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Pre-exposure Prophylaxis Adherence Among Men Who Have Sex With Men: A Systematic Review and Meta-analysis

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Objectives: The effectiveness and efficiency of pre-exposure prophylaxis (PrEP) in reducing the transmission of human immunodeficiency virus (HIV) among men who have sex with men (MSM) relies on how widely it is adopted and adhered to, particularly among high-risk groups of MSM. The meta-analysis aimed to collect and analyze existing evidence on various factors related to PrEP adherence in MSM, including demographic characteristics, sexual behaviors, substance use, and psychosocial factors.Methods: The meta-analysis followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The search included articles published between January 2018 and December 2022, obtained from the PubMed, ScienceDirect, and Scopus databases. The studies that were included in the analysis reported the proportion of MSM who demonstrated adherence to PrEP and underwent quality appraisal using the Newcastle-Ottawa Scale.Results: Of the 268 studies initially identified, only 12 met the inclusion criteria and were included in the final meta-analysis. The findings indicated that education (odds ratio [OR], 1.64; 95% confidence interval [CI], 1.12 to 2.40), number of sexual partners (OR, 1.16; 95% CI, 1.02 to 1.31), engaging in sexual activities with an human immunodeficiency virus-positive partner (OR, 1.59; 95% CI, 1.16 to 2.26), substance use (OR, 0.83; 95% CI, 0.70 to 0.99), and lower levels of depression (OR, 0.55; 95% CI, 0.37 to 0.82) were associated with higher rates of PrEP adherence among MSM.Conclusions: Despite these findings, further research is necessary to investigate PrEP adherence more comprehensively. The findings of this meta-analysis can be utilized to inform interventions aimed at improving PrEP adherence among MSM and provide directions for future research in this area.

Abstract

Objectives: The effectiveness and efficiency of pre-exposure prophylaxis (PrEP) in reducing the transmission of human immunodeficiency virus (HIV) among men who have sex with men (MSM) relies on how widely it is adopted and adhered to, particularly among high-risk groups of MSM. The meta-analysis aimed to collect and analyze existing evidence on various factors related to PrEP adherence in MSM, including demographic characteristics, sexual behaviors, substance use, and psychosocial factors.Methods: The meta-analysis followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The search included articles published between January 2018 and December 2022, obtained from the PubMed, ScienceDirect, and Scopus databases. The studies that were included in the analysis reported the proportion of MSM who demonstrated adherence to PrEP and underwent quality appraisal using the Newcastle-Ottawa Scale.Results: Of the 268 studies initially identified, only 12 met the inclusion criteria and were included in the final meta-analysis. The findings indicated that education (odds ratio [OR], 1.64; 95% confidence interval [CI], 1.12 to 2.40), number of sexual partners (OR, 1.16; 95% CI, 1.02 to 1.31), engaging in sexual activities with an human immunodeficiency virus-positive partner (OR, 1.59; 95% CI, 1.16 to 2.26), substance use (OR, 0.83; 95% CI, 0.70 to 0.99), and lower levels of depression (OR, 0.55; 95% CI, 0.37 to 0.82) were associated with higher rates of PrEP adherence among MSM.Conclusions: Despite these findings, further research is necessary to investigate PrEP adherence more comprehensively. The findings of this meta-analysis can be utilized to inform interventions aimed at improving PrEP adherence among MSM and provide directions for future research in this area.

참고문헌 (40)

