Role of Cortico-ponto-cerebellar Tract from Supplementary Motor Area in Ataxic Hemiparesis of Supratentorial Stroke Patients
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Cortical lesions of the supplementary motor area (SMA) are important in balance control and postural recovery in stroke patients, while the role of subcortical lesions of the SMA has not been studied. This study aimed to investigate the subcortical projections of the SMA and its relationship with ataxia in supratentorial stroke patients. Thirty-three patients with hemiparesis were divided into 3 groups (severe ataxia, n = 9; mild to moderate ataxia, n = 13; no ataxia, n = 11). Ataxia severity was assessed using the Scale for Ataxia Rating Assessment. Diffusion tensor imaging analysis used the fractional anisotropy (FA) values and tract volume as parameters of white matter tract degeneration. The FA values of regions related to ataxia were analyzed, that is the SMA, posterior limb of the internal capsule, basal ganglia, superior cerebellar peduncle, middle cerebellar peduncle, inferior cerebellar peduncle, and cerebellum. Tract volumes of the corticostriatal tract and cortico-ponto-cerebellar (CPC) tract originating from the SMA were evaluated. There were significant differences among the 3 groups in FA values of the subcortical regions of the CPC tract. Furthermore, the volume of the CPC tract originating from the SMA showed significant negative correlation with ataxia severity. There was no correlation between ataxia and corticostriatal tract volume. Therefore, we found that subcortical lesions of the CPC tract originating from the SMA could contribute to ataxia severity in stroke patients with ataxic hemiparesis
Abstract
Cortical lesions of the supplementary motor area (SMA) are important in balance control and postural recovery in stroke patients, while the role of subcortical lesions of the SMA has not been studied. This study aimed to investigate the subcortical projections of the SMA and its relationship with ataxia in supratentorial stroke patients. Thirty-three patients with hemiparesis were divided into 3 groups (severe ataxia, n = 9; mild to moderate ataxia, n = 13; no ataxia, n = 11). Ataxia severity was assessed using the Scale for Ataxia Rating Assessment. Diffusion tensor imaging analysis used the fractional anisotropy (FA) values and tract volume as parameters of white matter tract degeneration. The FA values of regions related to ataxia were analyzed, that is the SMA, posterior limb of the internal capsule, basal ganglia, superior cerebellar peduncle, middle cerebellar peduncle, inferior cerebellar peduncle, and cerebellum. Tract volumes of the corticostriatal tract and cortico-ponto-cerebellar (CPC) tract originating from the SMA were evaluated. There were significant differences among the 3 groups in FA values of the subcortical regions of the CPC tract. Furthermore, the volume of the CPC tract originating from the SMA showed significant negative correlation with ataxia severity. There was no correlation between ataxia and corticostriatal tract volume. Therefore, we found that subcortical lesions of the CPC tract originating from the SMA could contribute to ataxia severity in stroke patients with ataxic hemiparesis
참고문헌 (38)
- Fujimoto H, "Cortical changes underlying balance recovery in patients with hemiplegic stroke", Neuroimage, 85, pp.547~554 (2014)
- Marlin A, "Localizing evoked cortical activity associated with balance reactions: does the anterior cingulate play a role?", J Neurophysiol, 111, pp.2634~2643 (2014)
- Toyokura M, "Activation of pre-supplementary motor area(SMA)and SMA proper during unimanual and bimanual complex sequences : an analysis using functional magnetic resonance imaging", J Neuroimaging, 12, pp.172~178 (2002)
- Hummel FC, "Non-invasive brain stimulation: a new strategy to improve neurorehabilitation after stroke?", Lancet Neurol, 5, pp.708~712 (2006)
- Mihara M, "Neurofeedback using real-time near-infrared spectroscopy enhances motor imagery related cortical activation", PLoS One, 7, pp.e32234~ (2012)
- Sitaram R, "Acquired control of ventral premotor cortex activity by feedback training : an exploratory real-time FMRI and TMS study", Neurorehabil Neural Repair, 26, pp.256~265 (2012)
- Tzvi E, "Cerebellar degeneration affects cortico-cortical connectivity in motor learning networks", Neuroimage Clin, 16, pp.66~78 (2017)
- Schmahmann JD, "Cerebral white matter : neuroanatomy, clinical neurology, and neurobehavioral correlates", Ann N Y Acad Sci, 1142, pp.266~309 (2008)
- Vergani F, "White matter connections of the supplementary motor area in humans", J Neurol Neurosurg Psychiatry, 85, pp.1377~1385 (2014)
