Electroencephalographic Abnormalities in Clozapine-Treated Patients: A Cross-Sectional Study
0
조회
0
다운로드
2
인용
0
참고문헌
키워드
초록
The objective of our study was to examine the electroencephalogram (EEG) abnormalities associated with clozapine treatment. It was a cross-sectional study on 87 psychiatric patients on clozapine treatment. 32 channel digital EEG was recorded and analysed visually for abnormalities. EEG abnormalities were observed in 63.2% of patients. Both slowing and epileptiform activities were noted in 41.4% of patients. The EEG abnormalities were not associated with dose or duration of clozapine exposure.
Abstract
The objective of our study was to examine the electroencephalogram (EEG) abnormalities associated with clozapine treatment. It was a cross-sectional study on 87 psychiatric patients on clozapine treatment. 32 channel digital EEG was recorded and analysed visually for abnormalities. EEG abnormalities were observed in 63.2% of patients. Both slowing and epileptiform activities were noted in 41.4% of patients. The EEG abnormalities were not associated with dose or duration of clozapine exposure.
참고문헌 (46)
- Coward DM, "Biochemical and behavioural properties of clozapine", Psychopharmacology, 99, pp.S6~S12 (1989)
- van Tol HH, "Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine", Nature, 350, pp.610~614 (1991)
- Kane JM, "Psychopharmacologic treatment of schizophrenia", Schizophr Bull, 19, pp.287~302 (1993)
- Tamminga CA, "Clozapine in tardive dyskinesia: observations from human and animal model studies", J Clin Psychiatry, 55(B), pp.102~106 (1994)
- Alvir JM, "Clozapine-induced agranulocytosis. Incidence and risk factors in the United States", N Engl J Med, 329, pp.162~167 (1993)
- Devinsky O, "Seizures during clozapine therapy", J Clin Psychiatry, 55(B), pp.153~156 (1994)
- Haller E, "Clozapine and seizures", Am J Psychiatry, 147, pp.1069~1071 (1990)
- Pacia SV, "Clozapine-related seizures: experience with 5,629 patients", Neurology, 44, pp.2247~2249 (1994)
- Devinsky O, "Clozapine-related seizures", Neurology, 41, pp.369~371 (1991)
- Wilson WH, "Seizures associated with clozapine treatment in a state hospital", J Clin Psychiatry, 55, pp.184~188 (1994)
- Michals ML, "Clozapine response and adverse effects in nine brain-injured patients", J Clin Psychopharmacol, 13, pp.198~203 (1993)
- Baker RW, "Seizures during clozapine therapy", Am J Psychiatry, 148, pp.1265~1266 (1991)
- Thomas P, "Seizure with low doses of clozapine", Am J Psychiatry, 149, pp.138~139 (1992)
- Isermann H, "EEG-changes in paranoid-hallucinatory psychoses treated with Clozapine", Nervenarzt, 47, pp.268~ (1976)
- Spatz R, "The incidence of abnormal EEG patterns with clozapine therapy", Arzneimittelforschung, 28, pp.1499~1500 (1978)
- Naber D, "Clinical management of clozapine patients in relation to efficacy and side effects", Br J Psychiatry Suppl, 17, pp.54~59 (1992)
- Gunther W, "EEG alterations and seizures during treatment with clozapine. A retrospective study of 283 pa-tients", Pharmacopsychiatry, 26, pp.69~74 (1993)
- Welch J, "Clozapine-induced seizures and EEG changes", J Neuropsychiatry Clin Neurosci, 6, pp.250~256 (1994)
- Malow BA, "Spec-trum of EEG abnormalities during clozapine treatment", Electroencephalogr Clin Neurophysiol, 91, pp.205~211 (1994)
- Braun-Scharm H, "EEG changes and seizures with clozapine medication in schizophrenic adolescents", Z Kinder Jugendpsychiatr, 19, pp.164~169 (1991)
- Haring C, "EEG alterations in patients treated with clozapine in relation to plasma levels", Psychopharmacology, 114, pp.97~100 (1994)
