Neuropharmacological Targets for Drug Action in Vestibular Sensory Pathways
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The use of pharmacological agents is often the preferred approach to the management ofvestibular dysfunction. In the vestibular sensory pathways, the sensory neuroepithelia arethought to be influenced by a diverse number of neuroactive substances that may act toenhance or inhibit the effect of the primary neurotransmitters [i.e., glutamate (Glu) and acetylcholine(ACh)] or alter their patterns of release. This review summarizes various efforts toidentify drug targets including neurotransmitter and neuromodulator receptors in the vestibularsensory pathways. Identifying these receptor targets provides a strategic basis to usespecific pharmacological tools to modify receptor function in the treatment and managementof debilitating balance disorders. A review of the literature reveals that most investigationsof the neuropharmacology of peripheral vestibular function have been performed usingin vitro or ex vivo animal preparations rather than studying drug action on the normalintact vestibular system in situ. Such noninvasive approaches could aid the development ofmore accurate and effective intervention strategies for the treatment of dizziness and vertigo. The current review explores the major neuropharmacological targets for drug action inthe vestibular system.
Abstract
The use of pharmacological agents is often the preferred approach to the management ofvestibular dysfunction. In the vestibular sensory pathways, the sensory neuroepithelia arethought to be influenced by a diverse number of neuroactive substances that may act toenhance or inhibit the effect of the primary neurotransmitters [i.e., glutamate (Glu) and acetylcholine(ACh)] or alter their patterns of release. This review summarizes various efforts toidentify drug targets including neurotransmitter and neuromodulator receptors in the vestibularsensory pathways. Identifying these receptor targets provides a strategic basis to usespecific pharmacological tools to modify receptor function in the treatment and managementof debilitating balance disorders. A review of the literature reveals that most investigationsof the neuropharmacology of peripheral vestibular function have been performed usingin vitro or ex vivo animal preparations rather than studying drug action on the normalintact vestibular system in situ. Such noninvasive approaches could aid the development ofmore accurate and effective intervention strategies for the treatment of dizziness and vertigo. The current review explores the major neuropharmacological targets for drug action inthe vestibular system.
참고문헌 (44)
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