  1. "HIV and AIDS" (2018)[URL]
  2. Ochonye B, "Sexual practices, sexual behavior and HIV risk profile of key populations in Nigeria", BMC Public Health, 19(1), pp.1210~ (2019)[DOI]
  3. Risher K, "HIV treatment cascade in MSM, people who inject drugs, and sex workers", Curr Opin HIV AIDS, 10(6), pp.420~429 (2015)[DOI]
  4. "Preexposure prophylaxis for the prevention of HIV infection in the United States—2017 update: a clinical practice guideline" (2018)[URL]
  5. Grulich AE, "Population-level effectiveness of rapid, targeted, high-coverage roll-out of HIV pre-exposure prophylaxis in men who have sex with men : the EPIC-NSW prospective cohort study", Lancet HIV, 5(11), pp.e629~e637 (2018)[DOI]
  6. Buchbinder SP, "Maximizing the benefits of HIV preexposure prophylaxis", Top Antivir Med, 25(4), pp.138~142 (2018)
  7. Gillespie D, "PrEP use, sexual behaviour, and PrEP adherence among men who have sex with men living in Wales prior to and during the COVID-19 pandemic", AIDS Behav, 26(8), pp.2746~2757 (2022)[DOI]
  8. Vuylsteke B, "Daily and event-driven pre-exposure prophylaxis for men who have sex with men in Belgium : results of a prospective cohort measuring adherence, sexual behaviour and STI incidence", J Int AIDS Soc, 22(10), pp.e25407~ (2019)[DOI]
  9. Qu D, "Adherence to pre-exposure prophylaxis among men who have sex with men : a prospective cohort study", Int J Infect Dis, 75, pp.52~59 (2018)[DOI]
  10. Page MJ, "The PRISMA 2020 statement : an updated guideline for reporting systematic reviews", Int J Surg, 88, pp.105906~ (2021)[DOI]
  11. Stang A, "Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses", Eur J Epidemiol, 25(9), pp.603~605 (2010)[DOI]
  12. Higgins JP, "Measuring in consistency in meta-analyses", BMJ, 327(7414), pp.557~560 (2003)[DOI]
  13. Eubanks A, "Socio-behavioral correlates of pre-exposure prophylaxis use and correct adherence in men who have sex with men in West Africa", BMC Public Health, 22(1), pp.1832~ (2022)[DOI]
  14. Gao Y, "Medication non-adherence and condomless anal intercourse increased substantially during the COVID-19 pandemic among MSM PrEP users : a retrospective cohort study in four Chinese metropolises", Front Med(Lausanne), 9, pp.738541~ (2022)[DOI]
  15. Grinsztejn B, "Retention, engagement, and adherence to pre-exposure prophylaxis for men who have sex with men and transgender women in PrEP Brasil : 48 week results of a demonstration study", Lancet HIV, 5(3), pp.e136~e145 (2018)[DOI]
  16. Hojilla JC, "Skating on thin ice : stimulant use and sub-optimal adherence to HIV pre-exposure prophylaxis", J Int AIDS Soc, 21(3), pp.e25103~ (2018)[DOI]
  17. Liu J, "Risk management on pre-exposure prophylaxis adherence of men who have sex with multiple men : a multicenter prospective cohort study", Risk Manag Healthc Policy, 14, pp.1749~1761 (2021)[DOI]
  18. Monteiro Spindola Marins L, "Factors associated with self-reported adherence to daily oral pre-exposure prophylaxis among men who have sex with man and transgender women : PrEP Brasil study", Int J STD AIDS, 32(13), pp.1231~1241 (2021)[DOI]
  19. Okafor CN, "Brief report : associations between self-reported substance use behaviors and PrEP acceptance and adherence among black MSM in the HPTN 073 study", J Acquir Immune Defic Syndr, 85(1), pp.23~29 (2020)[DOI]
  20. Seekaew P, "Correlates of nonadherence to key population-led HIV pre-exposure prophylaxis services among Thai men who have sex with men and transgender women", BMC Public Health, 19(1), pp.328~ (2019)[DOI]
  21. Wang H, "Risk-taking behaviors and adherence to HIV pre-exposure prophylaxis in users of geosocial networking apps : real-world, multicenter study", J Med Internet Res, 22(10), pp.e22388~ (2020)[DOI]
