Is Electrocochleography Still Helpful in Early Diagnosis of Meniere Disease?
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Background and Objectives: Despite the extensive research for the Meniere’s disease(MD), it’s pathophysiology still remains uncertain and questionable among scientists. Clinicalsymptoms and audiometric tests form the basis for the diagnosis. Nevertheless the differentialdiagnosis can be extremely challenging, due to subjective and not specific results. Incorrectdiagnosis is most likely and for this reason there is a great demand for objective and reliabletests. Subjects and Methods: The presence of endolymphatic hydrops is necessarycondition but non enough for the diagnosis. In this study we analyze retrospectively the summatingpotentials (SP)/action protentials (AP) ratio from peritympanic electrocochleography in34 patients,divided in two groups (13 patients classified as defined MD and 21 patients classifiedas probable MD). The purpose was to identify the utility of the exam so to be able toachieve an early defined diagnosis. Furthermore our intention was to obtain an objectivetest, besides the clinical criteria currently in use for the diagnosis and the classification of theMD. Results: The analysis of the SP/AP results shows high predictability for the MD (positivein six out of seven cases with a sensitivity greater than 80%). Conclusions: Our study demonstratesa satisfactory sensibility percentage in recurrent defined MD presentation (>80%). Early identification of MD can lead to an early treatment and control of the progression of thedisease. Furthermore it could be a valuable instrument for the follow up and evaluation of thepatients classified as probable MD in accordance with the criteria of the American Academyof Otolaryngology-Head and Neck Surgery (1995).
Abstract
Background and Objectives: Despite the extensive research for the Meniere’s disease(MD), it’s pathophysiology still remains uncertain and questionable among scientists. Clinicalsymptoms and audiometric tests form the basis for the diagnosis. Nevertheless the differentialdiagnosis can be extremely challenging, due to subjective and not specific results. Incorrectdiagnosis is most likely and for this reason there is a great demand for objective and reliabletests. Subjects and Methods: The presence of endolymphatic hydrops is necessarycondition but non enough for the diagnosis. In this study we analyze retrospectively the summatingpotentials (SP)/action protentials (AP) ratio from peritympanic electrocochleography in34 patients,divided in two groups (13 patients classified as defined MD and 21 patients classifiedas probable MD). The purpose was to identify the utility of the exam so to be able toachieve an early defined diagnosis. Furthermore our intention was to obtain an objectivetest, besides the clinical criteria currently in use for the diagnosis and the classification of theMD. Results: The analysis of the SP/AP results shows high predictability for the MD (positivein six out of seven cases with a sensitivity greater than 80%). Conclusions: Our study demonstratesa satisfactory sensibility percentage in recurrent defined MD presentation (>80%). Early identification of MD can lead to an early treatment and control of the progression of thedisease. Furthermore it could be a valuable instrument for the follow up and evaluation of thepatients classified as probable MD in accordance with the criteria of the American Academyof Otolaryngology-Head and Neck Surgery (1995).
참고문헌 (18)
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