Additive Burden of Abnormal Diffusivity in the Brain with Schizophrenia: A Diffusion Tensor Imaging Study with Public Neuroimaging Data
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Objective Diffusion tensor imaging has been extensively applied to schizophrenia research. In this study, we counted the number of abnormal brain regions with altered diffusion measures in patients with schizophrenia to enumerate the burden of abnormal diffusivity in the brain. Methods The public neuroimaging data of the COBRE project from SchizConnect were used for the study. The studied dataset consisted of data from 57 patients with schizophrenia and 71 healthy participants. FreeSurfer and FSL were applied for image processing and analysis. After verifying 161 regions of interest (ROIs), mean diffusion measures in every single ROI in all study participants were measured and normalized into Z-scores. Each ROI was then defined as normal or abnormal on the basis of a cutoff absolute Z-score of 1.96. The number of abnormal ROIs was obtained by each diffusion measure. Results The numbers of ROIs with increased radial diffusivity and increased trace were significantly larger in the patient group than in healthy participants. Conclusion Thus, the patient group showed a significant increase in abnormal ROIs, strongly indicating that schizophrenia is not caused by the pathology of a single brain region, but is instead attributable to the additive burden of structural alterations within multiple brain regions.
Abstract
Objective Diffusion tensor imaging has been extensively applied to schizophrenia research. In this study, we counted the number of abnormal brain regions with altered diffusion measures in patients with schizophrenia to enumerate the burden of abnormal diffusivity in the brain. Methods The public neuroimaging data of the COBRE project from SchizConnect were used for the study. The studied dataset consisted of data from 57 patients with schizophrenia and 71 healthy participants. FreeSurfer and FSL were applied for image processing and analysis. After verifying 161 regions of interest (ROIs), mean diffusion measures in every single ROI in all study participants were measured and normalized into Z-scores. Each ROI was then defined as normal or abnormal on the basis of a cutoff absolute Z-score of 1.96. The number of abnormal ROIs was obtained by each diffusion measure. Results The numbers of ROIs with increased radial diffusivity and increased trace were significantly larger in the patient group than in healthy participants. Conclusion Thus, the patient group showed a significant increase in abnormal ROIs, strongly indicating that schizophrenia is not caused by the pathology of a single brain region, but is instead attributable to the additive burden of structural alterations within multiple brain regions.
참고문헌 (72)
- Hegarty JD, "One hundred years of schizophrenia : a meta-analysis of the outcome literature", Am J Psychiatry, 151, pp.1409~1416 (1994)
- Winkelman NW, "Observations on the histopathology of schizophrenia; the cortex", Am J Psychiatry, 105, pp.889~896 (1949)
- Le Bihan D, "Diffusion tensor imaging : concepts and applications", J Magn Reson Imaging, 13, pp.534~546 (2001)
- Taylor WD, "Diffusion tensor imaging : background, potential, and utility in psychiatric research", Biol Psychiatry, 55, pp.201~207 (2004)
- Basser PJ, "MR diffusion tensor spectroscopy and imaging", Biophys J, 66, pp.259~267 (1994)
- Kubicki M, "DTI and MTR abnormalities in schizophrenia : analysis of white matter integrity", Neuroimage, 26, pp.1109~1118 (2005)
- Kubicki M, "A review of diffusion tensor imaging studies in schizophrenia", J Psychiatr Res, 41, pp.15~30 (2007)
- Ellison-Wright I, "Meta-analysis of diffusion tensor imaging studies in schizophrenia", Schizophr Res, 108, pp.3~10 (2009)
- Kelly S, "Widespread white matter microstructural differences in schizophrenia across 4322 individuals : results from the ENIGMA Schizophrenia DTI Working Group", Mol Psychiatry, 23, pp.1261~1269 (2018)
- Pierpaoli C, "Toward a quantitative assessment of diffusion anisotropy", Magn Reson Med, 36, pp.893~906 (1996)
- Kyriakopoulos M, "Diffusion tensor imaging in schizophrenia", Eur Psychiatry, 23, pp.255~273 (2008)
- Whitford TJ, "Diffusion tensor imaging, structural connectivity, and schizophrenia", Schizophr Res Treatment, 2011, pp.709523~ (2011)
