Orbito-Frontal Cortex Volumes in Panic Disorder
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Objective Given the association between the pathophysiology of panic disorder and prefrontal cortex function, we aimed to perform a volumetric MRI study in patients with panic disorder and healthy controls focusing on the in vivo neuroanatomy of the OFC. Methods Twenty right-handed patients with panic disorder and 20 right-handed healthy control subjects were studied. The volumes of whole brain, total white and gray matters, and OFC were measured by using T1-weighted coronal MRI images, with 1.5-mm-thick slices, at 1.5T. In addition, for psychological valuation, Hamilton Depression Rating (HDRS) and Panic Agoraphobia Scales (PAS) were administered. ResultsaaUnadjusted mean volumes of the whole brain volume, total white and gray matter were not different between the patients and healthy controls while the patient group had significantly smaller left (t=-6.70, p<0.0001) and right (t=-5.86, p<0.0001) OFC volumes compared with healthy controls. Conclusion Our findings indicate an alteration of OFC morphology in the panic disorder and suggest that OFC abnormalities may be involved in the pathophysiology of panic disorder.
Abstract
Objective Given the association between the pathophysiology of panic disorder and prefrontal cortex function, we aimed to perform a volumetric MRI study in patients with panic disorder and healthy controls focusing on the in vivo neuroanatomy of the OFC. Methods Twenty right-handed patients with panic disorder and 20 right-handed healthy control subjects were studied. The volumes of whole brain, total white and gray matters, and OFC were measured by using T1-weighted coronal MRI images, with 1.5-mm-thick slices, at 1.5T. In addition, for psychological valuation, Hamilton Depression Rating (HDRS) and Panic Agoraphobia Scales (PAS) were administered. ResultsaaUnadjusted mean volumes of the whole brain volume, total white and gray matter were not different between the patients and healthy controls while the patient group had significantly smaller left (t=-6.70, p<0.0001) and right (t=-5.86, p<0.0001) OFC volumes compared with healthy controls. Conclusion Our findings indicate an alteration of OFC morphology in the panic disorder and suggest that OFC abnormalities may be involved in the pathophysiology of panic disorder.
참고문헌 (37)
- American Psychiatry Association, "Diagnostic and Statistical Manual of Mental Disorders, 4th Edition" (1994), APA Press
- Kessler RC., "Prevalence, Severity, and Comorbidity of 12-Month DSM-IV Disorders in the National Comorbidity Survey Replication", Arch Gen Psychiatry, 62, pp.617~627 (2005)
- Fischer H., "Brain correlates of an unexpected panic attack: a human positron emission tomographic study", Neurosci Lett, 251, pp.137~140 (1998)
- Coplan JD., "Brain circuits in panic disorder", Biol Psychiatry, 44, pp.1264~1276 (1998)
- Pillay SS., "fMRI of fearful facial affect recognition in panic disorder: the cingulate gyrus-amygdala connection", J Affect Dis, 94, pp.173~181 (2006)
- Schunck T., "Functional magnetic resonance imaging characterization of CCK-4-induced panic attack and subsequent anticipatory anxiety", Neuroimage, 31, pp.1197~1208 (2006)
- Gorman M., "Neuroanatomical hypothesis of panic disorder, revised", Am J Psychiatry, 157, pp.493~505 (2000)
- Fontaine R., "Temporal lobe abnormalities in panic disorder: an MRI study", Biol Psychiatry, 27, pp.304~310 (1990)
- Vythilingam M., "Temporal lobe volume in panic disorder--a quantitative magnetic resonance imaging study", Psychiatry Res, 99, pp.75~82 (2000)