  22. Wheeler DP, "Pre-exposure prophylaxis initiation and adherence among Black men who have sex with men(MSM)in three US cities : results from the HPTN 073 study", J Int AIDS Soc, 22(2), pp.e25223~ (2019)[DOI]
  23. Whitfield DL, "Risk compensation in HIV PrEP adherence among Black men who have sex with men in HPTN 073 study", AIDS Care, 33(5), pp.633~638 (2021)[DOI]
  24. Wu HJ, "Imperfect adherence in real life : a prevention-effective perspective on adherence to daily and event-driven HIV pre-exposure prophylaxis among men who have sex with men-a prospective cohort study in Taiwan", J Int AIDS Soc, 24(5), pp.e25733~ (2021)[DOI]
  25. Aderemi-Williams RI, "Adolescents and young adults knowledge, adherence and experiences while on antiretroviral therapy in a tertiary hospital in Lagos, Nigeria : a mixed-method study", J Int Assoc Provid AIDS Care, 20, pp.23259582211062754~ (2021)[DOI]
  26. Musinguzi N, "Adherence to recommendations for ART and targeted PrEP use among HIV serodiscordant couples in East Africa : the"PrEP as a bridge to ART"strategy", BMC Public Health, 20(1), pp.1621~ (2020)[DOI]
  27. Sack DE, "Pre-exposure prophylaxis use among HIV serodiscordant couples : a qualitative study in Mozambique", Glob Health Action, 14(1), pp.1940764~ (2021)[DOI]
  28. Gebru NM, "Substance use and adherence to HIV pre-exposure prophylaxis in studies enrolling men who have sex with men and transgender women : a systematic review", AIDS Behav, 27(7), pp.2131~2162 (2023)[DOI]
  29. Smith R, "Imprecise action selection in substance use disorder : evidence for active learning impairments when solving the explore-exploit dilemma", Drug Alcohol Depend, 215, pp.108208~ (2020)[DOI]
  30. Pasipanodya EC, "Greater levels of self-reported adherence to pre-exposure prophylaxis(PrEP)are associated with increased condomless sex among men who have sex with men", AIDS Behav, 24(11), pp.3192~3204 (2020)[DOI]
  31. Viamonte M, "Running with scissors : a systematic review of substance use and the pre-exposure prophylaxis care continuum among sexual minority men", Curr HIV, 2022, pp.19(4), 235~250
  32. Hillis A, "Pre-exposure prophylaxis(PrEP)for HIV prevention among men who have sex with men(MSM) : a scoping review on PrEP service delivery and programming", AIDS Behav, 24(11), pp.3056~3070 (2020)[DOI]
  33. Westmoreland DA, "Sociocultural influences on attitudes towards pre-exposure prophylaxis(PrEP), history of PrEP use, and future PrEP use in HIV-vulnerable cisgender men who have sex with men across the U. S", Ann LGBTQ Public Popul Health, 1(2), pp.128~158 (2020)[DOI]
  34. Shuper PA, "Alcohol consumption, substance use, and depression in relation to HIV pre-exposure prophylaxis(PrEP)nonadherence among gay, bisexual, and other men-who-have-sex-with-men", BMC Public Health, 20(1), pp.1782~ (2020)[DOI]
  35. Colson PW, "Adherence to pre-exposure prophylaxis in black men who have sex with men and transgender women in a community setting in Harlem, NY", AIDS Behav, 24(12), pp.3436~3455 (2020)[DOI]
  36. Velloza J, "Effect of depression on adherence to oral PrEP among men and women in East Africa", J Acquir Immune Defic Syndr, 79(3), pp.330~338 (2018)[DOI]
  37. Velloza J, "The effect of depression on adherence to HIV pre-exposure prophylaxis among high-risk South African women in HPTN 067", ADAPT, 2020, pp.24(7), 2178~2187
  38. Peng L, "Willingness to use and adhere to HIV pre-exposure prophylaxis(PrEP)among men who have sex with men(MSM)in China", Int J Environ Res Public Health, 16(14), pp.2620~ (2019)[DOI]
  39. Soares F, "Perceived risk of HIV infection and acceptability of PrEP among men who have sex with men in Brazil", Arch Sex Behav, 52(2), pp.773~782 (2023)[DOI]
  40. Mayer KH, "Barriers to the wider use of pre-exposure prophylaxis in the United States : a narrative review", Adv Ther, 37(5), pp.1778~1811 (2020)[DOI]

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