- Alexander AL, "Diffusion tensor imaging of the brain", Neurotherapeutics, 4, pp.316~329 (2007)
- Buchsbaum MS, "MRI white matter diffusion anisotropy and PET metabolic rate in schizophrenia", Neuroreport, 9, pp.425~430 (1998)
- Agartz I, "Abnormal brain white matter in schizophrenia : a diffusion tensor imaging study", Neuroreport, 12, pp.2251~2254 (2001)
- Hubl D, "Pathways that make voices : white matter changes in auditory hallucinations", Arch Gen Psychiatry, 61, pp.658~668 (2004)
- Lener MS, "White matter abnormalities in schizophrenia and schizotypal personality disorder", Schizophr Bull, 41, pp.300~310 (2015)
- Kubicki M, "Cingulate fasciculus integrity disruption in schizophrenia : a magnetic resonance diffusion tensor imaging study", Biol Psychiatry, 54, pp.1171~1180 (2003)
- Sun Z, "Abnormal anterior cingulum in patients with schizophrenia : a diffusion tensor imaging study", Neuroreport, 14, pp.1833~1836 (2003)
- Fitzsimmons J, "Cingulum bundle diffusivity and delusions of reference in first episode and chronic schizophrenia", Psychiatry Res, 224, pp.124~132 (2014)
- Okugawa G, "Subtle disruption of the middle cerebellar peduncles in patients with schizophrenia", Neuropsychobiology, 50, pp.119~123 (2004)
- Ashtari M, "Disruption of white matter integrity in the inferior longitudinal fasciculus in adolescents with schizophrenia as revealed by fiber tractography", Arch Gen Psychiatry, 64, pp.1270~1280 (2007)
- Lee K, "Increased diffusivity in superior temporal gyrus in patients with schizophrenia : a Diffusion Tensor Imaging study", Schizophr Res, 108, pp.33~40 (2009)
- Kalus P, "New evidence for involvement of the entorhinal region in schizophrenia : a combined MRI volumetric and DTI study", Neuroimage, 24, pp.1122~1129 (2005)
- Moriya J, "Gray and white matter volumetric and diffusion tensor imaging(DTI)analyses in the early stage of first-episode schizophrenia", Schizophr Res, 116, pp.196~203 (2010)
- Friston KJ, "Dysfunctional connectivity in schizophrenia", World Psychiatry, 1, pp.66~71 (2002)
- Joo SW, "Altered white matter connectivity in patients with schizophrenia : an investigation using public neuroimaging data from SchizConnect", PLoS One, 13, pp.e0205369~ (2018)
- Shon SH, "Deterioration in global organization of structural brain networks in schizophrenia : a diffusion MRI tractography study", Front Psychiatry, 9, pp.272~ (2018)
- Lee JS, "Increased diffusivity in gray matter in recent onset schizophrenia is associated with clinical symptoms and social cognition", Schizophr Res, 176, pp.144~150 (2016)
- HyunJung Kim, "Gray Matter Microstructural Abnormalities and Working Memory Deficits in Individuals with Schizophrenia", PSYCHIATRY INVESTIGATION, 16(3), pp.234~243 (2019), 대한신경정신의학회[DOI]
- Kanaan RA, "Diffusion tensor imaging in schizophrenia", Biol Psychiatry, 58, pp.921~929 (2005)
- Lawrie SM, "Brain structure, genetic liability, and psychotic symptoms in subjects at high risk of developing schizophrenia", Biol Psychiatry, 49, pp.811~823 (2001)
- International Schizophrenia Consortium, "Common polygenic variation contributes to risk of schizophrenia and bipolar disorder", Nature, 460, pp.748~752 (2009)
- Çetin MS, "Thalamus and posterior temporal lobe show greater inter-network connectivity at rest and across sensory paradigms in schizophrenia", Neuroimage, 97, pp.117~126 (2014)
- Jenkinson M, "FSL", Neuroimage, 62, pp.782~790 (2012)
- Jenkinson M, "A global optimisation method for robust affine registration of brain images", Med Image Anal, 5, pp.143~156 (2001)
- Jenkinson M, "Improved optimization for the robust and accurate linear registration and motion correction of brain images", Neuroimage, 17, pp.825~841 (2002)
- Fischl B, "Whole brain segmentation : automated labeling of neuroanatomical structures in the human brain", Neuron, 33, pp.341~355 (2002)
- Avants BB, "The optimal template effect in hippocampus studies of diseased populations", Neuroimage, 49, pp.2457~2466 (2010)
- Avants BB, "A reproducible evaluation of ANTs similarity metric performance in brain image registration", Neuroimage, 54, pp.2033~2044 (2011)
- Smith SM, "Advances in functional and structural MR image analysis and implementation as FSL", Neuroimage, 23, pp.S208~S219 (2004)
- Wechsler D, "Wechsler Abbreviated Scale of Intelligence (WASI)" (1999), Psychological Corporation
- Wechsler D, "Wechsler Adult Intelligence Scale (WAIS-III)" (1997), Psychological Corporation
