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Gender-specific associations among neck circumference, the rs9939609 FTO gene polymorphism, and the 14-year risk of metabolic syndrome in the Korean adult population

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OBJECTIVES: Limited data exist on the relation between neck circumference (NC) and the risk of developing metabolic syndrome (MS). This study investigated gender-specific associations between NC and the 14-year risk of MS and explored the impact of the FTO rs9939609 polymorphism on these associations.METHODS: This population-based prospective cohort study involved 2,666 participants (1,301 men and 1,365 women), who were free of MS at baseline (2005-2006). Incident MS cases, defined by the presence of 3 or more criteria regarding blood pressure and blood levels of glucose, triglycerides, and high-density lipoprotein cholesterol, were identified through biennial examinations until 2020. NC measurements taken at baseline and between 2013 and 2014 were analyzed using Cox proportional hazard regression to determine gender-specific associations with MS risk.RESULTS: Controlling for potential confounders such as waist circumference (WC), significant associations were observed in both genders. Individuals in the highest NC quartile exhibited more than a 2-fold higher MS risk than those in the lowest quartile; with hazard ratios of 2.37 (95% confidence interval [CI], 1.74 to 3.22) for men and 2.65 (95% CI, 1.89 to 3.72) for women (p for trend <0.001). No significant interaction was found between the FTO polymorphism and NC. In diagnostic test analyses, NC and WC demonstrated comparable area under the curve values in both genders.CONCLUSIONS: The findings suggest that NC is as effective as WC for predicting the incidence of MS.

Abstract

OBJECTIVES: Limited data exist on the relation between neck circumference (NC) and the risk of developing metabolic syndrome (MS). This study investigated gender-specific associations between NC and the 14-year risk of MS and explored the impact of the FTO rs9939609 polymorphism on these associations.METHODS: This population-based prospective cohort study involved 2,666 participants (1,301 men and 1,365 women), who were free of MS at baseline (2005-2006). Incident MS cases, defined by the presence of 3 or more criteria regarding blood pressure and blood levels of glucose, triglycerides, and high-density lipoprotein cholesterol, were identified through biennial examinations until 2020. NC measurements taken at baseline and between 2013 and 2014 were analyzed using Cox proportional hazard regression to determine gender-specific associations with MS risk.RESULTS: Controlling for potential confounders such as waist circumference (WC), significant associations were observed in both genders. Individuals in the highest NC quartile exhibited more than a 2-fold higher MS risk than those in the lowest quartile; with hazard ratios of 2.37 (95% confidence interval [CI], 1.74 to 3.22) for men and 2.65 (95% CI, 1.89 to 3.72) for women (p for trend <0.001). No significant interaction was found between the FTO polymorphism and NC. In diagnostic test analyses, NC and WC demonstrated comparable area under the curve values in both genders.CONCLUSIONS: The findings suggest that NC is as effective as WC for predicting the incidence of MS.

참고문헌 (30)

