Effect of premature rupture of membranes on preterm labor: a case-control study in Cilegon, Indonesia
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
OBJECTIVES: The global prevalence of preterm labor is approximately 11.1% of live births. However, preterm labor contributes to 75-80% of neonatal morbidity and mortality. The morbidity experienced by preterm infants may continue to influence their subsequent development, imposing physical, psychological, and economic burdens. Premature rupture of membranes (PROM) is a causal factor that may affect preterm birth. Previous studies have shown an association between PROM and preterm labor, but this association should be investigated in more diverse populations. Therefore, this study was conducted in Cilegon, Indonesia to determine the magnitude of the risk of preterm labor associated with PROM at Cilegon Hospital from July 2014 to December 2015. METHODS: This case-control study used data from patients’ medical records. The cases were all mothers who delivered at less than 37 weeks of gestation, while the control population comprised all mothers who delivered at greater or equal to 37 weeks. The data were analyzed using logistic regression. RESULTS: The bivariate analysis yielded an odds ratio (OR) of 2.97 (95% confidence interval [CI], 1.92 to 4.59) before controlling for covariates. The model derived through multiple regression analysis after controlling for education, history of preterm labor, and anemia resulted in an OR of 2.58 (95% CI, 1.68 to 3.98). CONCLUSIONS: Mothers who experience PROM during pregnancy were at a 2.58 times higher risk of preterm labor after controlling for education, history of preterm labor, and anemia.
Abstract
OBJECTIVES: The global prevalence of preterm labor is approximately 11.1% of live births. However, preterm labor contributes to 75-80% of neonatal morbidity and mortality. The morbidity experienced by preterm infants may continue to influence their subsequent development, imposing physical, psychological, and economic burdens. Premature rupture of membranes (PROM) is a causal factor that may affect preterm birth. Previous studies have shown an association between PROM and preterm labor, but this association should be investigated in more diverse populations. Therefore, this study was conducted in Cilegon, Indonesia to determine the magnitude of the risk of preterm labor associated with PROM at Cilegon Hospital from July 2014 to December 2015. METHODS: This case-control study used data from patients’ medical records. The cases were all mothers who delivered at less than 37 weeks of gestation, while the control population comprised all mothers who delivered at greater or equal to 37 weeks. The data were analyzed using logistic regression. RESULTS: The bivariate analysis yielded an odds ratio (OR) of 2.97 (95% confidence interval [CI], 1.92 to 4.59) before controlling for covariates. The model derived through multiple regression analysis after controlling for education, history of preterm labor, and anemia resulted in an OR of 2.58 (95% CI, 1.68 to 3.98). CONCLUSIONS: Mothers who experience PROM during pregnancy were at a 2.58 times higher risk of preterm labor after controlling for education, history of preterm labor, and anemia.
참고문헌 (16)
- "Born too soon: the global action report on preterm birth" (2012)[URL]
- American College of Obstetricians and Gynecologists, "ACOG practice bulletin no. 127: management of preterm labor", Obstet Gynecol, 119, pp.1308~1317 (2012)
- Blencowe H, "National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries : a systematic analysis and implications", Lancet, 379, pp.2162~2172 (2012)
- "Preterm labor and birth - frequently asked questions: labor, delivery, and postpartum care"[URL]
- Cunningham FG, "William obstetrics", pp.829~861 (2014), McGraw-Hill Education
- Kinney MV, "15 Million preterm births annually : what has changed this year", Reprod Health, 9, pp.28~ (2012)
- Beck S, "The worldwide incidence of preterm birth : a systematic review of maternal mortality and morbidity", Bull World Health Organ, 88, pp.31~38 (2010)
- Rao CR, "A case-control study on risk factors for preterm deliveries in a secondary care hospital, southern India", ISRN Obstet Gynecol, 2014, pp.935982~ (2014)
- Sungkar A, "High preterm birth at Cipto Mangunkusumo Hospital as a national referral hospital in Indonesia", Med J Indones, 26, pp.198~203 (2017)
- Di Renzo GC, "Guidelines for the management of spontaneous preterm labor", J Perinat Med, 34, pp.359~366 (2006)
- Moutquin JM, "Classification and heterogeneity of preterm birth", BJOG, 110(Suppl 20), pp.30~33 (2003)
- Derakhshi B, "Risk factor of preterm labor in the west of iran : a case-control study", Iran J Public Health, 43, pp.499~506 (2014)
- "APEC guidelines premature rupture of membranes" (2013)[URL]
- Mercer BM, "Maternal–fetal medicine: principles and practice", pp.599~608 (2009), Saunders Elsevier
- Dale PO, "Duration of the latency period in preterm premature rupture of the membranes. Maternal and neonatal consequences of expectant management", Eur J Obstet Gynecol Reprod Biol, 30, pp.257~262 (1989)
- Medina TM, "Preterm premature rupture of membranes : diagnosis and management", Am Fam Physician, 73, pp.659~664 (2006)