단장증후군 초미숙아에서 Probiotics 투약 후 동일 균주에 의한 패혈증 1례
A Case of Lactobacillus Bacteremia during Probiotic Supplementation in a Very Preterm Infant with Short Bowel Syndrome
1
조회
0
다운로드
2
인용
0
참고문헌
키워드
초록
Probiotics are living micro-organisms that beneficially affect the composition of the host intestinal microflora. In very preterm infants, probiotics reportedly help reduce necrotizing enterocolitis (NEC), invasive fugal colonization and sepsis, and enable the establishment of complete enteral feeding at an earlier stage. However, emerging evidence has indicated the risk of potential side effects of probiotic use, such as gut organism translocation, including probiotic organisms, in infants that are more pre- mature. In the present report, we describe a case of Lactobacillus bacteremia in a very preterm infant with short bowel syndrome. Lactobacillus sepsis developed during the therapeutic use of this organism for diarrhea and diarrhea-related malab- sorption. The organism isolated from the blood sample was found to be of the same strain as that administered, by using molecular techniques. The findings of the present case suggest that probiotics should be carefully used, particularly in very preterm infants with altered intestinal permeability such as short bowel syndrome.
Abstract
Probiotics are living micro-organisms that beneficially affect the composition of the host intestinal microflora. In very preterm infants, probiotics reportedly help reduce necrotizing enterocolitis (NEC), invasive fugal colonization and sepsis, and enable the establishment of complete enteral feeding at an earlier stage. However, emerging evidence has indicated the risk of potential side effects of probiotic use, such as gut organism translocation, including probiotic organisms, in infants that are more pre- mature. In the present report, we describe a case of Lactobacillus bacteremia in a very preterm infant with short bowel syndrome. Lactobacillus sepsis developed during the therapeutic use of this organism for diarrhea and diarrhea-related malab- sorption. The organism isolated from the blood sample was found to be of the same strain as that administered, by using molecular techniques. The findings of the present case suggest that probiotics should be carefully used, particularly in very preterm infants with altered intestinal permeability such as short bowel syndrome.
참고문헌 (20)
- Report of a joint FAO, "WHO expert consultation on evaluation of health and nutritional properties of probiotics in food including powder milk with live lactic acid bacteria", Food and Agriculture Organization of the United Nations, 2001
- Hartel C, "Prophylactic use of Lactobacillus acidophilus", Bifidobacterium infantis probiotics and outcome in very low birth weight infants, 2014, pp.165, 285~289.e1
- AlFaleh K, "Probiotics for prevention of necrotizing enterocolitis in preterm infants", Evid Based Child Health, 9, pp.584~671 (2014)
- Rojas MA, "Prophylactic probiotics to prevent death and nosocomial infection in preterm infants", Pediatrics, 130, pp.e1113~1120 (2012)
- Thygesen JB, "Saccharomyces boulardii fungemia caused by treatment with a probioticum", BMJ Case Rep (2012), BMJ[DOI]
- De Groote MA, "Lactobacillus rhamnosus GG bacteremia associated with probiotic use in a child with short gut syndrome", Pediatr Infect Dis J, 24, pp.278~280 (2005)
- Kunz AN, "Two cases of Lactobacillus bacteremia during probiotic treatment of short gut syndrome", J Pediatr Gastroenterol Nutr, 38, pp.457~458 (2004)
- O'Keefe SJ, "Short bowel syndrome and intestinal failure: consensus definitions and overview", Clin Gastroenterol Hepatol, 4, pp.6~10 (2006)
- Touloukian RJ, "Normal intestinal length in preterm infants", J Pediatr Surg, 18, pp.720~723 (1983)
- Wales PW, "Neonatal short bowel syndrome: a cohort study", J Pediatr Surg, 40, pp.755~762 (2005)
- Floch MH, "The effect of probiotics on host metabolism: the microbiota and fermentation", J Clin Gastroenterol, 44(Suppl 1), pp.S19~21 (2010)
- Tappenden KA, "Systemic short-chain fatty acids rapidly alter gastrointestinal structure, function, and expression of early response genes", Dig Dis Sci, 43, pp.1526~1536 (1998)
- Madsen K, "Probiotic bacteria enhance murine and human intestinal epithelial barrier function", Gastroenterology, 121, pp.580~591 (2001)
- Mangell P, "Lactobacillus plantarum 299v inhibits Escherichia coliinduced intestinal permeability", Dig Dis Sci, 47, pp.511~516 (2002)
- Lievin V, "Bifidobacterium strains from resident infant human gastrointestinal microflora exert antimicrobial activity", Gut, 47, pp.646~652 (2000)
- Vanderhoof JA, "Treatment strategies for small bowel bacterial overgrowth in short bowel syndrome", J Pediatr Gastroenterol Nutr, 27, pp.155~160 (1998)
- Kanamori Y, "Combination therapy with Bifidobacterium breve, Lactobacillus casei, and galactooligosaccharides dramatically improved the intestinal function in a girl with short bowel syndrome: a novel synbiotics therapy for intestinal failure", Dig Dis Sci, 46, pp.2010~2016 (2001)
- Uchida K, "Immunonutritional effects during synbiotics therapy in pediatric patients with short bowel syndrome", Pediatr Surg Int, 23, pp.243~248 (2007)
- Ku WH, "Probiotics provoked D-lactic acidosis in short bowel syndrome: case report and literature review", HK J Paediatr, 11, pp.246~254 (2006)
- Zbinden A, "Case series of Bifidobacterium longum bateremia in three preterm infants on probiotic therapy", Neonatology, 107, pp.56~59 (2015)