Effect of Tianeptine on Depressed Tinnitus Patients
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Background and Objectives: Tianeptine is a tricyclic antidepressant that has a novel pharmacological property: it increases the reuptake of 5-hydroxytryptamine. Recent studies have reported that the prevalence of depression is greater in patients with tinnitus than in control subjects who do not have tinnitus. The purpose of this study was to assess the efficacy of tianeptine for the relief of tinnitus, especially in patients with depressive mood. Subjects and Methods: Among a total of 52 tinnitus patients, 15 had depressive mood. The depressed tinnitus patients were prescribed Stablon® 12.5 mg once daily for 1 month without any other drug. We assessed the severity of tinnitus, level of depression, and the quality of sleep in these patients by using the Tinnitus Handicap Inventory (THI), Beck Depression Inventory (BDI), and Pittsburgh Sleep Quality Index (PSQI). Hearing impairment and severity of tinnitus were measured with pure tone audiometry, speech audiometry, and tinnitograms. These evaluations were conducted before and after medication treatment. Results: For the 15 depressed tinnitus patients, THI scores significantly correlated with BDI and PSQI scores prior to medication treatment. These results showed that the discomfort of tinnitus was closely related to depression and sleep disorder. After medication treatment, THI and BDI scores significantly decreased, indicating that tinnitus and depression improved. However, no significant alteration in PSQI score was observed, indicating that there was no improvement in sleep quality. Conclusions: In the treatment of depressed tinnitus patients, tianeptine might be an efficient drug to treat both tinnitus and depression. However, tianeptine is unlikely to improve the quality of sleep in these patients.
Abstract
Background and Objectives: Tianeptine is a tricyclic antidepressant that has a novel pharmacological property: it increases the reuptake of 5-hydroxytryptamine. Recent studies have reported that the prevalence of depression is greater in patients with tinnitus than in control subjects who do not have tinnitus. The purpose of this study was to assess the efficacy of tianeptine for the relief of tinnitus, especially in patients with depressive mood. Subjects and Methods: Among a total of 52 tinnitus patients, 15 had depressive mood. The depressed tinnitus patients were prescribed Stablon® 12.5 mg once daily for 1 month without any other drug. We assessed the severity of tinnitus, level of depression, and the quality of sleep in these patients by using the Tinnitus Handicap Inventory (THI), Beck Depression Inventory (BDI), and Pittsburgh Sleep Quality Index (PSQI). Hearing impairment and severity of tinnitus were measured with pure tone audiometry, speech audiometry, and tinnitograms. These evaluations were conducted before and after medication treatment. Results: For the 15 depressed tinnitus patients, THI scores significantly correlated with BDI and PSQI scores prior to medication treatment. These results showed that the discomfort of tinnitus was closely related to depression and sleep disorder. After medication treatment, THI and BDI scores significantly decreased, indicating that tinnitus and depression improved. However, no significant alteration in PSQI score was observed, indicating that there was no improvement in sleep quality. Conclusions: In the treatment of depressed tinnitus patients, tianeptine might be an efficient drug to treat both tinnitus and depression. However, tianeptine is unlikely to improve the quality of sleep in these patients.
