복분자뿌리추출물의 지루피부염 치료에의 활용가능성에 관한 연구
A Study of Potential Application of Rubus coreanus Miquel Extract for Seborrheic Dermatitis Treatment
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Background: Seborrheic dermatitis is chronic relapsing inflammatory skin disorder. Bokbunja (Rubus coreanus Miquel) is a wild berry to Rosaceae genus and also known to have an anti-inflammation effect. Objective: We were to determine the effect of Rubus coreanus Miquel extract for seborrheic dermatitis in vivo and in vitro. Methods: Seven patients with mild seborrheic dermatitis were enrolled in this study. PCR and culture were performed to identify subtypes of six Malassezia species (M. restricta, M. globosa, M. furfur, M. slooffiae, M. sympodialis, M. obtusa). Topical application of Rubus coreanus Miquel Extract was applied twice daily for 2 weeks. Clinical improvement and safety assessment were performed initially and 2weeks later. Minimum inhibitory concentration (MIC) was evaluated on Malassezia globosa comparing with ketoconazole and itraconazole. Sebum production was also checked prior the experiment and 2weeks later. Results: Five of seven patients showed improvement. No significant adverse effects were found during the clinical trial. Mild dryness was reported in 2 patients but they resolved spontaneously without any treatment. Rubus coreanus Miquel Extract didn't show antimicrobial effect to Malassezia globosa. However, Rubus coreanus Miquel Extract showed anti-inflammatory effect. Conclusion: In this study, we were verified that Rubus coreanus Miquel Extract can be applied for seborrheic dermatitis treatment. And this action mechanism is not related with antimicrobial effect.
Abstract
Background: Seborrheic dermatitis is chronic relapsing inflammatory skin disorder. Bokbunja (Rubus coreanus Miquel) is a wild berry to Rosaceae genus and also known to have an anti-inflammation effect. Objective: We were to determine the effect of Rubus coreanus Miquel extract for seborrheic dermatitis in vivo and in vitro. Methods: Seven patients with mild seborrheic dermatitis were enrolled in this study. PCR and culture were performed to identify subtypes of six Malassezia species (M. restricta, M. globosa, M. furfur, M. slooffiae, M. sympodialis, M. obtusa). Topical application of Rubus coreanus Miquel Extract was applied twice daily for 2 weeks. Clinical improvement and safety assessment were performed initially and 2weeks later. Minimum inhibitory concentration (MIC) was evaluated on Malassezia globosa comparing with ketoconazole and itraconazole. Sebum production was also checked prior the experiment and 2weeks later. Results: Five of seven patients showed improvement. No significant adverse effects were found during the clinical trial. Mild dryness was reported in 2 patients but they resolved spontaneously without any treatment. Rubus coreanus Miquel Extract didn't show antimicrobial effect to Malassezia globosa. However, Rubus coreanus Miquel Extract showed anti-inflammatory effect. Conclusion: In this study, we were verified that Rubus coreanus Miquel Extract can be applied for seborrheic dermatitis treatment. And this action mechanism is not related with antimicrobial effect.
참고문헌 (16)
- Korean dermatological association textbook editing board, "Dermatology. 5th edition", pp.185~187 (2008), Ryo Moon Gak
- Paek SH, "Clinical investigation and distribution of Pityrosporum in patients with seborrheic dermatitis of the scalp", Korean J Dermatol, 35, pp.22~32 (1997)
- Kim SJ, "Clinical effect of topical ketoconazole in seborrheic dermatitis of scalp", Korean J Dermatol, 30, pp.625~632 (1992)
- Bae GH, "The medicinal plants of Korea", pp.231~, Kyohak Publishing Co
- 김진경, "토종 복분자와 외래종 복분자 추출물의 항염증효과 비교", 한국식품과학회지, 39(3), pp.342~347 (2007), 한국식품과학회
- 신현재, "복분자 유용 성분의 연구과 그 응용", KSBB Journal, 21(6), pp.405~409 (2006), 한국생물공학회
- 김동하, "복분자 추출물 제제로 치료한 여드름 2예", 대한의진균학회지, 15(3), pp.140~145 (2010), 대한의진균학회1
- Mosmann T, "Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays", J Immunol Methods, 65, pp.55~63 (1983)
- Malassez L, "Note la champignon del la pilage", Arch physil Norm Pathol, 1, pp.203~210 (1874)
- 이택열, "복분자 미숙과 및 성숙과가 생쥐의 복강 Macrophages에 미치는 영향", 동의생리병리학회지, 17(4), pp.991~995 (2003), 대한동의병리학회
- 원경숙, "복분자가 생쥐의 특이적 면역반응에 미치는 영향", 동의생리병리학회지, 17(3), pp.656~661 (2003), 대한동의병리학회
- Kim KH, "Antioxidative activity of tannins from Rubus coreanum", Yakhak Hoeji, 44, pp.354~357 (2000)
- Lee JW, "Determination of total phenolic compounds from the fruit of Rubus coreanum and antioxidative activity", Korean Soc Food Scr Nutr, 29, pp.943~947 (2000)
- Elewski BE, "Safe and effective treatment of seborrheic dermatitis", Cutis, 83, pp.333~338 (2009)
- 전오도, "魚腥草 추출물의 항여드름 효과에 관한 연구", 대한약침학회지, 11(1), pp.119~125 (2008), 대한약침학회
- 유종엽, "상백피 추출물과 차나무 기름 제제가 여드름과 호기성 피부 상재균에 미치는 효과", 대한피부과학회지, 41(9), pp.1136~1141 (2003), 대한피부과학회