Insomnia Disorder Among Coronavirus Disease Survivors: A South Korean Nationwide Cohort Study
2
조회
0
다운로드
3
인용
0
참고문헌
키워드
초록
Objective We investigated the prevalence and associated factors of insomnia disorder among survivors of coronavirus disease of 2019 (COVID-19).Methods This population-based cohort study used data from the National Health Insurance Service COVID-19 cohort database from January 1 to June 4, 2020. COVID-19 patients were defined as individuals whose test confirmed that they were infected, regardless of the severity, and survivors were defined as individuals who recovered from the infection.Results A total of 299,968 individuals were included in the final analysis, and 6,934 were considered as COVID-19 survivors, while the control group comprised 292,764 individuals. In the multivariable model after covariate adjustment, COVID-19 survivors had a 3.33-fold higher prevalence of insomnia disorder than the control group (odds ratio [OR]: 3.33, 95% confidence interval [CI]: 2.98–3.73; p<0.001). In the sensitivity analysis, the COVID-19 survivors with no specific treatment and the survivors with specific treatment were associated with a 3.16-fold (OR: 3.16, 95% CI: 2.77–3.59; p<0.001) and 3.89-fold (OR: 3.89, 95% CI: 3.17–4.78; p<0.001) higher prevalence of insomnia disorder than the control group.Conclusion In South Korea, 5.4% of COVID-19 survivors were diagnosed with insomnia disorder at 6 months follow-up. Thus, insomnia disorder is a public health issue for COVID-19 survivors.
Abstract
Objective We investigated the prevalence and associated factors of insomnia disorder among survivors of coronavirus disease of 2019 (COVID-19).Methods This population-based cohort study used data from the National Health Insurance Service COVID-19 cohort database from January 1 to June 4, 2020. COVID-19 patients were defined as individuals whose test confirmed that they were infected, regardless of the severity, and survivors were defined as individuals who recovered from the infection.Results A total of 299,968 individuals were included in the final analysis, and 6,934 were considered as COVID-19 survivors, while the control group comprised 292,764 individuals. In the multivariable model after covariate adjustment, COVID-19 survivors had a 3.33-fold higher prevalence of insomnia disorder than the control group (odds ratio [OR]: 3.33, 95% confidence interval [CI]: 2.98–3.73; p<0.001). In the sensitivity analysis, the COVID-19 survivors with no specific treatment and the survivors with specific treatment were associated with a 3.16-fold (OR: 3.16, 95% CI: 2.77–3.59; p<0.001) and 3.89-fold (OR: 3.89, 95% CI: 3.17–4.78; p<0.001) higher prevalence of insomnia disorder than the control group.Conclusion In South Korea, 5.4% of COVID-19 survivors were diagnosed with insomnia disorder at 6 months follow-up. Thus, insomnia disorder is a public health issue for COVID-19 survivors.
참고문헌 (39)
- Bedford J, "COVID-19 : towards controlling of a pandemic", Lancet, 395, pp.1015~1018 (2020)
- Dagan N, "BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Mass Vaccination Setting", N Engl J Med, 384, pp.1412~1423 (2021)
- Knoll MD, "Oxford-AstraZeneca COVID-19 vaccine efficacy", Lancet, 397, pp.72~74 (2021)
- "Dashboard by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University (JHU)" (2020)[URL]
- Garrigues E, "Post-discharge persistent symptoms and health-related quality of life after hospitalization for COVID-19", J Infect, 81, pp.e4~ (2020)
- Buysse DJ, "Insomnia", JAMA, 309, pp.706~716 (2013)
- Walsh JK, "Nighttime insomnia symptoms and perceived health in the America Insomnia Survey(AIS)", Sleep, 34, pp.997~1011 (2011)
- Chung Seockhoon, "The Prevalence and Incidence of Insomnia in Korea during 2005 to 2013", PSYCHIATRY INVESTIGATION, 17(6), pp.533~540 (2020), 대한신경정신의학회[DOI]
- Lin LY, "The immediate impact of the 2019 novel coronavirus(COVID-19)outbreak on subjective sleep status", Sleep Med, 77, pp.348~354 (2021)
- Kokou-Kpolou CK, "Insomnia during COVID-19 pandemic and lockdown : prevalence, severity, and associated risk factors in French population", Psychiatry Res, 290, pp.113128~ (2020)
- Sahin MK, "Prevalence of depression, anxiety, distress and insomnia and related factors in healthcare workers During COVID-19 pandemic in Turkey", J Community Health, 45, pp.1168~1177 (2020)
