Relation Between Absoute Nucelated Red Blood Cell Count at Birth and Retinopathy of Prematurity
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Purpose: The aim of this study is to prove the association between potential fetal hypoxia and retinopathy of prematurity (ROP) development and absolute nucleated red blood cell (aNRBC) is used to evaluate it in premature infants without any hypoxic or ischemic history. Methods: Medical records of 43 premature infants with ROP who were admitted to the neonatal intensive care unit at Wonkwang University Hospital from January 2004 to December 2014 were analyzed retrospectively. We excluded 15 infants who had a confounding medical condition that could have increased the aNRBC count. Finally, 28 premature infants affected by ROP were enrolled and compared with 28 pair-matched controls. The aNRBC counts at birth in these infants were compared. Statistical analysis was performed with a paired t-test for continuous data, and a Fisher’s exact test for categorical data. P<0.05 was considered significant. Results: There were no significant differences in perinatal characteristics such as gestational age (GA), birth weight (BWt), Apgar scores, premature rupture of membrane (>24 hours), prenatal betamethasone, surfactant or respiratory distress syndrome between the ROP and the control infants. In addition, neither group differed in major morbidities such as patent ductus arteriosus, periventricular leukomalacia, intraventricular hemorrhage (≥Grade 2), or bronchopulmonary dysplasia. Regardless of the severity of ROP, the aNRBC counts at birth in premature infants with ROP were not higher than in the control infants. Conclusion: The aNRBC counts at birth may not be related directly to the development of ROP.
Abstract
Purpose: The aim of this study is to prove the association between potential fetal hypoxia and retinopathy of prematurity (ROP) development and absolute nucleated red blood cell (aNRBC) is used to evaluate it in premature infants without any hypoxic or ischemic history. Methods: Medical records of 43 premature infants with ROP who were admitted to the neonatal intensive care unit at Wonkwang University Hospital from January 2004 to December 2014 were analyzed retrospectively. We excluded 15 infants who had a confounding medical condition that could have increased the aNRBC count. Finally, 28 premature infants affected by ROP were enrolled and compared with 28 pair-matched controls. The aNRBC counts at birth in these infants were compared. Statistical analysis was performed with a paired t-test for continuous data, and a Fisher’s exact test for categorical data. P<0.05 was considered significant. Results: There were no significant differences in perinatal characteristics such as gestational age (GA), birth weight (BWt), Apgar scores, premature rupture of membrane (>24 hours), prenatal betamethasone, surfactant or respiratory distress syndrome between the ROP and the control infants. In addition, neither group differed in major morbidities such as patent ductus arteriosus, periventricular leukomalacia, intraventricular hemorrhage (≥Grade 2), or bronchopulmonary dysplasia. Regardless of the severity of ROP, the aNRBC counts at birth in premature infants with ROP were not higher than in the control infants. Conclusion: The aNRBC counts at birth may not be related directly to the development of ROP.
