전탕용수의 미네랄 함량이 두충의 유효성분 추출에 미치는 영향 분석
Influences of mineral contents in decoction water on the extraction efficiency of bioactive compounds from Eucommiae Cortex
0
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Objective: Eucommiae Cortex is bark of Eucommia ulmoides Oliver, a deciduous tree native to China. Today, teas or herbal drugs made from E. ulmoides leaves are widely consumed as a healthy food especially in Eastern Asia including Japan, China and Korea. This study was aimed to verify the extraction efficiency of bioactive compounds from Eucommiae Cortex depending on characteristics of decoction water. Method: Six types of decoction water with various origin were prepared and the contents of minerals in water were analyzed by ICP-AES and ICP-MS. The contents of extracted bioactive compounds were analyzed by HPLC and the relationship between mineral contents and extracted bioactive compounds in the decoction water were analysed by multiple factor analysis. The decoction waters could be classified in three groups by hierarchical cluster analysis. Result: Extracted amounts of compounds in Eucommiae Cortex showed a positive relationship with Na, Si, K concentration in decoction water, while a negative relationship with Ca, Mg concentration. Conclusion: The study proved that the minerals in water influenced the extraction efficiency of bioactive compounds from Eucommiae Cortex.
Abstract
Objective: Eucommiae Cortex is bark of Eucommia ulmoides Oliver, a deciduous tree native to China. Today, teas or herbal drugs made from E. ulmoides leaves are widely consumed as a healthy food especially in Eastern Asia including Japan, China and Korea. This study was aimed to verify the extraction efficiency of bioactive compounds from Eucommiae Cortex depending on characteristics of decoction water. Method: Six types of decoction water with various origin were prepared and the contents of minerals in water were analyzed by ICP-AES and ICP-MS. The contents of extracted bioactive compounds were analyzed by HPLC and the relationship between mineral contents and extracted bioactive compounds in the decoction water were analysed by multiple factor analysis. The decoction waters could be classified in three groups by hierarchical cluster analysis. Result: Extracted amounts of compounds in Eucommiae Cortex showed a positive relationship with Na, Si, K concentration in decoction water, while a negative relationship with Ca, Mg concentration. Conclusion: The study proved that the minerals in water influenced the extraction efficiency of bioactive compounds from Eucommiae Cortex.
참고문헌 (23)
- 생약학교재편찬위원회, "생약학" (2010), 동명사
- Son KH, "Isolation and quantitative determination of geniposide from the Cortex of Eucommia ulmoides Oliver", Kor J Pharmacogn, 32(2), pp.89~92 (2001)
- Li Y, "The promoting effects of geniposidic acid and aucubin in Eucommia ulmoides Oliver leaves on collagen synthesis", Biol Pharm Bull, 21(12), pp.1306~1310 (1998)
- Feng SM, "Preparative isolation and purification of the lignan pinoresinol diglucoside and liriodendrin from the bark of Eucommia ulmoides Oliv. by high speed countercurrent chromatography", J Liq Chromatogr Relat Technol, 30(1), pp.135~145 (2007)
- Luo XB, "Analysis of nine bioactive compounds in Eucommia ulmoides Oliv. and their preparation by HPLC photo-diode array detection and mass spectrometry", J Liq Chromatogr Relat Technol, 27(1), pp.63~81 (2004)
- Bamba T, "Analysis of long-chain polyprenols using supercritical fluid chromatography and matrix-assisted laser desorption ionization time-of-flight mass spectrometry", J Chro-matogr A, 995(1-2), pp.203~207 (2003)
- 주옥수, "ACE Inhibitory Lignan Glycosides Isolated from Eucommia ulmoides Oliver", 생명과학회지, 19(6), pp.698~704 (2009), 한국생명과학회
- Li Y, "The promoting effects of eucommiol from Eucommiae cortex on collagen synthesis", Bio Pharm Bull, 23(1), pp.54~59 (2000)
- Sih CJ, "Letter: Isolation and synthesis of pinoresinol diglucoside, a major antihypertensive principle of Tu-Chung (Eucommia ulmoides, Oliver)", J Am Chem Soc, 98(17), pp.5412~5413 (1976)
- Soka T, "Encyclopedia of Chinese Drugs", pp.1964~1966 (1985), Shanghai Science Technology Shogakukan Press
- Zhou Y, "Protective effects of Eucommia ulmoides Oliv. bark and leaf on amyloid β-induced cytotoxicity", Environ Toxicol Pharmacol, 28(3), pp.342~349 (2009)
- Lang C, "Effect of Eucommia ulmoides on systolic blood pressure in the spontaneous hyper-tensive rat", Am J Chin Med, 33(2), pp.215~230 (2005)
- Miura T, "Hypoglycemic activity and structure-activity relationship of iridoidal glycosides", Biol Pharm Bull, 19(1), pp.160~161 (1996)
- Lee MK, "Hypo-glycemic effect of Du-zhong (Eucommia ulmoides Oliv.) leaves in streptozotocin-induced diabetic rats", Diabetes Res Clin Prac, 67(1), pp.22~28 (2005)
- Park SA, "Hypoglycemic and hypolipidemic action of Du-zhong (Eucommia ulmoides Oliver) leaves water extract in C57BL", Ksj-db, J Ethnopharm, pp.2006, 107(3)[DOI]
- Sih CJ, "Letter: Isolation and synthesis of pinoresinol diglucoside, a major antihypertensive principle of Tu-Chung (Eucommia ulmoides, Oliver)", J Am Chem Soc, 98(17), pp.5412~5413 (1976)
- Kim YK, "The decocting and taking methods of herbal medicines", Kor J Ori Med, 10(2), pp.63~72 (2004)
- 김무경, "일부 무기질의 생수 중 함량 분석과 생수를 통한 섭취량 평가", 대한영양사협회 학술지, 16(2), pp.116~121 (2010), 대한영양사협회
- You EH, "A study on the water quality of domestic mineral water", Kor J Env Health Soc, 16(2), pp.41~45 (1990)
- 강종성, "패턴분석법에 의한 대황의 비교 연구", 생약학회지, 39(3), pp.179~185 (2008), 한국생약학회
- Xiao-Jie Li, "Species Classification and Quality Assessment of Chaihu (Radix Bupleuri) Based on High-Performance Liquid Chromatographic Fingerprint and Combined Chemometrics Methods", Archives of Pharmacal Research, 34(6), pp.961~969 (2011), 대한약학회
- 장유선, "전탕용수의 종류에 따른 대황 성분의 추출효과", 분석과학, 24(1), pp.38~44 (2011), 한국분석과학회
- Metori K, "The prevention effect of ginseng with Du-zhong leaf extract on plasma and protein meta-bolism in aging", Biol Pharm Bull, 20(3), pp.237~242 (1997)