참고문헌 (30)
- Woo YS, "Tianeptine combination for partial or non-response to selective serotonin re-uptake inhibitor monotherapy", Psychiatry Clin Neurosci, 67, pp.219~227 (2013)
- McEwen BS, "The neurobiological properties of tianeptine (Stablon):from monoamine hypothesis to glutamatergic modulation", Mol Psychiatry, 15, pp.237~249 (2010)
- Curzon G, "The effects of tianeptine and other antidepressants on a rat model of depression", Br J Psychiatry Suppl, (15), pp.51~55 (1992)
- Kelly JP, "The effect of tianeptine and sertraline in three animal models of depression", Neuropharmacology, 33, pp.1011~1016 (1994)
- Jastreboff PJ, "Phantom auditory perception (tinnitus): mechanisms of generation and perception", Neurosci Res, 8, pp.221~254 (1990)
- Martines F, "Investigation of tinnitus patients in Italy: clinical and audiological characteristics", Int J Otolaryngol, 2010, pp.265861~ (2010)
- Reynolds P, "Tinnitus and psychological morbidity:a cross-sectional study to investigate psychological morbidity in tinnitus patients and its relationship with severity of symptoms and illness perceptions", Clin Otolaryngol Allied Sci, 29, pp.628~634 (2004)
- Adoga AA, "Tinnitus and the prevalence of co-morbid psychological stress", Niger J Med, 17, pp.95~97 (2008)
- Pinto PC, "Tinnitus and its association with psychiatric disorders: systematic review", J Laryngol Otol, 128, pp.660~664 (2014)
- Zöger S, "Relationship between tinnitus severity and psychiatric disorders", Psychosomatics, 47, pp.282~288 (2006)
- Andersson G, "Longitudinal follow-up of tinnitus complaints", Arch Otolaryngol Head Neck Surg, 127, pp.175~179 (2001)
- Holgers KM, "Predictive factors for the severity of tinnitus", Audiology, 39, pp.284~291 (2000)
- Folmer RL, "Long-term reductions in tinnitus severity", BMC Ear Nose Throat Disord, 2, pp.3~ (2002)
- Salvi R, "Pharmacological treatments for tinnitus:nww and old", Drugs Future, 34, pp.381~400 (2009)
- Sullivan M, "A randomized trial of nortriptyline for severe chronic tinnitus. Effects on depression, disability, and tinnitus symptoms", Arch Intern Med, 153, pp.2251~2259 (1993)
- Robinson SK, "Antidepressant therapy in tinnitus", Hear Res, 226, pp.221~231 (2007)
- Rhee MK, "A standardization study of Beck Depression Inventory I Korean version (K-BDI): reliability and factor analysis", Korean J Psychopathol, 4, pp.77~95 (1995)
- 김지혜, "한국어 번역판 Tinnitus Handicap Inventory의 신뢰도 및 타당도 연구", 대한이비인후과학회지 두경부외과학, 45(4), pp.328~334 (2002), 대한이비인후과학회
- Buysse DJ, "The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research", Psychiatry Res, 28, pp.193~213 (1989)
- Folmer RL, "Tinnitus severity, loudness, and depression", Otolaryngol Head Neck Surg, 121, pp.48~51 (1999)
- Zöger S, "The effects of sertraline on severe tinnitus suffering--a randomized, double-blind, placebo-controlled study", J Clin Psychopharmacol, 26, pp.32~39 (2006)
- Dobie RA, "Antidepressant treatment of tinnitus patients. Interim report of a randomized clinical trial", Acta Otolaryngol, 112, pp.242~247 (1992)
- Zöger S, "Psychiatric disorders in tinnitus patients without severe hearing impairment: 24 month follow-up of patients at an audiological clinic", Audiology, 40, pp.133~140 (2001)
- Dobie RA, "Depression and tinnitus", Otolaryngol Clin North Am, 36, pp.383~388 (2003)
- Bayar N, "Efficacy of amitriptyline in the treatment of subjective tinnitus", J Otolaryngol, 30, pp.300~303 (2001)
- Folmer RL, "SSRI use by tinnitus patients: interactions between depression and tinnitus severity", Ear Nose Throat J, 83, pp.107~108 (2004)
- Dobie RA, "Antidepressant treatment of tinnitus patients: report of a randomized clinical trial and clinical prediction of benefit", Am J Otol, 14, pp.18~23 (1993)
- Shea JJ, "Medical treatment of tinnitus", Ann Otol Rhinol Laryngol, 90(6 Pt 1), pp.601~609 (1981)
- Gallinat J, "Allelic variants of the functional promoter polymorphism of the human serotonin transporter gene is associated with auditory cortical stimulus processing", Neuropsychopharmacology, 28, pp.530~532 (2003)
- Simpson JJ, "A review of evidence in support of a role for 5-HT in the perception of tinnitus", Hear Res, 145, pp.1~7 (2000)