신증후군 환아에서 발생한 광범위한 뇌정맥 혈전증 1례
A Case of Extensive Cerebral Venous Thrombosis in Childhood Nephrotic Syndrome
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초록
저자들은 광범위한 뇌정맥 혈전증이 동반되었던 신증후군 환아에서 항응고 요법으로 치료하면서 신증후군의 관해와 함께 호전되었던 1례를 경험하고 치료하였기에 보고하는 바이다.
Abstract
Nephrotic syndrome in childhood is known to be associated with a hypercoagulable state and thromboembolic complications, among which cerebral venous thrombosis is a very rare and serious one, with only a few isolated reports in the literature. A 9-year-old boy with known nephrotic syndrome was admitted due to a relapse with massive proteinuria and generalized edema. He complained of a prolonged frontal headache. The enhanced brain magnetic resonance imaging(MRI) showed a high signal in the region of the superior sagittal sinus and right transverse sinus consistent with a thrombus. He was managed with steroids, cyclosporine and warfarin. His headache subsided 2 weeks later and proteinuria resolved 1 month later. An MRI 2 months later was normal. We describe this case and review the literature to emphasize the importance of recognizing this potentially life threatening complication and initiating anticoagulation therapy.
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