본문 바로가기
KERD
논문KCI 등재

조갑진균증의 치료와 환자 순응도에 대한 고찰

A Study of Treatment and Compliance on Onychomycosis

김기홍|이광훈|안규중|원영호|서무규|이양원
대한의진균학회 (The Korean Society for Medical Mycology)|2005.09|대한의진균학회지 (Journal of Mycology and Infection)|제10권 제3호|pp. 83-90

1

조회

0

다운로드

4

인용

0

참고문헌

주제분류미생물학

초록

Abstract

Onychomycosis is a common infection of the nail, with its prevalence estimated at 20 percent. However, a significant proportion of patients, perhaps as high as 20~40%, is classified as treatment failures and/or relapse following treatment. Several factors such as antifungal resistance, dermatophytoma, preexisting nail dystrophy, reinfection from the surrounding infected tissue can influence the success of a particular monotherapy. Therefore, the combination of antifungal drugs to produce synergistic activity is one possible advance towards achieving higher cure rates. The combination therapies have been known to increase antifungal spectrum and potency of drugs, facilitate drug delivery and reduce fungal load in nail plate. Their final goals are to increase a tolerance and maximize the therapeutic efficacy. Considering the special circumstance of the nail, the oral/topical combination is the most appropriate, for it increases drug concentration in the nail plate by mutual complementary cooperation. Treatment of onychomycosis requires long-term systemic medication of antifungal agent, and its complete cure rates were only 30~50%. Clinical success rate is determined by patients compliance which depends on treatment method and period. In practice, compliance of long-term treatment was very low, possibly attributable to longer treatment duration. Another challenge was relapse and/or reinfection after cure. The authors have attempted to address the issue concerning the method of treatment and duration of action for oral antifungal agents commonly used in practice today, and whether there is a statistically¬significant difference among those drugs, based on the studies analyzing patient compliance.

참고문헌 (27)

  1. "Onychomycosis:diagnosis and topical therapy", 15, pp.71~77 (2002)
  2. "Diversified treatments of tinea unguium", 43, pp.85~89 (2002)
  3. "Topical antifungal drugs for the treatment of onychomycosis:an overview of current strategies for monotherapy and combination therapy", 19, pp.21~29 (2005)
  4. "Treatment of onychomycosis pros and cons of antifungal agents", pp.25~30
  5. "The use of topical therapies to treat onychomycosis", 21, pp.481~489 (2003)
  6. "New insights into the effect of amorolfine nail lacquer", 48, pp.91~94 (2005)
  7. "Guidelines for treatment of onychomycosis", 148, pp.402~410 (2003)
  8. "Noninvasive CO2 laser fene- stration improves treatment of onychomycosis", 10, pp.123~124 (1992)
  9. "Onychomycosis in children:treatment with bifonazole-urea", 17, pp.310~314 (2000)
  10. "Bioadhesive patch-based delivery of 5 aminolevulinic acid to the nail for photodynamic therapy of onychomycosis", 103, pp.381~392 (2005)
  11. "Antifungal effect of 5-aminolevulinic acid PDT in Trichophyton rubrum", 48, pp.101~107 (2005)
  12. "Low-voltage direct current as a fungicidal agent for treating onychomycosis", 94, pp.565~572 (2004)
  13. "The future of onychomycosis therapy may involve a combination of approaches", 145(60), pp.3~8 (2001)
  14. "Topical antifungal drugs for the treatment of onychomycosis:an overview of current strategies for monotherapy and combination therapy", 19, pp.21~29 (2005)
  15. "A plea to bridge the gap between antifungals and the management of onychomycosis", 2, pp.281~284 (2001)
  16. "A randomized trial of amo- rolfine 5% solution nail lacquer combined with oral terbinafine compared with terbinafine alone in the treatment of dermatophytic toenail onychomycoses affecting the matrix region", 142, pp.1177~1183 (2000)
  17. "Topical amorolfine for 15 months combined with 12 weeks of oral terbinafine a cost-effective treatment for onychomycosis", 145(60), pp.15~19
  18. "Combination therapy for onychomycosis", 149(65), pp.15~18 (2003)
  19. "New insights into the effect of amorolfine nail lacquer", 48, pp.91~94 (2005)
  20. "Testing of anti- fungal combinations against yeasts and dermatophy- tes", 15, pp.104~107 (2004)
  21. "Amorolfine and itraconazole combination for severe toenail onychomycosis results of an open randomized trial in Spain", 145(60), pp.21~26
  22. "A randomized trial of amorolfine 5% solution nail lacquer in association with itraconazole pulse therapy compared with itraconazole alone in the treatment of candida fingernail onychomycosis", 149, pp.151~156 (2003)
  23. "조갑진균증에서 amorolfine 5% nail lacquer 와 itra- conazole 병합요법의 치료효과에 관한 연구", 40(2), pp.112~ (2002)
  24. "족부 조갑진균증 치료에서 수종 경구용 항진균제에 따른 환자 순응도에 대한 후향적 연구", 7, pp.149~154 (2002)
  25. "대구지역 발톱 조갑진균증 환자에서 terbina- fine 연속요법과 itraconazole 주기요법에 대한 치료 완료율 비교", 7, pp.217~223 (2002)
  26. "Onychomycosis caused by nondermatophytic molds:Clinical features and response to treatment of 59 cases", 42, pp.217~224 (2000)
  27. "Autosomal domi- nant pattern of distal subungual onychomycosis cau- sed by Trichophyton rubrum", 34, pp.302~304 (1996)

관련 논문AI추천

조갑진균증 치료의 순응도와 장기적 추적 관찰김지은, 박현정, 이준영, 조백기대한의진균학회 · 대한의진균학회지2003 · 제8권 제3호족부 조갑진균증 치료에서 수종 경구용 항진균제에 따른 환자 순응도에 대한 후향적 연구안규중, 이양원, 정성태대한의진균학회 · 대한의진균학회지2002 · 제7권 제3호발톱 조갑진균증에서 항진균제 경구 치료와 국소제 병용 치료의 순응도 및 완치율 비교김기홍, 김현철, 신동훈, 정기백, 최종수대한의진균학회 · 대한의진균학회지2002 · 제7권 제1호조갑진균증의 임상적 고찰 : 조갑진균증의 치료에 영향을 주는 인자와 그에 따른 치유율 비교김덕한, 박현정, 이준영, 조백기대한의진균학회 · 대한의진균학회지2005 · 제10권 제2호조갑진균증의 임상적 고찰권경술, 박장규, 유희준대한의진균학회 · 대한의진균학회지2005 · 제10권 제2호조갑진균증의 진균학적 고찰문기찬, 조백기대한의진균학회 · 대한의진균학회지2005 · 제10권 제2호

이 간행물의 다른 논문 (2건)

흑색진균에 의한 감염증이용환, 서무규pp. 73-82안면 백선의 임상적 특징과 진균학적 소견신동훈, 김기홍, 최종수, 김우진pp. 91-100
원문 보기