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단일 신생아집중치료실에서 완전 모유 수유 적용 이후 괴사성 장염의 발생 빈도 감소

Decreased Incidence of Necrotizing Enterocolitis after Introduction of Exclusive Breast Milk Feeding in a Single Neonatal Intensive Care Center

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Purpose: To evaluate the effects of exclusive breast milk feeding (BMF) on the incidence of necrotizing enterocolitis (NEC) in preterm infants. Methods: All newborn infants, born at <32 weeks of gestation and weighing <1,500 g, admitted to the neonatal intensive care center at Seoul National University Bundang Hospital during the study period, were included. The study was divided into period I: pre-exclusive BMF (January 2010–March 2014) and period II: exclusive BMF (April 2014–December 2016). Results: A total of 374 infants were enrolled in this study, with 174 in period I and 174 in period II. The incidence of NEC was 11.5% in period I and 3.4% in period II. As the mean gestational age and birth weight were significantly greater in infants in period II, the difference in the incidence of NEC between the two periods was adjusted by gestational age. After adjustment, the incidence of NEC in period II was significantly lower than in period I (P=0.024). Conclusion: Exclusive BMF significantly reduced the incidence of NEC in a single neonatal intensive care center.

Abstract

Purpose: To evaluate the effects of exclusive breast milk feeding (BMF) on the incidence of necrotizing enterocolitis (NEC) in preterm infants. Methods: All newborn infants, born at <32 weeks of gestation and weighing <1,500 g, admitted to the neonatal intensive care center at Seoul National University Bundang Hospital during the study period, were included. The study was divided into period I: pre-exclusive BMF (January 2010–March 2014) and period II: exclusive BMF (April 2014–December 2016). Results: A total of 374 infants were enrolled in this study, with 174 in period I and 174 in period II. The incidence of NEC was 11.5% in period I and 3.4% in period II. As the mean gestational age and birth weight were significantly greater in infants in period II, the difference in the incidence of NEC between the two periods was adjusted by gestational age. After adjustment, the incidence of NEC in period II was significantly lower than in period I (P=0.024). Conclusion: Exclusive BMF significantly reduced the incidence of NEC in a single neonatal intensive care center.

참고문헌 (40)

