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Cutaneous Infection by Fusarium solani in an Immunocompetent Patient

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초록

Fusarium species are widely distributed throughout the environment, and rarely cause infection in healthy individuals. Herein, we report a rare case of cutaneous infection by Fusarium solani in a healthy patient. A 64-year-old patient presented with a tender, erythematous, deep-seated nodule above the left ankle after an intralesional triamcinolone injection for lipoma was administered at a private clinic 1 month ago. Fungal hyphae were identified in subcutaneous tissue by skin biopsy using Gomori methenamine silver stain. Lactophenol cotton blue staining, fungal culturing, and 28S rRNA sequencing confirmed the presence of F. solani. After diagnosis, the patient was successfully treated with oral itraconazole.

Abstract

Fusarium species are widely distributed throughout the environment, and rarely cause infection in healthy individuals. Herein, we report a rare case of cutaneous infection by Fusarium solani in a healthy patient. A 64-year-old patient presented with a tender, erythematous, deep-seated nodule above the left ankle after an intralesional triamcinolone injection for lipoma was administered at a private clinic 1 month ago. Fungal hyphae were identified in subcutaneous tissue by skin biopsy using Gomori methenamine silver stain. Lactophenol cotton blue staining, fungal culturing, and 28S rRNA sequencing confirmed the presence of F. solani. After diagnosis, the patient was successfully treated with oral itraconazole.

참고문헌 (8)

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  2. Gupta AK, "Fusarium infections of the skin", Curr Opin Infect Dis, 13, pp.121~128 (2000)
  3. 김희정, "Cutaneous infection by Fusarium solani associated with Arteriosclerosis obliterans in an immunocompetent patient", Annals of Dermatology, 19(3) (2007), 대한피부과학회
  4. Herkert PF, "Molecular characterization and antifungal susceptibility of clinical Fusarium species from Brazil", Front Microbiol, 10, pp.737~ (2019)
  5. Nucci M, "Cutaneous infection by Fusarium species in healthy and immunocompromised hosts : implications for diagnosis and management", Clin Infect Dis, 35, pp.909~920 (2002)
  6. Taj-Aldeen SJ, "Reduced multidrug susceptibility profile is a common feature of opportunistic Fusarium species : Fusarium multi-drug resistant pattern", J Fungi, 3, pp.18~ (2017)
  7. Nakamura Y, "Deep cutaneous infection by Fusarium solani in a healthy child : successful treatment with local heat therapy", J Am Acad Dermatol, 56, pp.873~877 (2007)
  8. 이명훈, "Fusarium oxysporum 에 의한 피부감염증", 대한의진균학회지, 18(3), pp.70~75 (2013), 대한의진균학회[DOI]

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