Association of Apolipoprotein E Polymorphisms with White Matter Lesions and Brain Atrophy
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Objective Apolipoprotein E (ApoE) is mainly synthesized in the liver. So far, it is unknown the relationship among APOE gene polymorphisms and WML, brain atrophy. Therefore, the aim of the study was to assess the associations of APOE gene polymorphisms in patients with WML and brain atrophy. Methods A total of 58 patients with WML, 128 patients with brain atrophy, 112 patients with co-occurrence of WML and brain atrophy and 95 healthy elderly volunteers were recruited from Renmin Hospital of WuHan University. Results Allele E3 was the most common allele. The alleles E2 had significantly higher levels of ApoB and lower age in WML group. The alleles E2 was associated with the lower level of ApoB, LDL-Ch, TCh, and sdLDL in co-occurrence group. The E3/E3 genotype has higher level of sdLDL, but lower age and female frequency in WML. The E3/E4 genotype had higher level of TG, but lower age in WML. Gender, Age, E2, Hyperhomocysteinemia and UA were also significantly associated with disease progression. Conclusion This study found that clinical data, lipids and metabolic complications were closely related to ApoE genotypes and alleles, and also disease progression and type.
Abstract
Objective Apolipoprotein E (ApoE) is mainly synthesized in the liver. So far, it is unknown the relationship among APOE gene polymorphisms and WML, brain atrophy. Therefore, the aim of the study was to assess the associations of APOE gene polymorphisms in patients with WML and brain atrophy. Methods A total of 58 patients with WML, 128 patients with brain atrophy, 112 patients with co-occurrence of WML and brain atrophy and 95 healthy elderly volunteers were recruited from Renmin Hospital of WuHan University. Results Allele E3 was the most common allele. The alleles E2 had significantly higher levels of ApoB and lower age in WML group. The alleles E2 was associated with the lower level of ApoB, LDL-Ch, TCh, and sdLDL in co-occurrence group. The E3/E3 genotype has higher level of sdLDL, but lower age and female frequency in WML. The E3/E4 genotype had higher level of TG, but lower age in WML. Gender, Age, E2, Hyperhomocysteinemia and UA were also significantly associated with disease progression. Conclusion This study found that clinical data, lipids and metabolic complications were closely related to ApoE genotypes and alleles, and also disease progression and type.
참고문헌 (31)
- Das HK, "Isolation, characterization, and mapping to chromosome 19 of the human apolipoprotein E gene", J Biol Chem, 260, pp.6240~6247 (1985)
- Svobodova H, "Apolipoprotein E gene polymorphism in the Mongolian population", Folia Biol(Praha), 53, pp.138~142 (2007)
- Yousuf FA, "Review : Apolipoprotein E(Apo E)gene polymorphism and coronary heart disease in Asian populations", Pak J Pharm Sci, 28, pp.1439~1444 (2015)
- Kotaska K, "Correlation between common genetic variants and risk factors associated with prediction of cardiovascular diseases in dyslipidemic patients", Genet Test Mol Biomarkers, 16, pp.210~214 (2012)
- Muller M, "Brain atrophy and cognition : interaction with cerebrovascular pathology", Neurobiol Aging, 32, pp.885~893 (2011)
- Resnick SM, "Longitudinal magnetic resonance imaging studies of older adults : a shrinking brain", J Neurosci, 23, pp.3295~3301 (2003)
- Hachinski VC, "Leuko-araiosis : an ancient term for a new problem", Can J Neurol Sci, 13, pp.533~534 (1986)
- Raji CA, "White matter lesions and brain gray matter volume in cognitively normal elders", Neurobiol Aging, 33, pp.834.e7~834.e16 (2012)
- Schmidt R, "MRI-detected white matter lesions: do they really matter?", J Neural Transm (Vienna), 118, pp.673~681 (2011)
- Appelman AP, "White matter lesions and brain atrophy : more than shared risk factors? A systematic review", Cerebrovasc Dis, 28, pp.227~242 (2009)
- Callisaya ML, "Type 2 diabetes mellitus, brain atrophy and cognitive decline in older people : a longitudinal study", Diabetologia, 62, pp.448~458 (2019)
- Richter N, "White matter lesions and the cholinergic deficit in aging and mild cognitive impairment", Neurobiol Aging, 53, pp.27~35 (2017)
- Alaylioglu M, "The association between clusterin and APOE polymorphisms and late-onset alzheimer disease in a Turkish cohort", J Geriatr Psychiatry Neurol, 29, pp.221~226 (2016)
- Araki S, "APOE polymorphisms and the development of diabetic nephropathy in type 1 diabetes : results of case-control and family-based studies", Diabetes, 49, pp.2190~2195 (2000)
- Rudilosso S, "Evaluation of white matter hypodensities on computed tomography in stroke patients using the Fazekas score", Clin Imaging, 46, pp.24~27 (2017)
- 정은오, "Effectiveness of Cortical Atrophy Scale and Indirect Indices of Brain Atrophy to Predict Chronic Subdural Hematoma in Older Patients", Korean Journal of Neurotrauma, 12(2), pp.112~117 (2016), 대한신경손상학회[DOI]
- Reymer PW, "Apolipoprotein E genotyping on agarose gels", Clin Chem, 41, pp.1046~1047 (1995)
- Aribisala BS, "Brain atrophy associations with white matter lesions in the ageing brain : the Lothian Birth Cohort 1936", Eur Radiol, 23, pp.1084~1092 (2013)
- Schwichtenberg J, "Late-onset major depression is associated with age-related white matter lesions in the brainstem", Int J Geriatr Psychiatry, 32, pp.446~454 (2017)
- Conte MS, "Pro-resolving lipid mediators in vascular disease", J Clin Invest, 128, pp.3727~3735 (2018)
- Sattar N, "Advances in the clinical management of type 2 diabetes : a brief history of the past 15 years and challenges for the future", BMC Med, 17, pp.46~ (2019)
- Wassink AM, "Metabolic syndrome and incidence of type 2 diabetes in patients with manifest vascular disease", Diab Vasc Dis Res, 5, pp.114~122 (2008)
- Han S, "Serum apolipoprotein E concentration and polymorphism influence serum lipid levels in Chinese Shandong Han population", Medicine (Baltimore), 95, pp.e5639~ (2016)
- Liu H, "Apolipoprotein E polymorphism and the risk of intracranial aneurysms in a Chinese population", BMC Neurol, 16, pp.14~ (2016)
- Zhong Z, "Association of APOE Gene Polymorphisms with Cerebral Infarction in the Chinese Population", Med Sci Monit, 24, pp.1171~1177 (2018)
- Bea AM, "Lipid-lowering response in subjects with the p.(Leu167del) mutation in the APOE gene", Atherosclerosis, 282, pp.143~147 (2019)
- Liu L, "Dietary DHA", EPA ratio changes fatty acid composition and attenuates diet-induced accumulation of lipid in the liver of ApoE(-, Oxid Med Cell Longev, pp.2018, 2018[DOI]
- Larifla L, "Association of APOE gene polymorphism with lipid profile and coronary artery disease in Afro-Caribbeans", PLoS One, 12, pp.e0181620~ (2017)
- Raffeld MR, "APOE epsilon4 and lipid levels affect risk of recurrent nonlobar intracerebral hemorrhage", Neurology, 85, pp.349~356 (2015)
- Mendrick DL, "Metabolic syndrome and associated diseases : from the bench to the clinic", Toxicol Sci, 162, pp.36~42 (2018)
- Vikram NK, "Cardiovascular and metabolic complications-diagnosis and management in obese children", Indian J Pediatr, 85, pp.535~545 (2018)