본문 바로가기
KERD
논문KCI 등재

인삼양영탕을 이용한 실험연구 분석

Analysis of experimental studies on Insamyangyoung-tang

이혜원|최송이|김윤희
대한예방한의학회 (Society of Preventive Korean Medicine)|2015.08|대한예방한의학회지 (Society of Preventive Korean Medicine)|제19권 제2호|pp. 145-157

0

조회

0

다운로드

0

인용

0

참고문헌

키워드

Insamyangyoung-tang (Renshen yangrongninjin yoei to)pharmacological activityexperimental studytherapeutic events
주제분류한의학

초록

Objective : This study aimed to analyze a comprehensive feature of experimental research on Insamyangyoungtang and develop a strategy that can be used for experimental studies on Insamyangyoung-tang in the future. Method : The journal search was performed using six databases : PubMed, Chinese database (China Network Knowledge Infrastructure, [CNKI]), Japan database (Japan Science and Technology Information Aggregator, Electronic, [J-STAGE]) and three Korean databases (Oriental Medicine Advanced Searching Integrated System [OASIS], Research Information Service System [RISS], and Korean Studies Information Service System [KISS]). We used limited keywords and analyzed studies by publication year, experimental models, and the subjects of biological activities. The mechanism of pharmacological activity in accordance with the therapeutic effects of Insamyangyoung-tang was noted. Results and Conclusion : A total of 43 studies (6 domestic studies and 37 foreign ones) were examined according to the inclusion criteria of the experimental study. Research on the pharmacological activities of Insamyangyoung-tang showed its therapeutic effects on the nervous and immune systems, as well as its anti-aging, anti-fatigue, and hematopoietic effects. Additional efficacy and safety assessments and experimental and clinical studies should be performed to evaluate the mechanism of Insamyangyoung-tang. The present review has provided preliminary information for further studies on Insamyangyoung-tang.

Abstract

Objective : This study aimed to analyze a comprehensive feature of experimental research on Insamyangyoungtang and develop a strategy that can be used for experimental studies on Insamyangyoung-tang in the future. Method : The journal search was performed using six databases : PubMed, Chinese database (China Network Knowledge Infrastructure, [CNKI]), Japan database (Japan Science and Technology Information Aggregator, Electronic, [J-STAGE]) and three Korean databases (Oriental Medicine Advanced Searching Integrated System [OASIS], Research Information Service System [RISS], and Korean Studies Information Service System [KISS]). We used limited keywords and analyzed studies by publication year, experimental models, and the subjects of biological activities. The mechanism of pharmacological activity in accordance with the therapeutic effects of Insamyangyoung-tang was noted. Results and Conclusion : A total of 43 studies (6 domestic studies and 37 foreign ones) were examined according to the inclusion criteria of the experimental study. Research on the pharmacological activities of Insamyangyoung-tang showed its therapeutic effects on the nervous and immune systems, as well as its anti-aging, anti-fatigue, and hematopoietic effects. Additional efficacy and safety assessments and experimental and clinical studies should be performed to evaluate the mechanism of Insamyangyoung-tang. The present review has provided preliminary information for further studies on Insamyangyoung-tang.

참고문헌 (52)

