Sex-specific associations between dietary legume subtypes and type 2 diabetes in a prospective cohort study
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
OBJECTIVES: Dietary soy, known for its high phytoestrogen content, has been suggested to exhibit a sex-specific association with type 2 diabetes. However, evidence regarding the sex-specific associations of different legume subtypes with type 2 diabetes remains scarce. We aimed to evaluate whether habitual consumption of soy and non-soy legumes (beans and peanuts) was prospectively and sex-specifically associated with the risk of type 2 diabetes incidence, taking into considering significant sex-specific genetic factors beyond legume consumption.METHODS: A total of 16,666 participants (96,945 person-years) were followed and 945 incident cases were observed. Cumulative intake of legume subtypes was calculated using a food frequency questionnaire administered at baseline and during the revisit surveys.RESULTS: Non-soy legumes are inversely associated with type 2 diabetes in both men and women. Dietary soy intake, however, demonstrated a unilaterally interacting sex-specific association with type 2 diabetes risk (pinteraction for sex=0.017). Specifically, there was a significant inverse association with type 2 diabetes risk in women (incidence rate ratio, 0.66; 95% confidence interval, 0.48 to 0.80; ptrend=0.007), but no such association was observed in men. This sex-specific association persisted and even appeared antagonistic in minor allele carriers of 2 novel single nucleotide polymorphisms, rs10196939 (LRRTM4) and rs11750158 (near GFPT2) (pinteraction for sex=0.001 and 0.011, respectively).CONCLUSIONS: Habitual consumption of legumes shows protective impacts against type 2 diabetes, although these benefits vary by sex. Non-soy legumes provide health advantages for both men and women, whereas soy consumption seems to be beneficial exclusively for women.
Abstract
OBJECTIVES: Dietary soy, known for its high phytoestrogen content, has been suggested to exhibit a sex-specific association with type 2 diabetes. However, evidence regarding the sex-specific associations of different legume subtypes with type 2 diabetes remains scarce. We aimed to evaluate whether habitual consumption of soy and non-soy legumes (beans and peanuts) was prospectively and sex-specifically associated with the risk of type 2 diabetes incidence, taking into considering significant sex-specific genetic factors beyond legume consumption.METHODS: A total of 16,666 participants (96,945 person-years) were followed and 945 incident cases were observed. Cumulative intake of legume subtypes was calculated using a food frequency questionnaire administered at baseline and during the revisit surveys.RESULTS: Non-soy legumes are inversely associated with type 2 diabetes in both men and women. Dietary soy intake, however, demonstrated a unilaterally interacting sex-specific association with type 2 diabetes risk (pinteraction for sex=0.017). Specifically, there was a significant inverse association with type 2 diabetes risk in women (incidence rate ratio, 0.66; 95% confidence interval, 0.48 to 0.80; ptrend=0.007), but no such association was observed in men. This sex-specific association persisted and even appeared antagonistic in minor allele carriers of 2 novel single nucleotide polymorphisms, rs10196939 (LRRTM4) and rs11750158 (near GFPT2) (pinteraction for sex=0.001 and 0.011, respectively).CONCLUSIONS: Habitual consumption of legumes shows protective impacts against type 2 diabetes, although these benefits vary by sex. Non-soy legumes provide health advantages for both men and women, whereas soy consumption seems to be beneficial exclusively for women.
