Ototoxicity: A Challenge in Diagnosis and Treatment
2
조회
0
다운로드
3
인용
0
참고문헌
키워드
초록
Ototoxicity is the pharmacological adverse reaction affecting the inner ear or auditory nerve,characterized by cochlear or vestibular dysfunction. The panorama of drug-induced hearingloss has widened over last few decades. Although ototoxic medications play an imperativerole in modern medicine, they have the capacity to cause harm and lead to significant morbidity. Evidence has shown early detection of toxicity through prospective ototoxicity monitoringallows for consideration of treatment modifications to minimize or prevent permanenthearing loss and balance impairment. Although many ototoxicity monitoring protocols exist,their practicality is questionable due to several factors. Even though the existing protocolshave proven to be effective, certain lacunae in practice have been encountered due to discrepanciesamong recommended protocols. Implementation of these protocols is mostlyheld back due to the incapacitated status of the patient. The choice of early ototoxicity identificationtechniques is still debatable due to variables such as high degree of sensitivity,specificity and reliability, less time consumption and less labour-intensive to the patient. Hence, the diagnosis and effective treatment of ototoxicity is challenging, even today. A stringentprotocol with more practicality encompassing all elements aimed at profiling the effectsof ototoxicity is greatly needed. This review describes an efficient application of ototoxicitymonitoring and treatment protocol as an attempt to reduce the challenges in diagnosis andmanagement of ototoxicity.
Abstract
Ototoxicity is the pharmacological adverse reaction affecting the inner ear or auditory nerve,characterized by cochlear or vestibular dysfunction. The panorama of drug-induced hearingloss has widened over last few decades. Although ototoxic medications play an imperativerole in modern medicine, they have the capacity to cause harm and lead to significant morbidity. Evidence has shown early detection of toxicity through prospective ototoxicity monitoringallows for consideration of treatment modifications to minimize or prevent permanenthearing loss and balance impairment. Although many ototoxicity monitoring protocols exist,their practicality is questionable due to several factors. Even though the existing protocolshave proven to be effective, certain lacunae in practice have been encountered due to discrepanciesamong recommended protocols. Implementation of these protocols is mostlyheld back due to the incapacitated status of the patient. The choice of early ototoxicity identificationtechniques is still debatable due to variables such as high degree of sensitivity,specificity and reliability, less time consumption and less labour-intensive to the patient. Hence, the diagnosis and effective treatment of ototoxicity is challenging, even today. A stringentprotocol with more practicality encompassing all elements aimed at profiling the effectsof ototoxicity is greatly needed. This review describes an efficient application of ototoxicitymonitoring and treatment protocol as an attempt to reduce the challenges in diagnosis andmanagement of ototoxicity.
참고문헌 (67)
- Naunton RF, "The ototoxicity of Kanamycin sulfate in the presence of compromised renal function", AMA Arch Otolaryngol, 69, pp.398~399 (1959)[DOI]
- Arslan E, "Global problem of drug-induced hearing loss", Ann N Y Acad Sci, 884, pp.1~14 (1999)[DOI]
- Cianfrone G, "Pharmacological drugs inducing ototoxicity, vestibular symptoms and tinnitus: a reasoned and updated guide", Eur Rev Med Pharmacol Sci, 15, pp.601~636 (2011)
- Knight KR, "Ototoxicity in children receiving platinum chemotherapy: underestimating a commonly occurring toxicity that may influence academic and social development", J Clin Oncol, 23, pp.8588~8596 (2005)[DOI]
- Konrad-Martin D, "Audiological monitoring of patients receiving ototoxic drugs", Perspect Hear Hear Disord Res Res Diagn, 9, pp.17~22 (2005)[DOI]
- Coradini PP, "Ototoxicity from cisplatin therapy in childhood cancer", J Pediatr Hematol Oncol, 29, pp.355~360 (2007)[DOI]
- McKeage MJ, "Comparative adverse effect profiles of platinum drugs", Drug Saf, 13, pp.228~244 (1995)[DOI]
- Bisht M, "Ototoxicity: the hidden menace", Indian J Otolaryngol Head Neck Surg, 63, pp.255~259 (2011)[DOI]
- Rybak LP, "Ototoxicity of loop diuretics", Otolaryngol Clin North Am, 26, pp.829~844 (1993)
- Peters U, "Glutathione S-transferase genetic polymorphisms and individual sensitivity to the ototoxic effect of cisplatin", Anticancer Drugs, 11, pp.639~643 (2000)[DOI]