  1. Ben-AIye E, "Attitudes of Arab and Jewish patientstowards integration of complernentary rnedicine in primary Care clinics in Israel;A cross culturalers study", soc Sci Med, 68, pp.177~182 (2009)
  2. Chua S, "Attitudes and beliefs towards complementary and a1temative medicine(CAM) : A cross-cultural approach comparing Singapore and the United Kingdom", Complerrentary Therapies in Medicine, 16(5), pp.247~252 (2008)
  3. 메디컬코리아교재연구회, "근거중심중의약 임상연구의 방법학", pp.270~285 (2011), 메디컬코리아
  4. 장영주, "人蔘養榮湯이 Aβ를 처리한 PC12 세포와 생쥐의 손상 뇌신경조직에 미치는 영향", 동의신경정신과학회지, 21(1), pp.109~124 (2010), 대한한방신경정신과학회
  5. 이용태, "人蔘養榮湯의 문헌고찰과 형상의학적 치료", 동의생리병리학회지, 19(4), pp.848~859 (2005), 한의병리학회
  6. 반혜란, "人蔘養榮湯 투여로 호전된 更年期障碍 15例에 대한 임상 고찰", 대한한방부인과학회지, 19(3), pp.257~266 (2006), 대한한방부인과학회
  7. Ogawa R, "Chronic fatigue syndrome--cases in the Kanebo Memorial Hospital", Nihon Rinsho, 50(11), pp.2648~2652 (1992)
  8. Nogami T, "A case of pulmonary Mycobacterium fortuitum infection successfully treated with Kampo treatments", Kekkaku, 81(8), pp.525~529 (2006)
  9. Yamasaki A, "Effect of Ninjin-yoei-to (Rensheng-Yangrong-Tang) on olfactory behavior after olfactory nerve transection", Phytomedicine, 15(5), pp.358~366 (2008)
  10. Seiwa C, "Restoration of FcRgamma", Fyn signaling repairs central nervous system demyelination, 2007, pp.85(5), 954~966
  11. Egashira N, "Ninjin-yoei-to (Ren-Shen-Yang-Rong-Tang) and Polygalae radix improves scopolamine-induced impairment of passive avoidance response in mice", Phytomedicine, 10(6-7), pp.467~473 (2003)
  12. Kobayashi J, "Effect of a traditional Chinese herbal medicine, Ren-Shen-Yang-Rong-Tang (Japanese name:Ninjin-Youei-To), on oligodendrocyte precursor cells from aged-rat brain", Int Immunopharmacol, 3(7), pp.1027~1039 (2003)
  13. Yabe T, "Induction of NGF synthesis in astrocytes by onjisaponins of Polygala tenuifolia, constituents of kampo (Japanese herbal)medicine, Ninjin-yoei-to", Phytomedicine, 10(2-3), pp.106~114 (2003)
  14. Tanaka K, "Therapeutic effect of a traditional Chinese medicine, ren-shenyang-rong-tang (Japanese name: Ninjin’yoeito)on nitric oxide-mediated lung injury in a mouse infected with murine cytomegalovirus", Int Immunopharmacol, 6(4), pp.678~685 (2006)
  15. Nakada T, "Effect of ninjin-youei-to on Th1", Th2 type cytokine production in different mouse strains, 2002, pp.30(2-3), 215~223
  16. Yin Y, "Ginseng Yangrong Soup’s Effect Study of Chemotherapy Drug s Causing Leucopenia", 26(11), pp.2055~2051 (2008)
  17. 은재순, "인삼양영탕이 생쥐의 특이적 면역반응에 미치는 영향", 동의생리병리학회지, 16(4), pp.18~733 (2002), 한의병리학회
  18. Abe S, "Protective effect of oral administration of several traditional Kampo-medicines on lethal Candida infection in immunosuppressed mice", Nihon Ishinkin Gakkai Zasshi, 41(2), pp.115~119 (2000)
  19. Luo J, "Immunoregulation Effect of Ginseng Tonic Decoction On Mice", China Journal of Modern Medicine, 12(5), pp.27~28 (2002)
  20. Ha J, "Experimental Studies on Antitumor and Immunomodulatory Effects of Insamyangyoungtang", J. of Oriental physiology and pathology, 12(1), pp.60~71 (1998)
  21. Nakai S, "Thymus-dependent effects of a traditional Chinese medicine, ren-shenyang-rong-tang (Japanese name; Ninjinyouei-to), in autoimmune MRI", MP-lpr, Int J Immunopharmacol, pp.1996, 18(4)[DOI]
  22. Harigai E, "Combined treatment with ren-shen-yangrong-tang (Japanese name: ninjin-youei-to)plus prednisolone on adjuvant-induced arthritis in Lewis rat", Int J Immunopharmacol, 17(5), pp.411~418 (1995)
  23. Zhou N, "Combined treatment of autoimmune MRL", MP-lpr, Int J Immunopharmacol, pp.1994, 16(10)[DOI]
  24. Nakai S, "Treatment effect of a traditional Chinese medicine, ren-shen-yangrong-tang (Japanese name: ninjin-youei-to), on autoimmune MRL", MP-lpr, Int J Immunopharmacol, pp.1993, 15(5)[DOI]
  25. Miura S, "Protective effect of ren-shen-yang-rong-tang (Ninjin-youeito)in mice with drug-induced leukopenia against Pseudomonas aeruginosa infection", Int J Immunopharmacol, 14(7), pp.1249~1257 (1992)
  26. Yonekura K, "Augmentation of host resistance to Listeria monocytogenes infection by a traditional Chinese medicine, ren-shen-yangrong-tang (Japanese name: ninjin-youei-to)", Immunopharmacol Immunotoxicol, 14(1-2), pp.165~190 (1992)