참고문헌 (33)
- Phelps DL, "Fanaroff and Martin’s neonatal-perinatal medicine", pp.1764~1769 (2011), Elsevier Mosby
- Chiang MF, "Incidence of retinopathy of prematurity from 1996 to 2000. Analysis of a comprehensive New York State patient database", Ophthalmology, 111, pp.1317~1325 (2004)
- Ra EY, "Incidence, timing of screening examinations and perinatal risk factors for retinopathy of prematurity in very low birth weight infants", Korean J Perinatol, 13, pp.390~398 (2002)
- Smith LE, "Pathogenesis of retinopathy of prematurity", Semin Neonatol, 8, pp.469~473 (2003)
- Chen J, "Retinopathy of prematurity", Angiogenesis, 10, pp.133~140 (2007)
- Mccolm JR, "Retinopathy of prematurity: causation", Semin Neonatol, 6, pp.453~460 (2001)
- Hellstrm A, "Retinopathy of prematurity", Lancet, 382, pp.1445~1457 (2013)
- Bardin C, "Outcome of small-forgestational age and appropriate-for-gestational age infants born before 27 weeks of gestation", Pediatrics, 100, pp.e4~ (1997)
- Arroe M, "Retinopathy of prematurity in a Danish neonatal intensive care unit, 1985-1991", Acta Ophthalmol Suppl, 210, pp.37~40 (1993)
- Teramo KA, "Amniotic fluid erythropoietin correlates with umbilical plasma erythropoietin in normal and abnormal pregnancy", Obstet Gynecol, 69, pp.710~716 (1987)
- Mamopoulos M, "Erythropoitin umbilical serum levels during labor in women with preeclampsia, diabetes, and preterm labor", Am J Perinatol, 11, pp.427~429 (1994)
- Salvesen DR, "Fetal plasma erythropoietin in pregnancy complicated by maternal diabetes mellitus", Am J Obstet Gynecol, 168, pp.88~94 (1993)
- Varvarigou A, "Increased levels and positive correlation between erythropoietin and hemoglobin concentration s in newborn children of mothers who smokers", J Pediatr, 124, pp.480~482 (1994)
- Voutilainen PE, "Amniotic fluid erythropoietin predicts fetal distress in Rhimmunized pregnancies", Am J Obstet Gynecol, 160, pp.429~434 (1989)
- Hermansen MC, "Nucleated red blood cells in the fetus and newborn", Arch Dis Child Fetal Neonatal Ed, 84, pp.211~215 (2001)
- Sills RH, "The significance of nucleated red blood cells in the peripheral blood of children", Am J Pediatr Hematol Oncol, 5, pp.173~177 (1983)
- Lubetzky R, "Nucleated red blood cells in preterm infants with retinopathy of prematurity", Pediatrics, 116, pp.e619~e622 (2005)
- Minior VK, "Nucleated red blood cells in growth-restricted fetuses: associations with short-term neonatal outcome", Fetal Diagn Ther, 15, pp.165~169 (2000)
- Lubchenco LO, "Intrauterine growth as estimated from live-born birth weight data at 24 to 42 weeks gestation", Pediatrics, 32, pp.793~799 (1963)
- Sinha HB, "Cord blood haemoglobin (including foetal haemoglobin), and nucleated red cells in normal and toxaemic pregnancies", Indian Pediatr, 9, pp.540~543 (1972)
- Green DW, "Nucleated erythrocytes in healthy infants and in infants of diabetic mothers", J Pediatr, 166, pp.129~131 (1990)
- Korst LM, "Nucleated red blood cells: an update on the marker for fetal asphyxia", Am J Obstet Gynecol, 175, pp.843~846 (1996)
- Tita AT, "Diagnosis and management of clinical chorioamnionitis", Clin Perinatol, 37, pp.339~354 (2010)
- Section on Ophthalmology, "Screening examination of premature infants for retinopathy of prematurity", Pediatrics, 117, pp.572~576 (2006)
- Kinsella JP, "Bronchopulmonary dysplasia", Lancet, 367, pp.1421~1431 (2006)
- Naeye RL, "Determinig the time before birth when ischemia and hypoxemia initiated cerebral palsy", Obstet Gynecol, 86, pp.713~719 (1995)
- Green DW, "Nucleated erythrocytes and intraventricular hemorrhage in preterm neonates", Pediatrics, 96, pp.475~478 (1995)
- Oski FA, "Normal blood values in the newborn period. Hematologic problems in the newborn", pp.1~30 (1972), WB Saunders
- Buonocore G, "Nucleated red blood cell countat birth as an index of perinatal brain damage", Am J Obstet Gynecol, 181, pp.1500~1505 (1999)
- Vatansever U, "Nucleated blood cell counts and erythropoietin levels in high-risk neonates", Pediatr Int, 44, pp.590~595 (2002)
- Niranjan HS, "Role of hematological parameters in predicting retinopathy of prematurity (ROP) in preterm neonates", Indian J Pediatr, 80, pp.726~730 (2013)
- Gotru S, "The absolute nucleated red blood cell (aNRBC) count at birth is not an indicator for retinopathy of prematurity (ROP)", J Perinatol, 33, pp.21~24 (2013)
- Christensen RD, "Reference ranges for blood concentrations of nucleated red blood cells in neonates", Neonatology, 99, pp.289~294 (2011)