency is characterized by periorificial dermatitis, alopecia, and intractable diarrhea. Here we report a case of transient acrodermatitis enteropathica in a 2-month-old preterm infant, whose skin is erythematous,scaly, eczematous, with an eruption starting from the periorificial area. While her serum zinc level was normal at 118.2 ug/dL,the serum alkaline phosphatase level was low at 48 IU/L and this level get increased concordant with clinical improvement after zinc supplementation. Hence, this case shows that the diagnosis of zinc deficiency can be aided with a low level of serum alkaline phoaphatase although serum zinc level is normal.

Abstract

Acrodermatitis enteropathica due to zinc deficiency is characterized by periorificial dermatitis, alopecia, and intractable diarrhea. Here we report a case of transient acrodermatitis enteropathica in a 2-month-old preterm infant, whose skin is erythematous,scaly, eczematous, with an eruption starting from the periorificial area. While her serum zinc level was normal at 118.2 ug/dL,the serum alkaline phosphatase level was low at 48 IU/L and this level get increased concordant with clinical improvement after zinc supplementation. Hence, this case shows that the diagnosis of zinc deficiency can be aided with a low level of serum alkaline phoaphatase although serum zinc level is normal.

참고문헌 (14)

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  9. Pi SW, "Manual of Neonatal Care. 2nd ed", pp.114~ (2008), Seoul: The Korean Socitey of Neonatology
  10. Krebs NF, "Zinc and breastfed infants: if and when is there a risk of deficiency", Adv Exp Med Biol, 503, pp.69~75 (2002)
  11. Mandato F, "A case of transient zinc deficiency in a breast-fed preterm infant successfully treated with oral zinc supplementation: review of zinc metabolism and related diseases", G Ital Dermatol Venereol, 144, pp.729~734 (2009)
  12. Kienast A, "Zinc-deficiency dermatitis in breast-fed infants", Eur J Pediatr, 166, pp.189~194 (2007)
  13. 오경일, "A case of acquired acrodermatitis enteropathica with a normal serum zinc level but a low level in the hair", Korean Journal of Pediatrics, 50(2), pp.209~212 (2007), 대한소아과학회
  14. Song JK, "A case of transient symptomatic zinc deficiency", J Korean Soc Neonatol, 5, pp.100~103 (1998)

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