본문 바로가기
KERD
논문KCI 등재

Application of Standardization for Causal Inference in Observational Studies: A Step-by-step Tutorial for Analysis Using R Software

1

조회

0

다운로드

0

인용

0

참고문헌

키워드

초록

Epidemiological studies typically examine the causal effect of exposure on a health outcome. Standardization is one of the most straightforward methods for estimating causal estimands. However, compared to inverse probability weighting, there is a lack of user-centric explanations for implementing standardization to estimate causal estimands. This paper explains the standardization method using basic R functions only and how it is linked to the R package stdReg, which can be used to implement the same procedure. We provide a step-by-step tutorial for estimating causal risk differences, causal risk ratios, and causal odds ratios based on standardization. We also discuss how to carry out subgroup analysis in detail.

Abstract

Epidemiological studies typically examine the causal effect of exposure on a health outcome. Standardization is one of the most straightforward methods for estimating causal estimands. However, compared to inverse probability weighting, there is a lack of user-centric explanations for implementing standardization to estimate causal estimands. This paper explains the standardization method using basic R functions only and how it is linked to the R package stdReg, which can be used to implement the same procedure. We provide a step-by-step tutorial for estimating causal risk differences, causal risk ratios, and causal odds ratios based on standardization. We also discuss how to carry out subgroup analysis in detail.

참고문헌 (20)

  1. Concato J, "Randomized, controlled trials, observational studies, and the hierarchy of research designs", N Engl J Med, 342(25), pp.1887~1892 (2000)
  2. Altman N, "Association, correlation and causation", Nat Methods, 12(10), pp.899~900 (2015)
  3. Hernán MA, "Causal knowledge as a prerequisite for confounding evaluation : an application to birth defects epidemiology", Am J Epidemiol, 155(2), pp.176~184 (2002)
  4. "Causal inference: what If"[URL]
  5. Sjölander A, "Regression standardization with the R package stdReg", Eur J Epidemiol, 31(6), pp.563~574 (2016)
  6. Hernán MA, "A structural approach to selection bias", Epidemiology, 15(5), pp.615~625 (2004)
  7. Cole SR, "Illustrating bias due to conditioning on a collider", Int J Epidemiol, 39(2), pp.417~420 (2010)
  8. Shrier I, "Reducing bias through directed acyclic graphs", BMC Med Res Methodol, 8, pp.70~ (2008)
  9. Westreich D, "Invited commentary : positivity in practice", Am J Epidemiol, 171(6), pp.674~677 (2010)
  10. Song BG, "A comparison of factors associated with the temporal improvement in the overall survival of BCLC stage 0 hepatocellular carcinoma patients", Dig Liver Dis, 53(2), pp.210~215 (2021)
  11. Nowok B, "synthpop : Bespoke creation of synthetic data in R", J Stat Softw, 74(11), pp.1~26 (2016)
  12. Kim GA, "Radiofrequency ablation as an alternative to hepatic resection for single small hepatocellular carcinomas", Br J Surg, 103(1), pp.126~135 (2016)
  13. "Drawing and analyzing causal DAGs with DAGitty" (2015)[URL]
  14. Judea Pearl, "Causal inference in statistics: a primer", pp.1~136 (2016), Wiley
  15. Thabane L, "A tutorial on sensitivity analyses in clinical trials: the what, why, when and how", BMC Med Res Methodol, 13, pp.92~ (2013)
  16. Gharibzadeh S, "Standardization as a tool for causal inference in medical research", Arch Iran Med, 19(9), pp.666~670 (2016)
  17. Keiding N, "Standardization and control for confounding in observational studies : a historical perspective", Stat Sci, 29(4), pp.529~558 (2014)
  18. Ferguson KD, "Evidence synthesis for constructing directed acyclic graphs(ESC-DAGs) : a novel and systematic method for building directed acyclic graphs", Int J Epidemiol, 49(1), pp.322~329 (2020)
  19. Hernán MA, "Estimating causal effects from epidemiological data", J Epidemiol Community Health, 60(7), pp.578~586 (2006)
  20. Stuart EA, "Matching methods for causal inference : a review and a look forward", Stat Sci, 25(1), pp.1~21 (2010)

관련 논문AI추천

이 간행물의 다른 논문 (9건)