Retrospective analysis of bone regeneration following recombinant human bone morphogenetic protein-2 application in medication-related osteonecrosis of the jaw patients
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
This retrospective study evaluated the efficacy of bone regeneration following decortication and sequestrectomy combined with the application of recombinant human bone morphogenetic protein-2/absorbable collagen sponge (rhBMP-2/ACS) in 45 patients with medication-related osteonecrosis of the jaw (MRONJ). Each patient received 0.25 g of rhBMP-2/ACS at the surgical site. Facial computed tomography scans were obtained immediately postoperatively and at a six-month follow-up to assess volumetric changes in the alveolar bone. The results indicated that rhBMP-2 significantly enhanced bone regeneration. Notably, the number of residual bone walls was the only significant factor influencing the regenerative outcome (B = 19.47, standard error = 3.05, t = 6.39, p < 0.001). Four-wall defects exhibited the highest regeneration rate (85.2%), and the mandibular posterior region was the most frequently involved site (60.5%). Complications such as surgical site disruption did not significantly impact the regenerative outcomes. These findings suggest that the concomitant use of rhBMP-2 with decortication and sequestrectomy promotes bone healing, reduces recovery time, and improves treatment predictability for patients with MRONJ.
Abstract
This retrospective study evaluated the efficacy of bone regeneration following decortication and sequestrectomy combined with the application of recombinant human bone morphogenetic protein-2/absorbable collagen sponge (rhBMP-2/ACS) in 45 patients with medication-related osteonecrosis of the jaw (MRONJ). Each patient received 0.25 g of rhBMP-2/ACS at the surgical site. Facial computed tomography scans were obtained immediately postoperatively and at a six-month follow-up to assess volumetric changes in the alveolar bone. The results indicated that rhBMP-2 significantly enhanced bone regeneration. Notably, the number of residual bone walls was the only significant factor influencing the regenerative outcome (B = 19.47, standard error = 3.05, t = 6.39, p < 0.001). Four-wall defects exhibited the highest regeneration rate (85.2%), and the mandibular posterior region was the most frequently involved site (60.5%). Complications such as surgical site disruption did not significantly impact the regenerative outcomes. These findings suggest that the concomitant use of rhBMP-2 with decortication and sequestrectomy promotes bone healing, reduces recovery time, and improves treatment predictability for patients with MRONJ.