Full-Term Baby with Cerebellar Hemorrhage Referred for Severe Jaundice Occurring within the First 3 Days of Life
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Cerebellar hemorrhage in full-term infants is a rare condition recently recognized in high-risk newborns requiring intensive care with the availability of advanced neuroimaging techniques. Several aspects such as the incidence, pathophysiology, clinical features, and prognosis of cerebellar hemorrhage in full-term infants remain unknown. We present a case of cerebellar hemorrhage with subdural hemorrhage in a patient hospitalized for jaundice after birth without a history of traumatic delivery, such as breech presentation, prolonged labor or forceps delivery. A full-term female infant weighing 3,100 g at birth, with no complications during delivery, developed jaundice within 48 hours of birth and was admitted for intensive phototherapy in the first 3 days of life with a transcutaneous total bilirubin level of 18.1 mg/dL. Magnetic resonance imaging revealed cerebellar brain lesions with a subdural hemorrhage. At the age of 3 months, the infant exhibited leg rigidity and was referred for rehabilitation. The patient showed signs of improvement during treatment and was generally catching up well with her peers at the age of 9 months. Long-term follow-ups are required to evaluate the consequences on cognitive development, behavior, and motor performance subsequently in life.
Abstract
Cerebellar hemorrhage in full-term infants is a rare condition recently recognized in high-risk newborns requiring intensive care with the availability of advanced neuroimaging techniques. Several aspects such as the incidence, pathophysiology, clinical features, and prognosis of cerebellar hemorrhage in full-term infants remain unknown. We present a case of cerebellar hemorrhage with subdural hemorrhage in a patient hospitalized for jaundice after birth without a history of traumatic delivery, such as breech presentation, prolonged labor or forceps delivery. A full-term female infant weighing 3,100 g at birth, with no complications during delivery, developed jaundice within 48 hours of birth and was admitted for intensive phototherapy in the first 3 days of life with a transcutaneous total bilirubin level of 18.1 mg/dL. Magnetic resonance imaging revealed cerebellar brain lesions with a subdural hemorrhage. At the age of 3 months, the infant exhibited leg rigidity and was referred for rehabilitation. The patient showed signs of improvement during treatment and was generally catching up well with her peers at the age of 9 months. Long-term follow-ups are required to evaluate the consequences on cognitive development, behavior, and motor performance subsequently in life.
참고문헌 (19)
- Steggerda SJ, "Cerebellar injury in preterm infants : incidence and findings on US and MR images", Radiology, 252, pp.190~199 (2009)
- Boswinkel V, "The CHOPIn study : a multicenter study on cerebellar hemorrhage and outcome in preterm infants", Cerebellum, 18, pp.989~998 (2019)
- Pierson CR, "Preterm birth and cerebellar neuropathology", Semin Fetal Neonatal Med, 21, pp.305~311 (2016)
- Bulas DI, "Posterior fossa intracranial hemorrhage in infants treated with extracorporeal membrane oxygenation : sonographic findings", AJR Am J Roentgenol, 156, pp.571~575 (1991)
- Limperopoulos C, "Cerebellar injury in term infants : clinical characteristics, magnetic resonance imaging findings, and outcome", Pediatr Neurol, 41, pp.1~8 (2009)
- Steggerda SJ, "Posterior fossa abnormalities in high-risk term infants : comparison of ultrasound and MRI", Eur Radiol, 25, pp.2575~2583 (2015)
- Stolwijk LJ, "Neonatal surgery for noncardiac congenital anomalies : neonates at risk of brain injury", J Pediatr, 182, pp.335~341 (2017)
- Whitby EH, "Frequency and natural history of subdural haemorrhages in babies and relation to obstetric factors", Lancet, 363, pp.846~851 (2004)
- Biran V, "Perinatal cerebellar injury in human and animal models", Neurol Res Int, 2012, pp.858929~ (2012)
- Anderson NB, "Neonatal indirect hyperbilirubinemia", Neoreviews, 21, pp.e749~e760 (2020)
- Singh J, "Neonatal adrenal hemorrhage presenting as prolonged hyperbilirubinemia", J Neonatal Surg, 5, pp.22~ (2016)
- Dennery PA, "Neonatal hyperbilirubinemia", N Engl J Med, 344, pp.581~590 (2001)
- Kim C, "The clinical characteristics and the neurodevelopmental outcomes of the neonates with cerebellar hemorrhage", Neonatal Med, 20, pp.113~120 (2013)
- Berg RM, "Effects of short-term mechanical hyperventilation on cerebral blood flow and dynamic cerebral autoregulation in critically ill patients with sepsis", Scand J Clin Lab Invest, 76, pp.226~233 (2016)
- Merrill JD, "A new pattern of cerebellar hemorrhages in preterm infants", Pediatrics, 102, pp.E62~ (1998)
- Kidokoro H, "Brain injury and altered brain growth in preterm infants : predictors and prognosis", Pediatrics, 134, pp.e444~e453 (2014)
- Ecury-Goossen GM, "The clinical presentation of preterm cerebellar haemorrhage", Eur J Pediatr, 169, pp.1249~1253 (2010)
- Steggerda SJ, "Cranial ultrasonography of the immature cerebellum : role and limitations", Semin Fetal Neonatal Med, 21, pp.295~304 (2016)
- Williamson WD, "Cerebellar hemorrhage in the term neonate : developmental and neurologic outcome", Pediatr Neurol, 1, pp.356~360 (1985)