- Bozkurt B, "Fiber connections of the supplementary motor area revisited: methodology of fiber dissection, DTI, and three dimensional documentation", J Vis Exp, pp.e55681~ (2017)
- Akkal D, "Supplementary motor area and presupplementary motor area : targets of basal ganglia and cerebellar output", J Neurosci, 27, pp.10659~10673 (2007)
- Manto M, "Handbook of the cerebellum and cerebellar disorders" (2013), Springer
- Gerraty RP, "Examining the lacunar hypothesis with diffusion and perfusion magnetic resonance imaging", Stroke, 33, pp.2019~2024 (2002)
- Arboix A, "Clinical study of 23 patients with ataxic hemiparesis", Med Clin(Barc), 122, pp.342~344 (2004)
- 최성원, "Evaluation of Ataxia in Mild Ischemic Stroke Patients Using the Scale for the Assessment and Rating of Ataxia (SARA)", Annals of Rehabilitation Medicine, 42(3), pp.375~383 (2018), 대한재활의학회
- Bamford J, "The natural history of lacunar infarction : the Oxfordshire Community Stroke Project", Stroke, 18, pp.545~551 (1987)
- Sinha KK, "Brain stem infarction : clinical clues to localize them", J Indian Acad Clin Med, 1, pp.213~221 (2000)
- Hiraga A, "Diffusion weighted imaging in ataxic hemiparesis", J Neurol Neurosurg Psychiatry, 78, pp.1260~1262 (2007)
- Schmitz-Hübsch T, "Scale for the assessment and rating of ataxia : development of a new clinical scale", Neurology, 66, pp.1717~1720 (2006)
- Weyer A, "Reliability and validity of the scale for the assessment and rating of ataxia : a study in 64 ataxia patients", Mov Disord, 22, pp.1633~1637 (2007)
- Subramony SH, "SARA--a new clinical scale for the assessment and rating of ataxia", Nat Clin Pract Neurol, 3, pp.136~137 (2007)
- Palesi F, "Contralateral cortico-ponto-cerebellar pathways reconstruction in humans in vivo : implications for reciprocal cerebro-cerebellar structural connectivity in motor and non-motor areas", Sci Rep, 7, pp.12841~ (2017)
- Lehéricy S, "3-D diffusion tensor axonal tracking shows distinct SMA and pre-SMA projections to the human striatum", Cereb Cortex, 14, pp.1302~1309 (2004)
- Kitamura K, "Diffusion tensor imaging of the cortico-ponto-cerebellar pathway in patients with adult-onset ataxic neurodegenerative disease", Neuroradiology, 50, pp.285~292 (2008)
- Jang SH, "Relationship between ataxia and inferior cerebellar peduncle injury in patients with cerebral infarct", Medicine(Baltimore), 99, pp.e19344~ (2020)
- Oh ME, "DTI fiber tractography of cerebro-cerebellar pathways and clinical evaluation of ataxia in childhood posterior fossa tumor survivors", J Neurooncol, 131, pp.267~276 (2017)
- Hong JH, "Cerebellar peduncle injury in patients with ataxia following diffuse axonal injury", Brain Res Bull, 80, pp.30~35 (2009)
- Kamali A, "Diffusion tensor tractography of the human brain cortico-ponto-cerebellar pathways : a quantitative preliminary study", J Magn Reson Imaging, 32, pp.809~817 (2010)
- 김한준, "Changes in Diffusion Metrics of the Red Nucleus in Chronic Stroke Patients With Severe Corticospinal Tract Injury: A Preliminary Study", Annals of Rehabilitation Medicine, 42(3), pp.396~405 (2018), 대한재활의학회
- Kim MS, "Recovery of cerebellar peduncle injury in a patient with a cerebellar tumor : validation by diffusion tensor tractography", Neural Regen Res, 9, pp.1929~1932 (2014)
- Penfield W, "The supplementary motor area of the cerebral cortex; a clinical and experimental study", AMA Arch Neurol Psychiatry, 66, pp.289~317 (1951)
- Jang SH, "Injury of the cortico-ponto-cerebellar tract in a patient with mild traumatic brain injury: a case report", Medicine (Baltimore), 96, pp.e8749~ (2017)
- Keser Z, "Diffusion tensor imaging of the human cerebellar pathways and their interplay with cerebral macrostructure", Front Neuroanat, 9, pp.41~ (2015)
- Mohar M, "Rehabilitation course and specification of dysmetria of a patient with ataxia, dysmetria, and hemiparesis after a stroke in the corona radiata : a case presentation", PM R, 10, pp.974~978 (2018)
- Takakusaki K, "Role of basal ganglia-brainstem systems in the control of postural muscle tone and locomotion", Prog Brain Res, 143, pp.231~237 (2004)
- Tei H, "Capsular infarcts : location, size and etiology of pure motor hemiparesis, sensorimotor stroke and ataxic hemiparesis", Acta Neurol Scand, 88, pp.264~268 (1993)
- Puig J, "Wallerian degeneration in the corticospinal tract evaluated by diffusion tensor imaging correlates with motor deficit 30 days after middle cerebral artery ischemic stroke", AJNR Am J Neuroradiol, 31, pp.1324~1330 (2010)
- Wang C, "Longitudinal changes in white matter following ischemic stroke : a three-year follow-up study", Neurobiol Aging, 27, pp.1827~1833 (2006)