  27. Okamura S, "A traditional Chinese herbal medicine, ren-shen-yang-rong-tang (Japanese name: ninjin-yoei-to) augments the production of granulocyte-macrophage colonystimulating factor from human peripheral blood mononuclear cells in vitro", Int J Immunopharmacol, 13(5), pp.595~598 (1991)
  28. Deng H, "Protective effect of renshen yangron decoction on morphology and structure of mitochondria in brain and liver of subacute senile mice", Zhongguo Zhong Xi Yi Jie He Za Zhi, 26(Suppl), pp.33~35 (2006)
  29. Deng H, "Protective effect of renshen yangrong decoction on membrane fluidity of mitochondrion in brain and liver of subacute senile mice", Zhongguo Zhong Xi Yi Jie He Za Zhi, 26(Suppl), pp.30~33 (2006)
  30. Hu R, "Effect of Renshen Yangrong Decoction on Cerebral Neuron Form and Density in Aging M ice", Journal of Traditional Chinese Medicine, 47(11), pp.859~860 (2006)
  31. Uchiyama Y, "The effects of ninjinyoeito on human vascular endothelial cells", Am J Chin Med, 21(3-4), pp.279~289 (1993)
  32. Chen Y, "Anti-fatigue Effect of Renshen Yangrong Decotipn in Mice", Chinese Journal Of Integrative Medicine, 17(10), pp.770~774 (2011)
  33. Wnag M, "Effect of hypothalamusin malnutrition rats with chronic renal failure by adenine", Pharmacology and Clinics of Chinese Materia Medica, 27(2), pp.13~16 (2011)
  34. Wang Y, "The Effects of Renshen Yangrong decoction on Leptin Expression in Insulin-induced Rat Adipocytes", Journal of Mathematical Medicine, 24(1), pp.33~35 (2011)
  35. Chen Y, "Acute Toxicity and Anti-stress Effect of Ginseng Tonic Decoction in Mice", 1(8), pp.225~229 (2011)
  36. Takano F, "Oral Administration of Ren-Shen-Yang-Rong-Tang ‘Ninjin’-yoeito’ Protects Against Hematotoxicity and Induces Immature Erythroid Progenitor Cells in 5-Fluorouracil-induced Anemia", Evid Based Complement Alternat Med, 6(2), pp.247~256 (2009)
  37. Tang F, "Effect of “Renshen Yangrongtang” on Absorptive Function of Striated Border on Intestinal Mucosa of Aged Mice", Tianjin Medical Journal, 29(5), pp.297~299 (2001)
  38. 김승현, "人蔘養營湯의 산화적 stress에 대한 뇌세포 보호효과", 대한한방부인과학회지, 22(1), pp.1~14 (2009), 대한한방부인과학회
  39. Egashira T, "Changes of materials that scavenge 1,1-diphenyl-2-picrylhydrazyl radicals in plasma by per-oral administration of Kampo medicine, Ninjinyoei-to in rats", J Pharm Pharmacol, 55(3), pp.367~371 (2003)
  40. Takayama F, "Protective effect of Ninjin-yoei-to on damage to isolated hepatocytes following transient exposure to tert-butyl hydroperoxide", Jpn J Pharmacol, 85(3), pp.227~233 (2001)
  41. Aoki T, "Anti-inflammatory effect of a traditional Chinese medicine, ren-shen-yang-rong-tang (Japanese name:ninjin-youei-to), on alveolar macrophages stimulated by RANTES or TNF-alpha", Arerugi, 43(5), pp.663~667 (1994)
  42. Chen Y, "Protective effect of Renshen Yangrong Decoction (人参养荣汤) on bone marrow against radiation injury in mouse", Chin J Integr Med, 17(6), pp.453~458 (2011)
  43. Xu x, "The experiment study of Renshen Yangrong decoction on CRF rats of anaemia", Journal of Mathematical Medicine, 24(4), pp.465~467 (2011)
  44. 곽경규, "만성피로증후군의 한의학적 병태분석", 대한한방내과학회지, 29(4), pp.962~969 (2008), 대한한방내과학회
  45. Fujii Y, "Recipient-mediated effect of a traditional Chinese herbal medicine, renshen-yang-rong-tang (Japanese name: ninjinyouei-to), on hematopoietic recovery following lethal irradiation and syngeneic bone marrow transplantation", Int J Immunopharmacol, 16(8), pp.615~622 (1994)
  46. Ochi T, "Effects of Hochu-ekki-to and Ninjin-youei-to, traditional Japanese medicines, on porcine seruminduced liver fibrosis in rats", Immunopharmacol Immunotoxicol, 26(2), pp.285~298 (2004)
  47. Kobayashi T, "Preventive effect of Ninjin-to (Ren-Shen-Tang), a Kampo (Japanese traditional)formulation, on spontaneous autoimmune diabetes in non-obese diabetic (NOD) mice", Microbiol Immunol, 44(4), pp.299~305 (2000)
  48. Uchiyama Y, "The effect of ninjinyoeito on human aorta endothelial cells", Am J Chin Med, 22(3-4), pp.293~299 (1994)
  49. Miura S, "Effect of a traditional Chinese herbal medicine ren-shen-yang-rong-tang (Japanese name:ninjin-youei-to) on hematopoietic stem cells in mice", Int J Immunopharmacol, 11(7), pp.771~780 (1989)
  50. 곽남길, "人蔘養榮湯이 난소적출로 유발된 흰쥐의 골다공증 모델에 미치는 영향", 석사, 경락의과학과 해부학전공, pp.2013
  51. 송광규, "人蔘養榮湯이 비소세포 폐암세포 이식 마우스에서 항암, 면역활성 및 악액질 억제에 미치는 영향", 동의생리병리학회지, 27(1), pp.63~77 (2013), 한의병리학회
  52. 송광규, "암성 악액질(cancer cachexia)의 한약치료에 대한 고찰 -2000~2009년까지 중의논문을 중심으로-", 한국한의학연구원논문집, 16(2), pp.181~191 (2010), 한국한의학연구원