  1. Agarwal SK, "Waist circumference measurement by site, posture, respiratory phase, and meal time : implications for methodology", Obesity(Silver Spring), 17, pp.1056~1061 (2009)[DOI]
  2. Namazi N, "The association of neck circumference with risk of metabolic syndrome and its components in adults : a systematic review and meta-analysis", Nutr Metab Cardiovasc Dis, 28, pp.657~674 (2018)[DOI]
  3. Zanuncio VV, "Neck circumference and the burden of metabolic syndrome disease : a population-based sample", J Public Health(Oxf), 44, pp.753~760 (2022)[DOI]
  4. Raimi TH, "Neck circumference cut-off for obesity and metabolic syndrome in Nigeria", Ethn Dis, 31, pp.501~508 (2021)[DOI]
  5. Ebrahimi H, "Neck circumference and metabolic syndrome : a cross-sectional population-based study", Prim Care Diabetes, 15, pp.582~587 (2021)[DOI]
  6. Kim KY, "Neck circumference as a predictor of metabolic syndrome in Koreans : a cross-sectional study", Nutrients, 13, pp.3029~ (2021)[DOI]
  7. Lin S, "Utility of neck circumference for identifying metabolic syndrome by different definitions in Chinese subjects over 50 years old : a community-based study", J Diabetes Res, 2018, pp.3708939~ (2018)[DOI]
  8. Alzeidan R, "Performance of neck circumference to predict obesity and metabolic syndrome among adult Saudis : a cross-sectional study", BMC Obes, 6, pp.13~ (2019)[DOI]
  9. Ben-Noun LL, "Relationship between changes in neck circumference and cardiovascular risk factors", Exp Clin Cardiol, 11, pp.14~20 (2006)
  10. Dixon JB, "Neck circumference a good predictor of raised insulin and free androgen index in obese premenopausal women : changes with weight loss", Clin Endocrinol(Oxf), 57, pp.769~778 (2002)[DOI]
  11. Dina C, "Variation in FTO contributes to childhood obesity and severe adult obesity", Nat Genet, 39, pp.724~726 (2007)[DOI]
  12. Pausova Z, "A common variant of the FTO gene is associated with not only increased adiposity but also elevated blood pressure in French Canadians", Circ Cardiovasc Genet, 2, pp.260~269 (2009)[DOI]
  13. Legry V, "Effect of an FTO polymorphism on fat mass, obesity, and type 2 diabetes mellitus in the French MONICA Study", Metabolism, 58, pp.971~975 (2009)[DOI]
  14. Al-Attar SA, "Association between the FTO rs9939609 polymorphism and the metabolic syndrome in a non-Caucasian multi-ethnic sample", Cardiovasc Diabetol, 7, pp.5~ (2008)[DOI]
  15. Baik I, "Interactions between the FTO rs9939609 polymorphism, body mass index, and lifestyle-related factors on metabolic syndrome risk", Nutr Res Pract, 6, pp.78~85 (2012)[DOI]
  16. Sjögren M, "The search for putative unifying genetic factors for components of the metabolic syndrome", Diabetologia, 51, pp.2242~2251 (2008)[DOI]
  17. Merra G, "FTO rs9939609 influence on adipose tissue localization in the Italian population", Eur Rev Med Pharmacol Sci, 24, pp.3223~3235 (2020)[DOI]
  18. Baik I, "Prospective study of alcohol consumption and metabolic syndrome", Am J Clin Nutr, 87, pp.1455~1463 (2008)[DOI]
  19. Baik I, "Genome-wide association studies identify genetic loci related to alcohol consumption in Korean men", Am J Clin Nutr, 93, pp.809~816 (2011)[DOI]
  20. Alberti KG, "Metabolic syndrome--a new world-wide definition. A consensus statement from the International Diabetes Federation", Diabet Med, 23, pp.469~480 (2006)[DOI]
  21. Cho YS, "A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits", Nat Genet, 41, pp.527~534 (2009)[DOI]
  22. Yan Q, "Neck circumference is a valuable tool for identifying metabolic syndrome and obesity in Chinese elder subjects : a community-based study", Diabetes Metab Res Rev, 30, pp.69~76 (2014)[DOI]
  23. Hingorjo MR, "Neck circumference : a supplemental tool for the diagnosis of metabolic syndrome", J Pak Med Assoc, 66, pp.1221~1226 (2016)
  24. An J, "The relationship between neck circumference and cardiovascular risk factors including metabolic syndrome in Korean adults over 40 years of age : the Korean National Health and Nutrition Examination Survey, 2019", Korean J Fam Pract, 12, pp.193~200 (2022)[DOI]
  25. Gerken T, "The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase", Science, 318, pp.1469~1472 (2007)[DOI]
  26. Church C, "Overexpression of FTO leads to increased food intake and results in obesity", Nat Genet, 42, pp.1086~1092 (2010)[DOI]
  27. Wåhlén K, "The common rs9939609 gene variant of the fat mass-and obesity-associated gene FTO is related to fat cell lipolysis", J Lipid Res, 49, pp.607~611 (2008)[DOI]
  28. Sun K, "Active smoking and risk of metabolic syndrome : a meta-analysis of prospective studies", PLoS One, 7, pp.e47791~ (2012)[DOI]
  29. Sun K, "Alcohol consumption and risk of metabolic syndrome : a meta-analysis of prospective studies", Clin Nutr, 33, pp.596~602 (2014)[DOI]
  30. Alavi SS, "Metabolic syndrome : a common problem among office workers", Int J Occup Environ Med, 6, pp.34~40 (2015)[DOI]

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