Whole Brain Voxel-Wise Analysis of Cerebral Retention of Beta-Amyloid in Cognitively Normal Older Adults Using 18F-Florbetaben
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Objective: Recently developed 18F-labelled amyloid beta (Aβ) positron emission tomography (PET) tracers have demonstrated potentials to enable more prevalent application of amyloid imaging in the clinical setting. The aim of this study is to demonstrate cerebral retention of Aβ in cognitively normal older adults, by implementing voxel-based analysis on images acquired from 18F-Florbetaben amyloid PET. Methods: Fifty cognitive normal elderly subjects were recruited and included in the study. Demographic data and cognitive measurements were collected. Magnetic resonance imaging (MRI) and 18F-Florbetaben PET data were obtained followed by whole brain voxel-based analysis. Results: Compared to the florbetaben (FBB) (-) counterpart, FBB (+) showed significantly higher Aβ deposition in the brain regions comprising anterior cingulate, middle cingulate, posterior cingulate and precuneus (family wise error corrected p<0.05). There was no significant correlation between amyloid retention and cognitive functions. Conclusion: Our results confirms previous results regarding Aβ deposition by using 18F-Florbetaben, demonstrating potentials in application of 18F-Florbetaben PET imaging in clinical settings.
Abstract
Objective: Recently developed 18F-labelled amyloid beta (Aβ) positron emission tomography (PET) tracers have demonstrated potentials to enable more prevalent application of amyloid imaging in the clinical setting. The aim of this study is to demonstrate cerebral retention of Aβ in cognitively normal older adults, by implementing voxel-based analysis on images acquired from 18F-Florbetaben amyloid PET. Methods: Fifty cognitive normal elderly subjects were recruited and included in the study. Demographic data and cognitive measurements were collected. Magnetic resonance imaging (MRI) and 18F-Florbetaben PET data were obtained followed by whole brain voxel-based analysis. Results: Compared to the florbetaben (FBB) (-) counterpart, FBB (+) showed significantly higher Aβ deposition in the brain regions comprising anterior cingulate, middle cingulate, posterior cingulate and precuneus (family wise error corrected p<0.05). There was no significant correlation between amyloid retention and cognitive functions. Conclusion: Our results confirms previous results regarding Aβ deposition by using 18F-Florbetaben, demonstrating potentials in application of 18F-Florbetaben PET imaging in clinical settings.
참고문헌 (19)
- Hardy J, "The amyloid hypothesis of Alzheimer’s disease : progress and problems on the road to therapeutics", Science, 297, pp.353~356 (2002)
- Schmidt ME, "The influence of biological and technical factors on quantitative analysis of amyloid PET : points to consider and recommendations for controlling variability in longitudinal data", Alzheimers Dement, 11, pp.1050~1068 (2015)
- Klunk WE, "Imaging brain amyloid in Alzheimer’s disease with Pittsburgh Compound-B", Ann Neurol, 55, pp.306~319 (2004)
- Florbetaben : a review in beta-amyloid PET imaging in cognitive impairment, "CNS Drugs", 2015, 605~613
- Sabri O, "Florbetaben PET imaging to detect amyloid beta plaques in Alzheimer’s disease : phase 3 study", Alzheimers Dement, 11, pp.964~974 (2015)
- Lim HK, "Regional amyloid burden and intrinsic connectivity networks in cognitively normal elderly subjects", Brain, 137, pp.3327~3338 (2014)
- Aizenstein HJ, "Frequent amyloid deposition without significant cognitive impairment among the elderly", Arch Neurol, 65, pp.1509~1517 (2008)
- Morris JC, "The Clinical Dementia Rating(CDR) : current version and scoring rules", Neurology, 43, pp.2412~2414 (1993)
- Lee JH, "Development of the Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease Assessment Packet (CERAD-K): clinical and neuropsychological assessment batteries", J Gerontol B Psychol Sci Soc Sci, 57, pp.P47~P53 (2002)
- Ashburner J, "Unified segmentation", Neuroimage, 26, pp.839~851 (2005)
- and hyperphosphorylated tau synergy drives metabolic decline in preclinical Alzheimer’s disease, "Mol Psychiatry", 2017, 306~311
- Wu KY, "Beta-amyloid deposition and cognitive function in patients with major depressive disorder with different subtypes of mild cognitive impairment : 18(F)-florbetapir(AV-45", Amyvid)PET study, 2016, pp.43, 1067~1076
- Sabbagh MN, "Florbetapir PET, FDG PET, and MRI in Down syndrome individuals with and without Alzheimer’s dementia", Alzheimers Dement, 11, pp.994~1004 (2015)
- Hanseeuw B, "Patients with amyloid-negative mild cognitive impairment have cortical hypometabolism but the hippocampus is preserved", J Alzheimers Dis, 53, pp.651~660 (2016)
- Greicius M, "Resting-state functional connectivity in neuropsychiatric disorders", Curr Opin Neurol, 21, pp.424~430 (2008)
- Myers N, "Within-patient correspondence of amyloid-β and intrinsic network connectivity in Alzheimer’s disease", Brain, 137, pp.2052~2064 (2014)
- Whitfield-Gabrieli S, "Default mode network activity and connectivity in psychopathology", Annu Rev Clin Psychol, 8, pp.49~76 (2012)
- Cohen AD, "Basal cerebral metabolism may modulate the cognitive effects of Abeta in mild cognitive impairment : an example of brain reserve", J Neurosci, 29, pp.14770~14778 (2009)
- Florbetaben : a review in β-Amyloid PET imaging in cognitive impairment, "CNS Drugs", 2015, 605~613