Aspergillus sydowii 감염에 의한 발톱진균증 1예
A Case of Toenail Onychomycosis Due to Aspergillus sydowii Infection
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Onychomycosis is caused by dermatophytes usually, but some species of nondermatophytic moldsand yeasts are also associated with invasion of nails. Aspergillus sydowii is a nondermatophytic moldwhich is opportunistic filamentous fungus in all environments. We report a case of onychomycosis causedby A. sydowii in a 65-year-old male. The patient showed yellowish discoloration with hyperkeratoticchange on the distal and lateral portion of both great toenails. Direct microscopic examination of scrapingon the potassium hydroxide preparation revealed dichotomous septate hyphae and repeated cultures onSabouraud dextrose agar showed the same blue green velvety colonies. Biseriate phialides that coverentire vesicle with conidial structure resembling Penicillium were shown in the slide culture. The DNAsequence of internal transcribed spacer (ITS) region of clinical sample was 99% match to that of A. sydowii strain XWSFJJ1 (GenBank accession number FJ461692). We confirmed A. sydowii by KOHmount, colony, light microscopic morphology and DNA sequence analysis. The patient was treated with250 mg oral terbinafine daily and topical 5% amorolfine nail lacquer for 3 months.
Abstract
Onychomycosis is caused by dermatophytes usually, but some species of nondermatophytic moldsand yeasts are also associated with invasion of nails. Aspergillus sydowii is a nondermatophytic moldwhich is opportunistic filamentous fungus in all environments. We report a case of onychomycosis causedby A. sydowii in a 65-year-old male. The patient showed yellowish discoloration with hyperkeratoticchange on the distal and lateral portion of both great toenails. Direct microscopic examination of scrapingon the potassium hydroxide preparation revealed dichotomous septate hyphae and repeated cultures onSabouraud dextrose agar showed the same blue green velvety colonies. Biseriate phialides that coverentire vesicle with conidial structure resembling Penicillium were shown in the slide culture. The DNAsequence of internal transcribed spacer (ITS) region of clinical sample was 99% match to that of A. sydowii strain XWSFJJ1 (GenBank accession number FJ461692). We confirmed A. sydowii by KOHmount, colony, light microscopic morphology and DNA sequence analysis. The patient was treated with250 mg oral terbinafine daily and topical 5% amorolfine nail lacquer for 3 months.
참고문헌 (24)
- Schieke SM, "Fitzpatrick's dermatology in general medicine", pp.2278~2297 (2012), McGraw-Hill
- Gupta AK, "Nondermatophyte onychomycosis", Dermatol Clin, 21, pp.257~268 (2003)
- Romano C, "Retrospective study of onychomycosis in Italy: 1985-2000", Mycoses, 48, pp.42~44 (2005)
- Gupta M, "Onychomycosis: Clinico-mycologic study of 130 patients from Himachal Pradesh, India", Indian J Dermatol Venereol Leprol, 73, pp.389~392 (2007)
- Gianni C, "Clinical and histological aspects of toenail onychomyosis caused by Aspergillus spp.:34 cases treated with weekly intermittent terbinafine", Dermatology, 209, pp.104~110 (2004)
- Hilmioqlu-Polat S, "Non-dermatophytic molds as agents of onychomycosis in Izmir, Turkey - a prospective study", Mycopathologia, 160, pp.125~128 (2005)
- Suh SB, "A case of onychomycosis caused by Aspergillus sydowi", Korean J Dermatol, 6, pp.39~43 (1968)
- Suh JC, "A simple detection method of resistance to the treatment of onychomycosis: a case report of Aspergillus sydowii onychomycosis", Ann Dermatol, 13, pp.62~65 (2001)
- Lim SW, "Clinical features and identification of etiologic agents in onychomycosis", Korean J Dermatol, 42, pp.53~60 (2004)
- Tosti A, "Onychomycosis caused by nondermatophytic molds: clinical features and response to treatment 59 cases", J Am Acad Dermatol, 42, pp.217~224 (2000)
- Gianni C, "Non-dermatophytic onychomycosis. An underestimated entity? A study of 51 cases", Mycoses, 43, pp.29~33 (2000)
- Summerbell RC, "Onychomycosis, tinea pedis and tinea manuum caused by nondermatophytic filamentous fungi", Mycoses, 32, pp.609~619 (1989)
- Rippon JW, "Medical mycology: The pathogenic fungi and the pathogenic actinomycetes", pp.618~650 (1988), WB Saunders
- Takahata Y, "A case of onychomycosis due to Aspergillus sydowii diagnosed using DNA sequence analysis", 51, pp.170~173 (2008)
- Tosti A, "Proximal subungual onychomycosis due to Aspergillus niger: report of two cases", Br J Dermatol, 139, pp.156~157 (1998)
- Grover S, "Clinicomycological evaluation of onychomycosis at banglore and Jorhat", Indian J Dermatol Venerol Leprol, 69, pp.284~286 (2003)
- De Hoog GS, "Atlas of clinical fungi", pp.442~519 (2000), Centraalbureau voor Schimmelcultures
- Sung Min Hwang, "Onychomycosis Due to Nondermatophytic Molds", Annals of Dermatology, 24(2), pp.175~180 (2012), 대한피부과학회[DOI]
- English MP, "Nails and fungi", Br J Dermatol, 94, pp.697~701 (1976)
- Makimura K, "Phylogenetic classification and species identification of dermatophyte strains based on DNA sequences of nuclear ribosomal internal transcribed spacer 1 regions", J Clin Microbiol, 37, pp.920~924 (1999)
- 고종현, "분자생물학적 방법으로 진단한 백선의 중복감염 1예", 대한의진균학회지, 15(3), pp.150~155 (2010), 대한의진균학회
- Kwon-Chung KJ, "Medical mycology", pp.201~247 (1992), Lea & Febiger
- Baran R, "A new classification of onychomycosis", Br J Dermatol, 139, pp.567~571 (1998)
- Nolting S, "Terbinafine in onychomycosis with involvement by nondermatophytic fungi", Br J Dermatol, 130(Suppl 43), pp.16~21 (1994)