Epidemiology and Identification of Organisms Causing Superficial Dermatomycoses at Tertiary Hospitals in Korea: A Prospective Multicenter Study
2
조회
0
다운로드
3
인용
0
참고문헌
키워드
초록
Background: Superficial dermatomycoses are fungal infections of the skin, hair, or nails and are most commonly caused by dermatophytes. Superficial dermatomycoses are very common diseases in the field of dermatology; however, their prevalence and clinical characteristics vary with geographical areas and populations. Moreover, pathogenic species change constantly over time. Objective: This multicenter study aimed to investigate the epidemiologic and clinical findings of tinea corporis, tinea faciale, and tinea capitis in Korea during 2016-2017. In addition, we sought to identify the pathogenic organism causing these three different types of fungal infections. Methods: Total 453 patients from the dermatology clinics of 13 tertiary hospitals in Korea were enrolled in this study. Information regarding demographic characteristics, comorbidities, occupation, family history of superficial dermatomycoses, suspected routes of infection, and treatment was collected. Fungal cultures and molecular analyses were performed for patients with tinea corporis, tinea faciale, and tinea capitis. Results: Of the 453 patients, 275 were men and 178 were women. With respect to past history, 214 patients (53.4%) had at least one comorbidity. Tinea corporis (27.3%) was the most common form of superficial dermatomycosis, followed by tinea pedis (23.2%) and tinea unguium (16.6%). Overall, the fungal culture positivity was 77.8% (126/162). Trichophyton rubrum was the most common causative organism for tinea corporis (66.7%, 68/80) and tinea faciale (43.8%, 14/23), while Microsporum canis was the most common causative organism for tinea capitis (36.7%, 11/23). Conclusion: Trichophyton rubrum was consistently the most common causative organism of superficial dermatomycoses, except for tinea capitis in Korea.
Abstract
Background: Superficial dermatomycoses are fungal infections of the skin, hair, or nails and are most commonly caused by dermatophytes. Superficial dermatomycoses are very common diseases in the field of dermatology; however, their prevalence and clinical characteristics vary with geographical areas and populations. Moreover, pathogenic species change constantly over time. Objective: This multicenter study aimed to investigate the epidemiologic and clinical findings of tinea corporis, tinea faciale, and tinea capitis in Korea during 2016-2017. In addition, we sought to identify the pathogenic organism causing these three different types of fungal infections. Methods: Total 453 patients from the dermatology clinics of 13 tertiary hospitals in Korea were enrolled in this study. Information regarding demographic characteristics, comorbidities, occupation, family history of superficial dermatomycoses, suspected routes of infection, and treatment was collected. Fungal cultures and molecular analyses were performed for patients with tinea corporis, tinea faciale, and tinea capitis. Results: Of the 453 patients, 275 were men and 178 were women. With respect to past history, 214 patients (53.4%) had at least one comorbidity. Tinea corporis (27.3%) was the most common form of superficial dermatomycosis, followed by tinea pedis (23.2%) and tinea unguium (16.6%). Overall, the fungal culture positivity was 77.8% (126/162). Trichophyton rubrum was the most common causative organism for tinea corporis (66.7%, 68/80) and tinea faciale (43.8%, 14/23), while Microsporum canis was the most common causative organism for tinea capitis (36.7%, 11/23). Conclusion: Trichophyton rubrum was consistently the most common causative organism of superficial dermatomycoses, except for tinea capitis in Korea.
참고문헌 (23)
- 김상하, "Epidemiological Characterization of Skin Fungal Infections Between the Years 2006 and 2010 in Korea", Osong Public Health and Research Perspectives, 6(6), pp.341~345 (2015), 질병관리청
- Agarwal US, "Clinico-mycological study of dermatophytes in a tertiary care centre in Northwest India", Indian J Dermatol Venereol Leprol, 80, pp.194~ (2014)
- Suh SB, "Dermatophytosis in Korea", Kyungpook Univ Med J, 59, pp.1~33 (1959)
- Kim JS, "Clinical and mycological studies on dermatomycosis", Korean J Dermatol, 30, pp.68~75 (1992)
- 문현주, "피부진균증의 임상 및 균학적 관찰 (1991-2000)", 대한의진균학회지, 7(2), pp.78~85 (2002), 대한의진균학회
- Jo JH, "Diverse human skin fungal communities in children converge in adulthood", J Invest Dermatol, 136, pp.2356~2363 (2016)[DOI]
- Shivanna R, "Management of dermatophytosis in elderly and with systemic comorbidities", Clin Dermatol, 1, pp.38~41 (2017)[DOI]
- Jain A, "Emerging fungal infections among children: a review on its clinical manifestations, diagnosis, and prevention", J Pharm Bioallied Sci, 2, pp.314~320 (2010)[DOI]
- Nenoff P, "Mycology - an update. Part 1: Dermatomycoses: causative agents, epidemiology and pathogenesis", J Dtsch Dermatol Ges, 12, pp.188~209 (2014)
- Millikan LE, "Current concepts in systemic and topical therapy for superficial mycoses", Clin Dermatol, 28, pp.212~216 (2010)[DOI]
- Newland JG, "Update on terbinafine with a focus on dermatophytoses", Clin Cosmet Investig Dermatol, 2, pp.49~63 (2009)
- Gupta AK, "Itraconazole is effective in the treatment of tinea capitis caused by Microsporum canis", Pediatr Dermatol, 18, pp.519~522 (2001)[DOI]
- Dragos V, "Lack of efficacy of 6-week treatment with oral terbinafine for tinea capitis due to Microsporum canis in children", Pediatr Dermatol, 14, pp.46~48 (1997)[DOI]
- Mahajan S, "Clinico-mycological study of dermatophytic infections and their sensitivity to antifungal drugs in a tertiary care center", Indian J Dermatol Venereol Leprol, 83, pp.436~440 (2017)[DOI]
- Snyder JW, "Manual of clinical microbiology", pp.1767~1775 (2011), ASM Press
- 김형록, "Growth Features of Trichophyton rubrum on Potato Dextrose Agar-Corn Meal-Tween 80 Plate", 대한의진균학회지, 21(3), pp.103~104 (2016), 대한의진균학회[DOI]
- 이원주, "Increasing Prevalence of Trichophyton rubrum Identified through an Analysis of 115,846 Cases over the Last 37 Years", Journal of Korean Medical Science, 30(5), pp.639~643 (2015), 대한의학회
- 장수정, "체부 백선의 임상 및 진균학적 고찰", 대한피부과학회지, 42(2), pp.166~172 (2004), 대한피부과학회
- 김인용, "대구 지역 얼굴백선의 임상 및 진균학적 고찰", 대한의진균학회지, 20(3), pp.63~69 (2015), 대한의진균학회[DOI]
- 김상민, "두부백선의 임상 및 진균학적 고찰", 대한의진균학회지, 11(4), pp.184~190 (2006), 대한의진균학회
- Atzori L, "Tinea faciei due to Microsporum canis in children: a survey of 46 cases in the District of Cagliari (Italy)", Pediatr Dermatol, 29, pp.409~413 (2012)[DOI]
- Hay RJ, "Tinea capitis in Europe: new perspective on an old problem", J Eur Acad Dermatol Venereol, 15, pp.229~233 (2001)[DOI]
- Ginter-Hanselmayer G, "Epidemiology of tinea capitis in Europe: current state and changing patterns", Mycoses, 50, pp.6~13 (2007)[DOI]