- Benton AL, "Multilingual Aphasia Examination (MAE)" (1994), Psychological Assessment Resources, Inc;
- Stern RA, "NAB, Neuropsychological Assessment Battery: Attention Module Stimulus Book. Form 2" (2003), Psychological Assessment Resources
- Cornblatt BA, "The Continuous Performance Test, identical pairs version (CPT-IP): I. New findings about sustained attention in normal families", Psychiatry Res, 26, pp.223~238 (1988)
- Mayer JD, "Mayer-Salovey-Caruso Emotional Intelligence Test (MSCEIT) Users Manual", Multi Health Systems, ~ (2002)
- Kay SR, "The positive and negative syndrome scale(PANSS)for schizophrenia", Schizophr Bull, 13, pp.261~276 (1987)
- Song SK, "Demyelination increases radial diffusivity in corpus callosum of mouse brain", Neuroimage, 26, pp.132~140 (2005)
- Song SK, "Dysmyelination revealed through MRI as increased radial(but unchanged axial)diffusion of water", Neuroimage, 17, pp.1429~1436 (2002)
- Alexander AL, "Characterization of cerebral white matter properties using quantitative magnetic resonance imaging stains", Brain Connect, 1, pp.423~446 (2011)
- Kochunov P, "Relationship between white matter fractional anisotropy and other indices of cerebral health in normal aging : tract-based spatial statistics study of aging", Neuroimage, 35, pp.478~487 (2007)
- Budde MD, "Axial diffusivity is the primary correlate of axonal injury in the experimental autoimmune encephalomyelitis spinal cord : a quantitative pixelwise analysis", J Neurosci, 29, pp.2805~2813 (2009)
- Levitt JJ, "Fractional anisotropy and radial diffusivity : diffusion measures of white matter abnormalities in the anterior limb of the internal capsule in schizophrenia", Schizophr Res, 136, pp.55~62 (2012)
- Shin YW, "Increased water diffusivity in the frontal and temporal cortices of schizophrenic patients", Neuroimage, 30, pp.1285~1291 (2006)
- Nenadic I, "Auditory hallucinations and brain structure in schizophrenia : voxel-based morphometric study", Br J Psychiatry, 196, pp.412~413 (2010)
- Knowles EE, "Processing speed deficits in schizophrenia : reexamining the evidence", Am J Psychiatry, 167, pp.828~835 (2010)
- Joyce EM, "Verbal fluency in schizophrenia : relationship with executive function, semantic memory and clinical alogia", Psychol Med, 26, pp.39~49 (1996)
- Nestor PG, "Neuropsychological disturbance in schizophrenia : a diffusion tensor imaging study", Neuropsychology, 22, pp.246~254 (2008)
- Szeszko PR, "Clinical and neuropsychological correlates of white matter abnormalities in recent onset schizophrenia", Neuropsychopharmacology, 33, pp.976~984 (2008)
- Leiderman EA, "Visuospatial deficits in schizophrenia : central executive and memory subsystems impairments", Schizophr Res, 68, pp.217~223 (2004)
- Cornblatt BA, "Impaired attention, genetics, and the pathophysiology of schizophrenia", Schizophr Bull, 20, pp.31~46 (1994)
- Eack SM, "Assessing social-cognitive deficits in schizophrenia with the Mayer-Salovey-Caruso Emotional Intelligence Test", Schizophr Bull, 36, pp.370~380 (2010)
- Klauser P, "White matter disruptions in schizophrenia are spatially widespread and topologically converge on brain network hubs", Schizophr Bull, 43, pp.425~435 (2017)
- Yendiki A, "Spurious group differences due to head motion in a diffusion MRI study", Neuroimage, 88, pp.79~90 (2014)
- Weinberger DR, "fMRI applications in schizophrenia research", Neuroimage, 4, pp.S118~S126 (1996)
- Yoo SS, "Head motion analysis during cognitive fMRI examination : application in patients with schizophrenia", Neurosci Res, 53, pp.84~90 (2005)
- Mayer AR, "Assessment and quantification of head motion in neuropsychiatric functional imaging research as applied to schizophrenia", J Int Neuropsychol Soc, 13, pp.839~845 (2007)
- Minami T, "Diffusion tensor magnetic resonance imaging of disruption of regional white matter in schizophrenia", Neuropsychobiology, 47, pp.141~145 (2003)
- Lieberman J, "Longitudinal study of brain morphology in first episode schizophrenia", Biol Psychiatry, 49, pp.487~499 (2001)
- Mathalon DH, "Progressive brain volume changes and the clinical course of schizophrenia in men : a longitudinal magnetic resonance imaging study", Arch Gen Psychiatry, 58, pp.148~157 (2001)
- Kubicki M, "Diffusion Tensor Imaging findings and their implications in schizophrenia", Curr Opin Psychiatry, 27, pp.179~184 (2014)