참고문헌 (50)
- Becerra-Tomás N, "Legume consumption and cardiometabolic health", Adv Nutr, 10(Suppl_4), pp.S437~S450 (2019)[DOI]
- Moreno-Valdespino CA, "Bioactive proteins and phytochemicals from legumes : mechanisms of action preventing obesity and type-2 diabetes", Food Res Int, 130, pp.108905~ (2020)[DOI]
- Tang J, "Legume and soy intake and risk of type 2 diabetes : a systematic review and meta-analysis of prospective cohort studies", Am J Clin Nutr, 111, pp.677~688 (2020)[DOI]
- Hemler EC, "Plant-based diets for cardiovascular disease prevention : all plant foods are not created equal", Curr Atheroscler Rep, 21, pp.18~ (2019)[DOI]
- Kokubo Y, "Association of dietary intake of soy, beans, and isoflavones with risk of cerebral and myocardial infarctions in Japanese populations : the Japan Public Health Center-based(JPHC)study cohort I", Circulation, 116, pp.2553~2562 (2007)[DOI]
- Pan A, "Soy protein intake has sex-specific effects on the risk of metabolic syndrome in middle-aged and elderly Chinese", J Nutr, 138, pp.2413~2421 (2008)[DOI]
- Nanri A, "Soy product and isoflavone intakes are associated with a lower risk of type 2 diabetes in overweight Japanese women", J Nutr, 140, pp.580~586 (2010)[DOI]
- Yu D, "Association of soy food intake with risk and biomarkers of coronary heart disease in Chinese men", Int J Cardiol, 172, pp.e285~e287 (2014)[DOI]
- Talaei M, "Dietary soy intake is not associated with risk of cardiovascular disease mortality in Singapore Chinese adults", J Nutr, 144, pp.921~928 (2014)[DOI]
- Agrawal S, "Association between legume intake and self-reported diabetes among adult men and women in India", BMC Public Health, 13, pp.706~ (2013)[DOI]
- Konishi K, "Dietary soy intake is inversely associated with risk of type 2 diabetes in Japanese women but not in men", J Nutr, 149, pp.1208~1214 (2019)[DOI]
- Woo HW, "Sex-specific associations of habitual intake of soy protein and isoflavones with risk of type 2 diabetes", Clin Nutr, 40, pp.127~136 (2021)[DOI]
- Kautzky-Willer A, "Sex and gender differences in risk, pathophysiology and complications of type 2 diabetes mellitus", Endocr Rev, 37, pp.278~316 (2016)[DOI]
- Lagou V, "Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability", Nat Commun, 12, pp.24~ (2021)[DOI]
- Kim Y, "Cohort profile : the Korean Genome and Epidemiology Study(KoGES)consortium", Int J Epidemiol, 46, pp.e20~ (2017)[DOI]
- Ahn Y, "Validation and reproducibility of food frequency questionnaire for Korean genome epidemiologic study", Eur J Clin Nutr, 61, pp.1435~1441 (2007)[DOI]
- Korean Nutrition Society, "Food values" (2009), Korean Nutrition Society
- Hu FB, "Dietary fat and coronary heart disease : a comparison of approaches for adjusting for total energy intake and modeling repeated dietary measurements", Am J Epidemiol, 149, pp.531~540 (1999)[DOI]
- American Diabetes Association, "2. Classification and diagnosis of diabetes : standards of medical care in diabetes-2018", Diabetes Care, 41(Suppl 1), pp.S13~S27 (2018)[DOI]
- Moon S, "The Korea Biobank Array : design and identification of coding variants associated with blood biochemical traits", Sci Rep, 9, pp.1382~ (2019)[DOI]
- Howie BN, "A flexible and accurate genotype imputation method for the next generation of genome-wide association studies", PLoS Genet, 5, pp.e1000529~ (2009)[DOI]
- Teare MD, "Genetic epidemiology", pp.89~103 (2011), Springer
- Woodward M, "Epidemiology: study design and data analysis", pp.176~177 (2013), CRC Press
- Callas PW, "Empirical comparisons of proportional hazards, poisson, and logistic regression modeling of occupational cohort data", Am J Ind Med, 33, pp.33~47 (1998)[DOI]
- Zou G, "A modified poisson regression approach to prospective studies with binary data", Am J Epidemiol, 159, pp.702~706 (2004)[DOI]
- Kim S, "The Diet Quality Index-International(DQI-I)provides an effective tool for cross-national comparison of diet quality as illustrated by China and the United States", J Nutr, 133, pp.3476~3484 (2003)[DOI]
