Fluconazole로 치료한 피부 알테나리아증 1예
A Case of Cutaneous Alternariosis Treated with Fluconazole
2
조회
0
다운로드
3
인용
0
참고문헌
키워드
초록
Alternaria is a common saprophytic fungus found in the environment such as soil, air, and a variety of objects. The cutaneous infection caused by this fungus occurs more frequent in patients with immunocompromission than in immunocompetent people. We report a case of cutaneous alternariosis in a 63-year-old woman presented with a tender erythematous patch on the right forearm. She was on medication only for hypertension. Histopathologic examination showed a dermal mixed-cell infiltrate including multinucleated giant cells. PAS staining revealed fungal elements in the dermis. Microscopic examination of the colonies showed muriform conidia. A diagnosis of cutaneous infection due to Alternaria species was made on the basis of the above mentioned findings. Oral administration of fluconazole revealed resolution of her cutaneous lesion.
Abstract
Alternaria is a common saprophytic fungus found in the environment such as soil, air, and a variety of objects. The cutaneous infection caused by this fungus occurs more frequent in patients with immunocompromission than in immunocompetent people. We report a case of cutaneous alternariosis in a 63-year-old woman presented with a tender erythematous patch on the right forearm. She was on medication only for hypertension. Histopathologic examination showed a dermal mixed-cell infiltrate including multinucleated giant cells. PAS staining revealed fungal elements in the dermis. Microscopic examination of the colonies showed muriform conidia. A diagnosis of cutaneous infection due to Alternaria species was made on the basis of the above mentioned findings. Oral administration of fluconazole revealed resolution of her cutaneous lesion.
참고문헌 (17)
- Pastor FJ, "Alternaria infections: laboratory diagnosis and relevant clinical features", Clin Microbiol Infect, 14, pp.734~746 (2008)
- Shugar MA, "Alternaria sinusitis", Ann Otol Rhinol Laryngol, 90, pp.251~254 (1981)
- Lyke KE, "A case of cutaneous ulcerative alternariosis: rare association with diabetes mellitus and unusual failure of itraconazole treatment", Clin Infect Dis, 32, pp.1178~1187 (2001)
- Gilaberte M, "Cutaneous alternariosis in transplant recipients: clinicopathologic review of 9 cases", J Am Acad Dermatol, 52, pp.653~659 (2005)
- Lee HJ, "A case of primary cutaneous alternariosis with iatrogenic cushing syndrome", Korean J Dermatol, 34, pp.495~499 (1996)
- Chung YL, "Spontaneously healed primary cutaneous alternariosis: Reports of 2 cases", Korean J Med Mycol, 4, pp.137~142 (1999)
- Ko JH, "A case of cutaneous alternariosis", Korean J Med Mycol, 7, pp.165~169 (2002)
- 김성진, "피부 Alternariosis 1예", 대한피부과학회지, 43(7), pp.957~960 (2005), 대한피부과학회
- 장재용, "간이식 환자에 발생한 피부 Alternariosis 1예", 대한의진균학회지, 11(3), pp.159~162 (2006), 대한의진균학회1
- 이재철, "Alternaria alternata에 의한 피부 Alternariosis 1예", 대한의진균학회지, 12(1), pp.27~30 (2007), 대한의진균학회1
- Gilmour TK, "Cutaneous alternariosis in a cardiac transplant recipient", Australas J Dermatol, 42, pp.46~49 (2001)
- Iwatsu T, "Cutaneous alternariosis", Arch Dermatol, 124, pp.1822~1825 (1988)
- Duffill MB, "Cutaneous phaeohyphomycosis due to Alternaria alternata responding to itraconazole", Clin Exp Dermatol, 18, pp.156~158 (1993)
- De Hoog GS, "Atlas of clinical fungi", Centraalbureau voor Schimmelcultures and Universitat Rovira i Virgili, 134~ (1995)
- Williams C, "Cutaneous infection with an Alternaria sp. In an immunocompetent host", Clin Exp Dermatol, 33, pp.440~442 (2008)
- Uenotsuchi T, "Cutaneous alternariosis with chronic granulomatous disease", Eur J Dermatol, 15, pp.406~408 (2005)
- Machet L, "Lorette G. Cutaneous alternariosis: role of corticosteroid-induced cutaneous fragility", Dermatology, 193, pp.342~344 (1996)