골수이식 환자에서 발생한 크립토콕쿠스 감염 증례보고와 문헌고찰
Cryptococcus Species Infection in a Bone Marrow Transplant Patient and Review of the Literature
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Cryptococcosis is caused by several Cryptococcus species, including C. neoformans and C. gattii. Skin involvement is seen in 10~20% of systemic cryptococcosis. There are also rare cases of primary cutaneous cryptococcosis in which skin-penetrating trauma is the alleged mechanism of infection. A 16-year-old male presented with multiple, 0.2~0.3 cm-sized, brownish papules on the whole body for 2 weeks. He had past history of acute lymphoblastic leukemia and received bone marrow transplant 1 year ago. After leukemia had recurred 1 month ago and after chemotherapy, multiple brownish papules developed. Histopathologic examinations revealed narrow-based budding yeasts in hematoxylin and eosin, Periodic acid-Schiff, and Gomori methenamine silver stains. Also in mucicarmine stain there were pink-colored capsules around the cell walls. Finally it was diagnosed as deep fungal infection due to Cryptococcus species. In spite of administrating fluconazole, the patient expired due to respiratory failure caused by pneumonia. Herein, we report a case of Cryptococcus species infection in a bone marrow transplant patient.
Abstract
Cryptococcosis is caused by several Cryptococcus species, including C. neoformans and C. gattii. Skin involvement is seen in 10~20% of systemic cryptococcosis. There are also rare cases of primary cutaneous cryptococcosis in which skin-penetrating trauma is the alleged mechanism of infection. A 16-year-old male presented with multiple, 0.2~0.3 cm-sized, brownish papules on the whole body for 2 weeks. He had past history of acute lymphoblastic leukemia and received bone marrow transplant 1 year ago. After leukemia had recurred 1 month ago and after chemotherapy, multiple brownish papules developed. Histopathologic examinations revealed narrow-based budding yeasts in hematoxylin and eosin, Periodic acid-Schiff, and Gomori methenamine silver stains. Also in mucicarmine stain there were pink-colored capsules around the cell walls. Finally it was diagnosed as deep fungal infection due to Cryptococcus species. In spite of administrating fluconazole, the patient expired due to respiratory failure caused by pneumonia. Herein, we report a case of Cryptococcus species infection in a bone marrow transplant patient.
참고문헌 (23)
- Guarner J, "Histopathologic diagnosis of fungal infections in the 21st century", Clin Microbiol Rev, 24, pp.247~280 (2011)
- Fernandez-Flores A, "Morphological findings of deep cutaneous fungal infections", Am J Dermatopathol, 36, pp.531~553 (2014)
- Chung WG, "A case of cutaneous cryptococcosis resembling verrucous granuloma", Korean J Med Mycol, 7, pp.42~46 (2002)
- Kim HJ, "Two cases of cutaneous cryptococcosis mimicking cellulitis", Korean J Med Mycol, 3, pp.190~194 (1998)
- Perfect JR, "Cryptococcosis diagnosis and treatment: What do we know now", Fungal Genet Biol, 78, pp.49~54 (2015)
- Desalermos A, "Update on the epidemiology and management of cryptococcal meningitis", Expert Opin Pharmacother, 13, pp.783~789 (2012)
- Pukkila-Worley R, "Epidemiology and management of cryptococcal meningitis: developments and challenges", Expert Opin Pharmacother, 9, pp.551~560 (2008)
- Christianson JC, "Primary cutaneous cryptococcosis in immunocompetent and immunocompromised hosts", Med Mycol, 41, pp.177~188 (2003)
- Yuge S, "Cutaneous cryptococcosis in an immunocompetent host", Acta Derm Venereol, 86, pp.165~166 (2006)
- Neuville S, "Primary cutaneous cryptococcosis:a distinct clinical entity", Clin Infect Dis, 36, pp.337~347 (2003)
- Hernandez AD, "Cutaneous cryptococcosis", Dermatol Clin, 7, pp.269~274 (1989)
- Perfect JR, "Clinical practice guidelines for the management of cryptococcal disease:2010 update by the infectious diseases society of america", Clin Infect Dis, 50, pp.291~322 (2010)
- Chen SC, "Consensus guidelines for the treatment of yeast infections in the haematology, oncology and intensive care setting, 2014", Intern Med J, 44, pp.1315~1332 (2014)
- Kim YS, "Cryptococcal infection in renal trasnplant patient", J Korean Soc Transplant, 4, pp.121~130 (1990)
- Choi SC, "A disseminated crytococcosis after renal transplantation", J Wonkwang Med Sci, 24, pp.211~217 (1992)
- Kim KJ, "A case of cryptococcosis with skin involvement in a liver transplant recipient", Korean J Dermatol, 39, pp.1446~1448 (2001)
- Ko Y-H, "A case of cryptococcal spondylitis following allogeneic hematopoietic stem cell transplantation", Korean J Infect Dis, 33, pp.298~301 (2001)
- Park JH, "Cryptococcal meningitis in cardiac transplant patients", J Korean Soc Chemother, 19, pp.341~347 (2001)
- 김인택, "신장이식 환자에서의 Cryptococcal chorioretinitis 1예", 대한안과학회지, 43(5), pp.19~926 (2002), 대한안과학회
- Lee YA, "First report of Cryptococcus albidus -induced disseminated cryptococcosis in a renal transplant recipient", Korean J Med Mycol, 19, pp.53~57 (2004)
- Hyun Y-Y, "Asymptomatic cryptococcus and subsequent symptomatic tuberculosis infection in a renal transplant patient", J Korean Soc Transplant, 20, pp.117~120 (2006)
- 전지민, "신이식 환자에서 발생한 무증상 파종성 크립토콕쿠스증 1예", Kidney Research and Clinical Practice, 29(2), pp.310~314 (2010), 대한신장학회
- Lee SK, "Disseminated cryptococcosis with cutaneous manifestation in a renal transplant recipient", J Korean Soc Transplant, 27, pp.132~137 (2013)