  1. Neu J, "Necrotizing enterocolitis", N Engl J Med, 364, pp.255~264 (2011)
  2. Stoll BJ, "Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network", Pediatrics, 126, pp.443~456 (2010)
  3. Horbar JD, "Mortality and neonatal morbidity among infants 501to 1500 grams from 2000 to 2009", Pediatrics, 129, pp.1019~1026 (2012)
  4. Clark RH, "Characteristics of patients who die of necrotizing enterocolitis", J Perinatol, 32, pp.199~204 (2012)
  5. Hintz SR, "Neurodevelopmental and growth outcomes of extremely low birth weight infants after necrotizing enterocolitis", Pediatrics, 115, pp.696~703 (2005)
  6. Rees CM, "Neurodevelopmental outcomes of neonates with medically and surgically treated necrotizing enterocolitis", Arch Dis Child Fetal Neonatal Ed, 92, pp.F193~F198 (2007)
  7. Shah DK, "Adverse neurodevelopment in preterm infants with postnatal sepsis or necrotizing enterocolitis is mediated by white matter abnormalities on magnetic resonance imaging at term", J Pediatr, 153, pp.170~175 (2008)
  8. "Mult Scler Relat Disord", 2012, 108~
  9. Claud EC, "Bacterial colonization, probiotics, and necrotizing enterocolitis", J Clin Gastroenterol, 42(Suppl 2), pp.S46~S52 (2008)
  10. Blau J, "Transfusion-related acute gut injury: necrotizing enterocolitis in very low birth weight neonates after packed red blood cell transfusion", J Pediatr, 158, pp.403~409 (2011)
  11. Lambert DK, "Fulminant necrotizing enterocolitis in a multihospital healthcare system", J Perinatol, 32, pp.194~198 (2012)
  12. Stritzke AI, "Transfusionassociated necrotising enterocolitis in neonates", Arch Dis Child Fetal Neonatal Ed, 98, pp.F10~F14 (2013)
  13. Sankaran K, "Variations in incidence of necrotizing enterocolitis in Canadian neonatal intensive care units", J Pediatr Gastroenterol Nutr, 39, pp.366~372 (2004)
  14. Dollberg S, "Patent ductus arteriosus, indomethacin and necrotizing enterocolitis in very low birth weight infants: a population-based study", J Pediatr Gastroenterol Nutr, 40, pp.184~188 (2005)
  15. Moss RL, "Clinical parameters do not adequately predict outcome in necrotizing enterocolitis: a multi-institutional study", J Perinatol, 28, pp.665~674 (2008)
  16. Meinzen-Derr J, "Role of human milk in extremely low birth weight infants' risk of necrotizing enterocolitis or death", J Perinatol, 29, pp.57~62 (2009)
  17. Sisk PM, "Early human milk feeding is associated with a lower risk of necrotizing enterocolitis in very low birth weight infants", J Perinatol, 27, pp.428~433 (2007)
  18. Johnson TJ, "Economic benefits and costs of human milk feedings: a strategy to reduce the risk of prematurity-related morbidities in very-lowbirth-weight infants", Adv Nutr, 5, pp.207~212 (2014)
  19. Alshaikh B, "Effect of a quality improvement project to use exclusive mother's own milk on rate of necrotizing enterocolitis in preterm infants", Breastfeed Med, 10, pp.355~361 (2015)
  20. Talavera MM, "Quality improvement initiative to reduce the necrotizing enterocolitis rate in premature infants", Pediatrics, 137 (2016)[DOI]
  21. Youn YA, "Necrotizing enterocolitis among very-low-birth weight infants in Korea", J Korean Med Sci, 30(Suppl 1), pp.S75~S80 (2015)[DOI]
  22. Isayama T, "Comparison of mortality and morbidity of very low birth weight infants between Canada and Japan", Pediatrics, 130, pp.e957~e965 (2012)
  23. 장혜림, "The Experience of Human Milk Banking for 8 Years: Korean Perspective", Journal of Korean Medical Science, 31(11), pp.1775~1783 (2016), 대한의학회
  24. Bell MJ, "Perforation of the gastrointestinal tract and peritonitis in the neonate", Surg Gynecol Obstet, 160, pp.20~26 (1985)
  25. Papile LA, "Incidence and evolution of subependymal and intraventricular hemorrhage:a study of infants with birth weights less than 1,500 gm", J Pediatr, 92, pp.529~534 (1978)
  26. Underwood MA, "Human milk for the premature infant", Pediatr Clin North Am, 60, pp.189~207 (2013)
  27. Ewaschuk JB, "Effect of pasteurization on immune components of milk: implications for feeding preterm infants", Appl Physiol Nutr Metab, 36, pp.175~182 (2011)
  28. Henderson G, "Formula milk versus maternal breast milk for feeding preterm or low birth weight infants", Cochrane Database Syst Rev, pp.CD002972~ (2007)[DOI]
  29. Morgan J, "Early trophic feeding versus enteral fasting for very preterm or very low birth weight infants", Cochrane Database Syst Rev, pp.CD000504~ (2013)[DOI]
  30. Corpeleijn WE, "Human milk banking-facts and issues to resolve", Nutrients, 2, pp.762~769 (2010)
  31. Mussi-Pinhata MM, "Placental transfer of naturally acquired, maternal cytomegalovirus antibodies in term and preterm neonates", J Med Virol, 69, pp.232~239 (2003)
  32. Dworsky M, "Cytomegalovirus infection of breast milk and transmission in infancy", Pediatrics, 72, pp.295~299 (1983)
  33. Vochem M, "Transmission of cytomegalovirus to preterm infants through breast milk", Pediatr Infect Dis J, 17, pp.53~58 (1998)
  34. Hamprecht K, "Epidemiology of transmission of cytomegalovirus from mother to preterm infant by breastfeeding", Lancet, 357, pp.513~518 (2001)
  35. Maschmann J, "Cytomegalovirus infection of extremely low-birth weight infants via breast milk", Clin Infect Dis, 33, pp.1998~2003 (2001)
  36. Curtis N, "Cytomegalovirus remains viable in naturally infected breast milk despite being frozen for 10 days", Arch Dis Child Fetal Neonatal Ed, 90, pp.F529~F530 (2005)
  37. Friis H, "Rate of inactivation of cytomegalovirus in raw banked milk during storage at -20 degrees C and pasteurisation", Br Med J (Clin Res Ed), 285, pp.1604~1605 (1982)
  38. Dworsky M, "Persistence of cytomegalovirus in human milk after storage", J Pediatr, 101, pp.440~443 (1982)
  39. Braga TD, "Efficacy of Bifidobacterium breve and Lactobacillus casei oral supplementation on necrotizing enterocolitis in very-low-birth-weight preterm infants: a double-blind, randomized, controlled trial", Am J Clin Nutr, 93, pp.81~86 (2011)
  40. AlFaleh K, "Probiotics for prevention of necrotizing enterocolitis in preterm infants", Evid Based Child Health, 9, pp.584~671 (2014)

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