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지루피부염에서 Itraconazole의 치료 효과

Therapeutic Effect of Itraconazole in Seborrheic Dermatitis

김철우|김광호|안규중|김광중|박은주
대한의진균학회 (The Korean Society for Medical Mycology)|2004.12|대한의진균학회지 (Journal of Mycology and Infection)|제9권 제4호|pp. 222-229

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참고문헌

주제분류미생물학

초록

Abstract

Background: Seborrheic dermatitis is a very common chronic inflammatory disease. The causal factor of the disease is still unknown, but early investigators focused on the role of Malassezia yeasts. These yeasts are also normal skin commensals, thus their importance as pathogens in this disorder came to be doubted. However, it was subsequently found that treatment of seborrheic dermatitis with an antifungal agent not only resulted in clinical improvement but also reduced the number of Malassezia yeasts on the skin. Object: The purpose of this study is to confirm relationship between seborrheric dermatits and Malassezia yeast, and to evaluate the therapeutic efficacy of oral itraconazole in the seborrheic dermatitis. Methods: Using the scrub-wash technique in the glabella and swabbing technique in the scalp, the number of cultured Malassezia yeasts were counted in 30 patients with seborrheic dermatitis and 20 control persons. The patients took itraconazole, 100mg/day, during 4weeks. The clinical and mycologic score were measured at the initial evaluation, followed after 2weeks and 4weeks Result: The number of Malassezia yeasts in patient with seborrheic dermatits were significantly higher than in normal control group. There was statistically significant decrease in the clinical and mycological score after a 4week trial of oral itraconazole in the seborrheic dermatitis group. Conclusion: This study indicates that Malassezia yeast may be one of the important causative factor of seborrheic dermatitis and itraconazole plays an important role in the treatment of seborrheic dermatitis.

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관련 논문AI추천

지루성 피부염의 최신 지견김규석, 김윤범, 김희정, 남혜정, 박외숙, 차재훈대한한방안이비인후피부과학회 · 한방안이비인후피부과학회지2006 · 제19권 제3호지루성피부염 치험1례이상곤, 임진호, 지선영, 황보민, 황순이대한한방안이비인후피부과학회 · 한방안이비인후피부과학회지2005 · 제18권 제3호Itraconazole 치료로 호전을 보인 두경부 피부염 1예노용관, 서성준, 안지영, 유광호, 홍창권대한의진균학회 · 대한의진균학회지2008 · 제13권 제3호영兒 脂漏性 皮膚炎에 대한 證例 1例김기봉, 김장현대한한방소아과학회 · 대한한방소아과학회지2006 · 제20권 제2호Malassezia 모낭염 병변에서 배양된 Malassezia 효모균의 분류안규중, 장수정, 최용범대한의진균학회 · 대한의진균학회지2003 · 제8권 제2호말라세지아 균주 6종에 대한 항진균제 시험관내 감수성 시험이양원대한의진균학회 · 대한의진균학회지2017 · 제22권 제1호

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