- Freudenreich O, "Clozapine-induced electroencephalogram changes as a function of clozapine serum levels", Biol Psychiatry, 42, pp.132~137 (1997)
- Volavka J, "Hemispheric lateralization of fast EEG activity in schizophrenia and endogenous depression", Adv Biol Psychiatry, 6, pp.72~75 (1981)
- Treves IA, "EEG abnormalities in clozapine-treated schizophrenic patients", Eur Neuropsychopharmacol, 6, pp.93~94 (1996)
- Liukkonen J, "Clinical picture and long-term course of epileptic seizures that occur during clozapine treatment", Psychiatry Res, 44, pp.107~112 (1992)
- Lacroix D, "Quantified EEG changes associated with a positive clinical response to clozapine in schizophrenia", Prog Neuropsychopharmacol Biol Psychiatry, 19, pp.861~876 (1995)
- Praharaj SK, "Cloza-pine-induced myoclonus: a case study and brief review", Prog Neuropsychopharmacol Biol Psychiatry, 34, pp.242~243 (2010)
- Squires RF, "Clozapine and several other antipsychotic", antidepressant drugs preferentially block the same ‘core’ fraction of GABA(A) receptors, 1998, pp.23, 1283~1290
- Singhal SK, "Antipsychotic clozapine inhibits the function of alpha7-nicotinic acetylcholine receptors", Neuropharmacology, 52, pp.387~394 (2007)
- Arvanov VL, "Clozapine, but not haloperidol, prevents the functional hyperactivity of N-methyl-D-aspartate receptors in rat cortical neurons induced by subchronic administration of phencyclidine", J Pharmacol Exp Ther, 289, pp.1000~1006 (1999)
- Steward LJ, "The atypical antipsychotic drug clozapine enhances chronic PCP-induced regulation of prefrontal cortex 5-HT2A receptors", Neuropharmacology, 47, pp.527~537 (2004)
- Liu Y, "Clozapine inhibits st-rychnine-sensitive glycine receptors in rat hippocampal neurons", Brain Res, 1278, pp.27~33 (2009)
- Stevens JR, "Kindling with clozapine: behavioral and molecular consequences", Epilepsy Res, 26, pp.295~304 (1996)
- Wong J, "Clozapine-induced seizures: recognition and treatment", Can J Psychiatry, 52, pp.457~463 (2007)
- Risby ED, "Clozapine-induced EEG abnormalities and clinical response to clozapine", J Neuropsychiatry Clin Neurosci, 7, pp.466~470 (1995)
- Silvestri RC, "Clozapine-induced seizures and EEG abnormalities in ambulatory psychiatric patients", Ann Pharmacother, 32, pp.1147~1151 (1998)
- Greenwood-Smith C, "Serum clozapine levels: a review of their clinical utility", Psychopharmacol, 17, pp.234~238 (2003)
- Varma S, "Clozapine-related EEG changes and seizures: dose and plasma-level relationships", Ther Adv Psychopharmacol, 1, pp.47~66 (2011)
- Ng CH, "An inter-ethnic comparison study of clozapine dosage, clinical response and plasma levels", Int Clin Psychopharmacol, 20, pp.163~168 (2005)
- Lane HY, "Seizures after discontinuation of low-dose lorazepam from originally seizure-free clozapine regimen: combined effects", J Clin Psychiatry, 60, pp.408~409 (1999)
- Ravasia S, "Seizure on low-dose clozapine", Can J Psychiatry, 43, pp.420~ (1998)
- Amann BL, "EEG abnormalities associated with antipsychotics: a comparison of quetiapine, olanzapine, haloperidol and healthy subjects", Hum Psychopharmacol, 18, pp.641~646 (2003)
- Centorrino F, "EEG abnormalities during treatment with typical and atypical antipsychotics", Am J Psychiatry, 159, pp.109~115 (2002)
- Pillay SS, "EEG abnormalities before clozapine therapy predict a good clinical response to clozapine", Ann Clin Psychiatry, 8, pp.1~5 (1996)
- Knott V, "EEG hemispheric asymmetry as a predictor and correlate of short-term response to clozapine treatment in schizophrenia", Clin Electroencephalogr, 31, pp.145~152 (2000)
- Risby ED, "Clozapine-induced EEG abnormalities and clinical response to clozapine", J Neuropsychiatry Clin Neurosci, 7, pp.466~470 (1995)
