피부 프로토테카증 1예
A Case of Cutaneous Protothecosis
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초록
Protothecosis is a rare skin infection caused by pathogenic algae of the genus Prototheca, especiallyPrototheca wickerhamii. It is widely distributed throughout the natural world in tree, river, lake, sewage,soil, marsh, household waste, etc. A 79-year-old woman presented with ill-defined edematous anderythematous patches with various sized and shaped deep ulcers on both dorsal hands and left distalforearm for 1 month. The left forearm was initially injured by scratching due to pruritus and insidiouslyaggravated. Biopsy specimen revealed the characteristic morula-like sporangias containing multipleendospores in the dermis. The GMS and D-PAS stains highlighted the characteristic spores showingmultiple internal septations and some unicellular endospore. P. wickerhamii was isolated in culture andidentified by biochemical studies. Oral itraconazole 200 mg/day administration for 7 weeks resulted inmarked improvement of the skin lesion.
Abstract
Protothecosis is a rare skin infection caused by pathogenic algae of the genus Prototheca, especiallyPrototheca wickerhamii. It is widely distributed throughout the natural world in tree, river, lake, sewage,soil, marsh, household waste, etc. A 79-year-old woman presented with ill-defined edematous anderythematous patches with various sized and shaped deep ulcers on both dorsal hands and left distalforearm for 1 month. The left forearm was initially injured by scratching due to pruritus and insidiouslyaggravated. Biopsy specimen revealed the characteristic morula-like sporangias containing multipleendospores in the dermis. The GMS and D-PAS stains highlighted the characteristic spores showingmultiple internal septations and some unicellular endospore. P. wickerhamii was isolated in culture andidentified by biochemical studies. Oral itraconazole 200 mg/day administration for 7 weeks resulted inmarked improvement of the skin lesion.
참고문헌 (19)
- Boyd AS, "Cutaneous manifestations of prototheca infections", J Am Acad Dermatol, 32, pp.758~764 (1995)
- Tejada E, "Cutaneous erythematous nodular lesion in a crab fisherman", Protothecosis. Arch Dermatol, 130, pp.244~245 (1994)
- Zhang Q, "A case of cutaneous protothecosis mimics eczema", Mycopathologia, ~ (2014)
- Pore RS, "Prototheca ecology", Mycopathologia, 81, pp.49~62 (1983)
- Sheikh-Ahmad M, "Prototheca wickerhamii hand infection successfully treated by itraconazole and voriconazole", J Travel Med, 13, pp.321~323 (2006)
- Torres HA, "Protothecosis in patients with cancer: case series and literature review", Clin Microbiol Infect, 9, pp.786~792 (2003)
- Lass-Florl C, "Human protothecosis", Clin Microbiol Rev, 20, pp.230~242 (2007)
- Davies RR, "A case of human protothecosis", Trans R Soc Trop Med Hyg, 58, pp.448~451 (1964)
- Todd JR, "Protothecosis: report of a case with 20-year follow-up, and review of previously published cases", Med Mycol, 50, pp.673~689 (2012)
- Kwon-Chung KJ, "Phylogenetic spectrum of fungi that are pathogenic to humans", Clin Infect Dis, 19(Suppl 1), pp.S1~S7 (1994)
- Chao SC, "Cutaneous protothecosis:report of five cases", Br J Dermatol, 146, pp.688~693 (2002)
- Woolrich A, "Cutaneous protothecosis and AIDS", J Am Acad Dermatol, 31, pp.920~924 (1994)
- Kim ST, "Successful treatment with fluconazole of protothecosis developing at the site of an intralesional corticosteroid injection", Br J Dermatol, 135, pp.803~806 (1996)
- Pfaller AA, "Unusual fungal and pseudofungal infections of humans", J Clin Microbiol, 43, pp.1495~1504 (2005)
- Kim JA, "Two cases of cutaneous protothecosis: unique histopathological findings with crystal violet staining and the therapeutic effect of itraconazole", Ann Dermatol, 9, pp.201~207 (1997)
- Kantrow SM, "Protothecosis", Dermatol Clin, 21, pp.249~255 (2003)
- Zhang QQ, "Cutaneous protothecosis in patient with diabetes mellitus and review of published case reports", Mycopathologia, 173, pp.163~171 (2012)
- 석재연, "Human Cutaneous Protothecosis: Report of a Case and Literature Review", Journal of Pathology and Translational Medicine, 47(6), pp.575~578 (2013), 대한병리학회[DOI]
- 문형식, "피부 프로토테카증 1예", 대한의진균학회지, 12(2), pp.70~74 (2007), 대한의진균학회