- Kraft P, "Exploiting gene-environment interaction to detect genetic associations", Hum Hered, 63, pp.111~119 (2007)[DOI]
- Purcell S, "PLINK : a tool set for whole-genome association and population-based linkage analyses", Am J Hum Genet, 81, pp.559~575 (2007)[DOI]
- Hong SM, "A prospective association between dietary folate intake and type 2 diabetes risk among Korean adults aged 40 years or older : the Korean Multi-Rural Communities Cohort(MRCohort)Study", Br J Nutr, 118, pp.1078~1088 (2017)[DOI]
- Oh JM, "Dietary total, animal, vegetable calcium and type 2 diabetes incidence among Korean adults : the Korean Multi-Rural Communities Cohort(MRCohort)", Nutr Metab Cardiovasc Dis, 27, pp.1152~1164 (2017)[DOI]
- Kim SY, "Association of dietary glycaemic index, glycaemic load, and total carbohydrates with incidence of type-2 diabetes in adults aged ≥40 years : the Multi-Rural Communities Cohort(MRCohort)", Diabetes Res Clin Pract, 160, pp.108007~ (2020)[DOI]
- Mueller NT, "Soy intake and risk of type 2 diabetes in Chinese Singaporeans", Eur J Nutr, 51, pp.1033~1040 (2012)[DOI]
- Manach C, "Polyphenols : food sources and bioavailability", Am J Clin Nutr, 79, pp.727~747 (2004)[DOI]
- Ding M, "Consumption of soy foods and isoflavones and risk of type 2 diabetes : a pooled analysis of three US cohorts", Eur J Clin Nutr, 70, pp.1381~1387 (2016)[DOI]
- quinoline, "Mutagenesis", 1994, 101~106, 10.1093[DOI]
- Adlercreutz H, "Inhibition of human aromatase by mammalian lignans and isoflavonoid phytoestrogens", J Steroid Biochem Mol Biol, 44, pp.147~153 (1993)[DOI]
- Goodin S, "Clinical and biological activity of soy protein powder supplementation in healthy male volunteers", Cancer Epidemiol Biomarkers Prev, 16, pp.829~833 (2007)[DOI]
- Nagata C, "Inverse association of soy product intake with serum androgen and estrogen concentrations in Japanese men", Nutr Cancer, 36, pp.14~18 (2000)[DOI]
- Gardner-Thorpe D, "Dietary supplements of soya flour lower serum testosterone concentrations and improve markers of oxidative stress in men", Eur J Clin Nutr, 57, pp.100~106 (2003)[DOI]
- Hamilton-Reeves JM, "Clinical studies show no effects of soy protein or isoflavones on reproductive hormones in men : results of a meta-analysis", Fertil Steril, 94, pp.997~1007 (2010)[DOI]
- Habito RC, "Effects of replacing meat with soyabean in the diet on sex hormone concentrations in healthy adult males", Br J Nutr, 84, pp.557~563 (2000)[DOI]
- Duncan AM, "Modest hormonal effects of soy isoflavones in postmenopausal women", J Clin Endocrinol Metab, 84, pp.3479~3484 (1999)[DOI]
- Ding EL, "Sex differences of endogenous sex hormones and risk of type 2 diabetes : a systematic review and meta-analysis", JAMA, 295, pp.1288~1299 (2006)[DOI]
- Laurén J, "A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system", Genomics, 81, pp.411~421 (2003)[DOI]
- McCarthy MM, "How it’s made : organisational effects of hormones on the developing brain", J Neuroendocrinol, 22, pp.736~742 (2010)[DOI]
- Reichman RD, "Targeted sequencing of the LRRTM gene family in suicide attempters with bipolar disorder", Am J Med Genet B Neuropsychiatr Genet, 183, pp.128~139 (2020)[DOI]
- Marshall S, "Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance", J Biol Chem, 266, pp.4706~4712 (1991)[DOI]
- Zhang H, "Common variants in glutamine : fructose-6-phosphate amidotransferase 2(GFPT2)gene are associated with type 2 diabetes, diabetic nephropathy, and increased GFPT2 mRNA levels", J Clin Endocrinol Metab, 89, pp.748~755 (2004)[DOI]
- Ley SH, "Prevention and management of type 2 diabetes : dietary components and nutritional strategies", Lancet, 383, pp.1999~2007 (2014)[DOI]
- Bingham M, "Gut metabolism and cardioprotective effects of dietary isoflavones", Curr Top Nutraceutical Res, 1, pp.31~48 (2003)
