Conceptual design of hybrid target for molybdenum-99 production based on heavywater
1
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Molybdenum-99 (99Mo) is used for preparing Technetium-99 m (99mTc), which is the most widely used isotope in nuclear medicine. In this work, a study for 99Mo production based on a high-power electron accelerator has been performed as an alternative approach to produce 99mTc. In this study, Monte Carlo MCNPX2.6 code has been used to examine a novel idea of simultaneous hybrid production of 99Mo via both photoneutron and neutron capture reactions using an electron accelerator in heavy water tank. It is expected that this conceptual design including an arrangement of metallic plates of 100Mo and 98Mo produces total activity of 97.5 Ci at the end of 20-h continuous e-beam irradiation (30 MeV, 10 mA)
Abstract
Molybdenum-99 (99Mo) is used for preparing Technetium-99 m (99mTc), which is the most widely used isotope in nuclear medicine. In this work, a study for 99Mo production based on a high-power electron accelerator has been performed as an alternative approach to produce 99mTc. In this study, Monte Carlo MCNPX2.6 code has been used to examine a novel idea of simultaneous hybrid production of 99Mo via both photoneutron and neutron capture reactions using an electron accelerator in heavy water tank. It is expected that this conceptual design including an arrangement of metallic plates of 100Mo and 98Mo produces total activity of 97.5 Ci at the end of 20-h continuous e-beam irradiation (30 MeV, 10 mA)
참고문헌 (33)
- The Supply of Medical Radioisotopes. Medical Isotope Supply in the Future: Production Capacity and Demand, Forecast for the 99mo, "99mTc market, 2015-2020", P. Peykov, 2014
- National Academies of Sciences, Engineering, and Medicine, "Molybdenum-99for Medical Imaging" (2016), National Academies Press
- National Research Council, "Medical Isotope Production without Highly Enriched Uranium" (2009), National Academies Press
- J. T. Bushberg, "The Essential Physics of Medical Imaging" (2020), Lippincott Williams & Wilkins
- International Atomic Energy Agency, "Feasibility of producing molybdenum-99on a small scale using fission of low enriched uranium or neutron activation of natural molybdenum" (2015), IAEA
- 이승곤, "Development of Industrial-Scale Fission 99Mo Production Process Using Low Enriched Uranium Target", Nuclear Engineering and Technology, 48(3), pp.613~623 (2016), 한국원자력학회
- J. R. Ballinger, "Short-and long-term responses to molybdenum-99 shortages in nuclear medicine", Br. J. Radiol, 83, pp.899~901 (2010)
- "Predictions Regarding the Supply of 99Mo and 99mTc when NRU Ceases Production in" (2015)[URL]
- Accelerator-based alternatives to non-HEU production of Tc-99m, in: Final Report of the Coordinated Research Project on “Accelerator-Based Alternatives to Non-HEU Production of Mo-99, "Tc-99m", J. Esposito, 2014, pp.110~119
- K. Mang’era, "Processing and evaluation of linear acceleratorproduced 99Mo", 99mTc in Canada, 2015, pp.305, 79~85
- M. A. Brown, "Recovery of high specific activity molybdenum-99 from accelerator-induced fission on low-enriched uranium for technetium-99m generators", Sci. Rep, 11, pp.13292~ (2021)
- M. R. A. Rovais, "Assessment of the direct cyclotron production of 99mTc : an approach to crisis management of 99mTc shortage", Appl. Radiat. Isot, 112, pp.55~61 (2016)
- Cyclotron Based Production of Technetium-99m, "International Atomic Energy Agency", International Atomic Energy Agency, ~, pp.IAEA Radioisotopes and Radiopharmaceuticals Reports No. 2 (2017)
- A. Tsechanski, "Electron accelerator-based production of molybdenum-99: Bremsstrahlung and photoneutron generation from molybdenum vs . tungsten", Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 366, pp.124~139 (2016), Elsevier BV[DOI]
- J. Jang, "Design of an X-band electron linear accelerator dedicated to decentralized 99Mo99mTc supply : from beam energy selection to yield estimation", Phys. Rev. Accel. Beams, 20, pp.104701~ (2017)
- Results of the Six-Day Electron-Accelerator Irradiation of Enriched Mo-100 Targets for the Production of Mo-99, "S. Chemerisov", Argonne National Laboratory (ANL), ~ (2019)
- J. McCarter, "Accelerator Production of Mo-99 Using Mo-100" (2021), JACoW Publishing
- A. Shaikh, "GEANT4 based simulation study of converter and direct target design and optimization of target for 99Mo production using 30 MeV electron linear accelerator", Appl. Radiat. Isot, 185, pp.110239~ (2022)
- J. Jang, "Design and testing of a W-MoO3 target system for electron linac production of 99Mo", 99mTc, 2021, pp.987, 164815~
- J.M. Bassaler, "Rhodotron: an accelerator for industrial irradiation", Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 68(1-4), pp.92~95 (1992), Elsevier BV[DOI]
- "Rhodotron E-Beam Accelerator"[URL]
- MCNPX User’s Manual, Version 2.4. 0., , ~, pp.Report LA-CP-02-408 (2002)
- F. Torabi, "Photoneutron production by a 25MeV electron linac for BNCT application", Ann. Nucl. Energy, 54, pp.192~196 (2013)
- A. Taghibi Khotbeh-Saraa, "Feasibility study of Mo-99 production using high-power electron Linac : nuclear and thermalmechanical analysis based on photoneutron interaction", Radiation Physics and Engineering, 2, pp.9~17 (2021)
- M. J. Berger, "Bremsstrahlung and photoneutrons from thick tungsten and tantalum targets", Phys. Rev. C : Nucl. Phys, 2, pp.621~631 (1970)
- M. Salehi, "New beam delivery system design for industrial electron accelerator at Nuclear Science and Technology Research Institute", Appl. Radiat. Isot, 184, pp.110220~ (2022)
- S. Howard, "Target optimization for the photonuclear production of radioisotopes", Appl. Radiat. Isot, 96, pp.162~167 (2015)
- K. S. Krane, "Introductory Nuclear Physics" (1991), John Wiley & Sons
- A. Taghibi Khotbeh-Sara, "Feasibility Study on Mo-99Production Using Hybrid Method Based on High Power Electron Accelerator", pp.3462~3465 (2019), JACoW Publishing
- "JANIS Book of Neutron-Induced Cross-Sections" (2020)[URL]
- J. Meija, "Isotopic compositions of the elements 2013 (IUPAC technical report)", J. Macromol. Sci. Part A Pure Appl. Chem, 88, pp.293~306 (2016)
- T. M. Martin, "Production of 99Mo", 99mTc via photoneutron reaction using natural molybdenum and enriched 100Mo: part 1, theoretical analysis, 2017, pp.314, 1051~1062
- محسن طبسی, "ارزیابی زنجیره تأمین رادیونوکلید مولیبدن-99 از طریق شکافت اورانیم با غنای پایین در ایران", مجله علوم و فنون هسته ای, 42(3), pp.104~110 (2021), SciTech Solutions[DOI]
