Fonsecaea monophora 에 의한 색소분아진균증 1예
Chromoblastomycosis Caused by Fonsecaea monophora
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초록
Chromoblastomycosis is a chronic subcutaneous mycotic infections caused by dermatiaceous fungi. Clinically, chromoblastomycosis presents frequently with erythematous or nodular plaque. In Korea, 10cases of chromoblastomycosis have been reported and Fonsecaea pedrosoi is the most common agent. A 61-year-old woman who was diagnosed as chronic inflammatory demyelinating polyneuropathy 3years ago, and had been treated with systemic corticosteroids and azathioprine, presented with pruritic,scaly erythematous plaques on the right forearm for 3 years. She had no history of trauma. Histologicalexamination showed pseudoepitheliomatous hyperplasia, mixed granulomatous inflammatory cellinfiltrate and multinucleated giant cells with sclerotic cells in the dermis. Tissue culture showed slowlygrowing, dark brown, velvety colony. DNA was extracted from the cultured colonies and the DNAsequence of the internal transcribed spacer (ITS) region of the clinical sample was matched for that ofFonsecaea monophora. The patient was treated with local heat therapy and topical terbinafine application.
Abstract
Chromoblastomycosis is a chronic subcutaneous mycotic infections caused by dermatiaceous fungi. Clinically, chromoblastomycosis presents frequently with erythematous or nodular plaque. In Korea, 10cases of chromoblastomycosis have been reported and Fonsecaea pedrosoi is the most common agent. A 61-year-old woman who was diagnosed as chronic inflammatory demyelinating polyneuropathy 3years ago, and had been treated with systemic corticosteroids and azathioprine, presented with pruritic,scaly erythematous plaques on the right forearm for 3 years. She had no history of trauma. Histologicalexamination showed pseudoepitheliomatous hyperplasia, mixed granulomatous inflammatory cellinfiltrate and multinucleated giant cells with sclerotic cells in the dermis. Tissue culture showed slowlygrowing, dark brown, velvety colony. DNA was extracted from the cultured colonies and the DNAsequence of the internal transcribed spacer (ITS) region of the clinical sample was matched for that ofFonsecaea monophora. The patient was treated with local heat therapy and topical terbinafine application.
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