- Voitsidis P, "Insomnia during the COVID-19 pandemic in a Greek population", Psychiatry Res, 289, pp.113076~ (2020)
- von Elm E, "The Strengthening the Reporting of Observational Studies in Epidemiology(STROBE)statement : guidelines for reporting observational studies", Ann Intern Med, 147, pp.573~577 (2007)
- Dighe A, "Response to COVID-19 in South Korea and implications for lifting stringent interventions", BMC Med, 18, pp.321~ (2020)
- Khurshid KA, "Comorbid insomnia and psychiatric disorders : an update", Innov Clin Neurosci, 15, pp.28~32 (2018)
- Baum A, "Reduced in-person and increased telehealth outpatient visits during the COVID-19 pandemic", Ann Intern Med, 174, pp.129~131 (2021)
- Wosik J, "Impact of the COVID-19 pandemic on patterns of outpatient cardiovascular care", Am Heart J, 231, pp.1~5 (2021)
- Sjolander A, "On informative detection bias in screening studies", Stat Med, 27, pp.2635~2650 (2008)
- Mayer G, "Insomnia in central neurologic diseases--occurrence and management", Sleep Med Rev, 15, pp.369~378 (2011)
- Mohler H, "GABAA receptors in central nervous system disease : anxiety, epilepsy, and insomnia", J Recept Signal Transduct Res, 26, pp.731~740 (2006)
- Winkelman JW, "Reduced brain GABA in primary insomnia : preliminary data from 4T proton magnetic resonance spectroscopy(1H-MRS)", Sleep, 31, pp.1499~1506 (2008)
- Troyer EA, "Are we facing a crashing wave of neuropsychiatric sequelae of COVID-19? Neuropsychiatric symptoms and potential immunologic mechanisms", Brain Behav Immun, 87, pp.34~39 (2020)
- Zhou Z, "Understanding the neurotropic characteristics of SARS-CoV-2 : from neurological manifestations of COVID-19 to potential neurotropic mechanisms", J Neurol, 267, pp.2179~2184 (2020)
- Irwin MR, "Insomnia and inflammation : a two hit model of depression risk and prevention", World Psychiatry, 17, pp.359~361 (2018)
- Mullington JM, "Sleep loss and inflammation", Best Pract Res Clin Endocrinol Metab, 24, pp.775~784 (2010)
- Andenaes R, "Psychosocial factors are strongly associated with insomnia in users and nonusers of prescribed sleep medication : evidence from the HUNT3 study", J Multidiscip Healthc, 9, pp.547~555 (2016)
- Kalmbach DA, "The impact of stress on sleep : Pathogenic sleep reactivity as a vulnerability to insomnia and circadian disorders", J Sleep Res, 27, pp.e12710~ (2018)
- Moradi Y, "Psychological disturbances of survivors throughout COVID-19 crisis : a qualitative study", BMC Psychiatry, 20, pp.594~ (2020)
- Oh TK, "Risk of psychological sequelae among coronavirus disease-2019 survivors : a nationwide cohort study in South Korea", Depress Anxiety, 38, pp.247~254 (2021)
- 박혜윤, "Psychological Consequences of Survivors of COVID-19 Pneumonia 1 Month after Discharge", Journal of Korean Medical Science, 35(47), pp.1~5 (2020), 대한의학회[DOI]
- Taquet M, "Bidirectional associations between COVID-19 and psychiatric disorder : retrospective cohort studies of 62 354 COVID-19 cases in the USA", Lancet Psychiatry, 8, pp.130~140 (2021)
- Bagcchi S, "Stigma during the COVID-19 pandemic", Lancet Infect Dis, 20, pp.782~ (2020)
- Singh R, "COVID-19 and stigma : Social discrimination towards frontline healthcare providers and COVID-19 recovered patients in Nepal", Asian J Psychiatr, 53, pp.102222~ (2020)
- Dragano N, "Higher risk of COVID-19 hospitalization for unemployed : an analysis of 1, 298, 416 health insured individuals in Germany", Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz, 64, pp.314~321 (2021)
- Dooley D, "Depression and unemployment : panel findings from the Epidemiologic Catchment Area study", Am J Community Psychol, 22, pp.745~765 (1994)
- Geng F, "Bidirectional associations between insomnia, posttraumatic stress disorder, and depressive symptoms among adolescent earthquake survivors: a longitudinal multiwave cohort study", Sleep, 42, pp.zsz162~ (2019)
- Park HY, "Posttraumatic stress disorder and depression of survivors 12 months after the outbreak of Middle East respiratory syndrome in South Korea", BMC Public Health, 20, pp.605~ (2020)
- Martillo MA, "Postintensive care syndrome in survivors of critical illness related to coronavirus disease 2019 : Cohort study from a New York City critical care recovery clinic", Crit Care Med, 49, pp.1427~1438 (2021)
- Rawal G, "Post-intensive Care Syndrome : an Overview", J Transl Int Med, 5, pp.90~92 (2017)