- Oldenburg J, "Cisplatin-induced long-term hearing impairment is associated with specific glutathione s-transferase genotypes in testicular cancer survivors", J Clin Oncol, 25, pp.708~714 (2007)[DOI]
- Riedemann L, "Megalin genetic polymorphisms and individual sensitivity to the ototoxic effect of cisplatin", Pharmacogenomics J, 8, pp.23~28 (2008)[DOI]
- Ross CJ, "Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy", Nat Genet, 41, pp.1345~1349 (2009)[DOI]
- Palodetto B, "Influence of glutathione s-transferase on the ototoxicity caused by aminoglycosides", Braz J Otorhinolaryngol, 76, pp.306~309 (2010)[DOI]
- Rednam S, "Glutathione S-transferase P1 single nucleotide polymorphism predicts permanent ototoxicity in children with medulloblastoma", Pediatr Blood Cancer, 60, pp.593~598 (2013)[DOI]
- Choeyprasert W, "Cisplatin-induced ototoxicity in pediatric solid tumors: the role of glutathione S-transferases and megalin genetic polymorphisms", J Pediatr Hematol Oncol, 35, pp.e138~e143 (2013)[DOI]
- Pussegoda K, "Replication of TPMT and ABCC3 genetic variants highly associated with cisplatin-induced hearing loss in children", Clin Pharmacol Ther, 94, pp.243~251 (2013)[DOI]
- Yang JJ, "The role of inherited TPMT and COMT genetic variation in cisplatin-induced ototoxicity in children with cancer", Clin Pharmacol Ther, 94, pp.252~259 (2013)[DOI]
- Hagleitner MM, "Influence of genetic variants in TPMT and COMT associated with cisplatin induced hearing loss in patients with cancer: two new cohorts and a meta-analysis reveal significant heterogeneity between cohorts", PLoS One, 9, pp.e115869~ (2014)[DOI]
- Qian Y, "Interaction of aminoglycosides with human mitochondrial 12S rRNA carrying the deafness-associated mutation", Antimicrob Agents Chemother, 53, pp.4612~4618 (2009)[DOI]
- Xu H, "Common variants in ACYP2 influence susceptibility to cisplatininduced hearing loss", Nat Genet, 47, pp.263~266 (2015)[DOI]
- Brown AL, "SOD2 genetic variant associated with treatment-related ototoxicity in cisplatin-treated pediatric medulloblastoma", Cancer Med, 4, pp.1679~1686 (2015)[DOI]
- American Speech-Language-Hearing Association, "Guidelines for the audiologic management of individuals receiving cochleotoxic drug therapy", ASHA, 36(Suppl 12), pp.11~19 (1994)
- Fausti SA, "High-frequency audiometric monitoring strategies for early detection of ototoxicity", Ear Hear, 15, pp.232~239 (1994)
- "American Academy of Audiology position statement and clinical practice guidelines: ototoxicity monitoring"[URL]
- Wilkinson JD, "Audit of hearing surveillance in UK paediatric cystic fibrosis units", J Cyst Fibros, 8(Suppl 2), pp.S107~ (2009)
- Van Meter DJ, "A survey of oncedaily dosage tobramycin therapy in patients with cystic fibrosis", Pediatr Pulmonol, 44, pp.325~329 (2009)[DOI]
- Al-Malky G, "An analysis of ototoxicity in children: audiological detection, clinical practice and genetic susceptibility", pp.2014
- Knight KR, "Early changes in auditory function as a result of platinum chemotherapy: use of extended high-frequency audiometry and evoked distortion product otoacoustic emissions", J Clin Oncol, 25, pp.1190~1195 (2007)[DOI]
- Reavis KM, "Factors affecting sensitivity of distortion-product otoacoustic emissions to ototoxic hearing loss", Ear Hear, 29, pp.875~893 (2008)[DOI]
- Fausti SA, "High-frequency monitoring for early detection of cisplatin ototoxicity", Arch Otolaryngol Head Neck Surg, 119, pp.661~666 (1993)[DOI]
- Abujamra AL, "The use of high-frequency audiometry increases the diagnosis of asymptomatic hearing loss in pediatric patients treated with cisplatin-based chemotherapy", Pediatr Blood Cancer, 60, pp.474~478 (2013)[DOI]
- Geyer LB, "High frequency hearing thresholds and product distortion otoacoustic emissions in cystic fibrosis patients", Braz J Otorhinolaryngol, 81, pp.589~597 (2015)[DOI]
- Fausti SA, "Early detection of ototoxicity using 1", 6th-octave steps, 2003, pp.14, 444~450
- Fausti SA, "An individualized, sensitive frequency range for early detection of ototoxicity", Ear Hear, 20, pp.497~505 (1999)[DOI]
- Vaughan NE, "An efficient test protocol for identification of a limited, sensitive frequency test range for early detection of ototoxicity", J Rehabil Res Dev, 39, pp.567~574 (2002)
- Dille MF, "OtoID: new extended frequency, portable audiometer for ototoxicity monitoring", J Rehabil Res Dev, 50, pp.997~1006 (2013)[DOI]
- Konrad-Martin D, "Proposed comprehensive ototoxicity monitoring program for VA healthcare (COMP-VA)", J Rehabil Res Dev, 51, pp.81~100 (2014)[DOI]