관련 논문AI추천

국내 십전대보탕 최근 연구 동향 분석고성규, 박선주, 박정수, 신용철, 오소미, 장보형, 장수빈, 전천후대한예방한의학회 · 대한예방한의학회지2014 · 제18권 제1호EBM 기반구축을 위한 사물탕 연구 문헌 분석김정훈, 서창섭, 신현규, 이남헌, 이준경, 이진아, 이호영, 정다영, 하혜경, 황대선한의병리학회 · 동의생리병리학회지2009 · 제23권 제4호加味人蔘養榮湯이 免疫反應 및 造血機能에 미치는 影響박경미, 유동열대한한방부인과학회 · 대한한방부인과학회지2004 · 제17권 제4호쌍화탕의 임상적 유효성 및 안전성: 문헌고찰김영철, 이은경, 이장훈대한한방내과학회 · 대한한방내과학회지2025 · 제46권 제4호EBM 기반구축을 위한 사군자탕 연구 문헌 정량 분석김정훈, 신현규, 이준경한의병리학회 · 동의생리병리학회지2010 · 제24권 제2호청심연자탕의 연구 동향안다영, 유준상, 한수지사상체질면역의학회 · 사상체질면역의학회지2018 · 제30권 제3호

이 간행물의 다른 논문 (14건)

국내 수도권 중⋅노년층의 한방건강증진행위 예측모형우원홍, 김수경, 최형욱pp. 1-12뇌성마비 아동의 한방 및 보완대체의료 이용 실태윤영주, 구현경, 김유림pp. 13-22우즈베키스탄 한방병원에서 진행한 한의약 비만관리 프로그램의 효과윤진원, 이은경, 유영진, 권동현, 이준석, 이선동, 박해모, 장보형, 고성규, 박유리, 정명수pp. 23-35한의의료비 자료원의 비교 분석 연구 : 조사 방법 및 2012년 한의원 의료비를 중심으로이은경, 고성규, 김동수, 정명수pp. 37-50진료 에피소드를 이용한 협진 의료이용 현황 분석 : 건강보험심사평가원 청구자료를 중심으로김남권, 엄태웅, 김신아pp. 51-56
원문 보기