- Stavroulaki P, "Otoacoustic emissions for monitoring aminoglycoside-induced ototoxicity in children with cystic fibrosis", Arch Otolaryngol Head Neck Surg, 128, pp.150~155 (2002)[DOI]
- Yilmaz S, "Detection of cisplatin-induced ototoxicity with transient evoked otoacoustic emission test before pure tone audiometer", Eur Arch Otorhinolaryngol, 267, pp.1041~1044 (2010)[DOI]
- Md Daud MK, "Ototoxicity screening of patients treated with streptomycin using distortion product otoacoustic emissions", B-ENT, 10, pp.53~58 (2014)
- 유광규, "Comparison of the Effectiveness of Monitoring Cisplatin-Induced Ototoxicity with Extended High-Frequency Pure-Tone Audiometry or Distortion-Product Otoacoustic Emission", Journal of Audiology & Otology, 18(2), pp.58~68 (2014), 대한청각학회
- Dille MF, "Ototoxicity risk assessment combining distortion product otoacoustic emissions with a cisplatin dose model", J Acoust Soc Am, 128, pp.1163~1174 (2010)[DOI]
- Reavis KM, "Distortion-product otoacoustic emission test performance for ototoxicity monitoring", Ear Hear, 32, pp.61~74 (2011)[DOI]
- Crundwell G, "Ototoxicity (cochleotoxicity) classifications: a review", Int J Audiol, 55, pp.65~74 (2016)[DOI]
- Chang KW, "Practical grading system for evaluating cisplatin ototoxicity in children", J Clin Oncol, 28, pp.1788~1795 (2010)[DOI]
- Theunissen EA, "A new grading system for ototoxicity in adults", Ann Otol Rhinol Laryngol, 123, pp.711~718 (2014)[DOI]
- Kushner BH, "Ototoxicity from high-dose use of platinum compounds in patients with neuroblastoma", Cancer, 107, pp.417~422 (2006)[DOI]
- Yancey A, "Risk factors for cisplatin-associated ototoxicity in pediatric oncology patients", Pediatr Blood Cancer, 59, pp.144~148 (2012)[DOI]
- Bertolini P, "Platinum compound-related ototoxicity in children: long-term follow-up reveals continuous worsening of hearing loss", J Pediatr Hematol Oncol, 26, pp.649~655 (2004)[DOI]
- Al-Khatib T, "Cisplatinum ototoxicity in children, long-term follow up", Int J Pediatr Otorhinolaryngol, 74, pp.913~919 (2010)[DOI]
- Kolinsky DC, "Late onset hearing loss: a significant complication of cancer survivors treated with cisplatin containing chemotherapy regimens", J Pediatr Hematol Oncol, 32, pp.119~123 (2010)[DOI]
- Ahmed RM, "Gentamicin ototoxicity: a 23-year selected case series of 103 patients", Med J Aust, 196, pp.701~704 (2012)[DOI]
- Rogers C, "Aminoglycoside-induced balance deficits: a review of vestibulotoxicity", S Afr Fam Pract, 53, pp.419~424 (2011)
- Fouladi M, "Amifostine protects against cisplatin-induced ototoxicity in children with average-risk medulloblastoma", J Clin Oncol, 26, pp.3749~3755 (2008)[DOI]
- Riga MG, "Transtympanic injections of N-acetylcysteine for the prevention of cisplatin-induced ototoxicity: a feasible method with promising efficacy", Am J Clin Oncol, 36, pp.1~6 (2013)[DOI]
- Gurney JG, "Evaluation of amifostine for protection against cisplatin- induced serious hearing loss in children treated for average-risk or high-risk medulloblastoma", Neuro Oncol, 16, pp.848~855 (2014)[DOI]
- Dias MA, "The chemopreventive effect of Ginkgo biloba extract 761 against cisplatin ototoxicity: a pilot study", Int Tinnitus J, 19, pp.12~19 (2015)
- Feldman L, "Gentamicin-induced ototoxicity in hemodialysis patients is ameliorated by N-acetylcysteine", Kidney Int, 72, pp.359~363 (2007)[DOI]
- Doolittle ND, "Delayed sodium thiosulfate as an otoprotectant against carboplatin-induced hearing loss in patients with malignant brain tumors", Clin Cancer Res, 7, pp.493~500 (2001)
- Marina N, "Amifostine does not protect against the ototoxicity of high-dose cisplatin combined with etoposide and bleomycin in pediatric germ-cell tumors: a Children's Oncology Group study", Cancer, 104, pp.841~847 (2005)[DOI]
- Katzenstein HM, "Amifostine does not prevent platinum-induced hearing loss associated with the treatment of children with hepatoblastoma: a report of the Intergroup Hepatoblastoma Study P9645 as a part of the Children's Oncology Group", Cancer, 115, pp.5828~5835 (2009)[DOI]
- Marshak T, "Prevention of cisplatin-induced hearing loss by intratympanic dexamethasone: a Randomized Controlled Study", Otolaryngol Head Neck Surg, 150, pp.983~990 (2014)[DOI]
- van As JW, "Medical interventions for the prevention of platinum-induced hearing loss in children with cancer", Cochrane Database Syst Rev (2014)
- Landier W, "Ototoxicity and cancer therapy", Cancer, 122, pp.1647~1658 (2016)[DOI]
- Lustig LR, "Cochlear gene therapy", Curr Opin Neurol, 25, pp.57~60 (2012)[DOI]
- Santaolalla F, "Inner ear hair cell regeneration: a look from the past to the future", Neural Regen Res, 8, pp.2284~2289 (2013)