- Massana G., "Parahippocampal gray matter density in panic disorder: a voxel-based morphometric study", Am J Psychiatry, 160, pp.566~568 (2003)
- Massana G., "Amygdalar atrophy in panic disorder patients detected by volumetric magnetic resonance imaging", Neuroimage, 19, pp.80~90 (2003)
- Uchida RR., "Decreased left temporal lobe volume of panic patients measured by magnetic resonance imaging", Braz J Med Biol Res, 36, pp.925~929 (2003)
- Yoo HK., "Putaminal gray matter volume decrease in panic disorder: an optimized voxel-based morphometry study", Eur J Neurosci, 22, pp.2089~2094 (2005)
- Protopopescu X., "Increased brainstem volume in panic disorder: a voxel-based morphometric study", Neuroreport, 17, pp.361~363 (2006)
- Asami T., "Sexually dimorphic gray matter volume reduction in patients with panic disorder", Psychiatry Res Neuroimaging, 173, pp.128~134 (2009)
- Uchida RR., "Regional gray matter abnormalities in panic disorder: a voxel-based morphometry study", Psychiatry Res, 163, pp.21~29 (2008)
- Atmaca M., "Volumetric MRI study of key brain regions implicated in obsessive-compulsive disorder", Prog Neuropsychopharmacol Biol Psychiatry, 31, pp.46~52 (2007)
- Atmaca M., "Volumetric MRI assessment of brain regions in patients with refractory obsessive-compulsive disorder", Prog Neuropsychopharmacol Biol Psychiatry, 30, pp.1051~1057 (2006)
- Holland PC., "Amygdala-frontal interactions and reward expectancy", Curr Opin Neurobiol, 14, pp.148~155 (2004)
- Kalin NH., "Role of the primate orbitofrontal cortex in mediating anxious temperament", Biol Psychiatry, 62, pp.1134~1139 (2007)
- Kringelbach ML., "The human orbitofrontal cortex: linking reward to hedonic experience", Nat Rev Neurosci, 6, pp.691~702 (2005)
- Mellman TA., "Obsessive-compulsive symptoms in panic disorder", Am J Psychiatry, 144, pp.1573~1576 (1987)
- Karno M., "The epidemiology of obsessive-compulsive disorder in five US communities", Arch Gen Psychiatry, 45, pp.1094~1099 (1988)
- Austin LS., "Panic and phobic disorders in patients with obsessive compulsive disorder", J Clin Psychiatry, 51, pp.456~458 (1990)
- Rasmussen SA., "The epidemiology and differential diagnosis of obsessive-compulsive disorder", J Clin Psychiatry, 55, pp.5~10 (1994)
- Fava GA., "Obsessive-compulsive symptoms in agoraphobia: changes with treatment", Psychiatry Res, 23, pp.57~63 (1988)
- Hoffart A., "DSM-III-R Axis I and II disorders in agoraphobic patients with and without panic disorder", Acta Psychiatr Scand, 89, pp.186~191 (1994)
- Perugi G., "Depressive comorbidity of panic, social phobic, and obsessive-compulsive disorders re-examined: is there a bipolar II connection?", J Psychiatr Res, 33, pp.53~61 (1999)
- Goodwin R., "Obsessive-compulsive disorder and separation anxiety co-morbidity in early onset panic disorder", Psychol Med, 31, pp.1307~1310 (2001)
- Çrapçrıoğu A, "DSM-IV Eksen I Bozuklukları (SCID-I) İçn YapılandırılmışKlinik Göüşe, Klinik Versiyon" (1999), Hekimler Yayın Birliğ
- Bandelow B., "Assessing the efficacy of treatment for panic disorder and agoraphobia. II. The Panic and Agoraphobia Scale", Int Clin Psychopharmacol, 10, pp.73~81 (1995)
- Hamilton M., "Development of a rating scale for primary depressive illness", Br J Soc Clin Psychol, 6, pp.278~296 (1967)
- Yuh WTC., "MRI of Head & Neck Anatomy" (1994), Churchill Livingstone
- Jackson GD., "MRI Anatomy: A New Angle on the Brain" (1996), Churchill Livingstone
- Patel VH., "MRI of the Brain: Normal Anatomy and Normal Variants" (1997), WB Saunders Company
- Riffkin J., "A manual and automated MRI study of anterior cingulate and orbito-frontal cortices, and caudate nucleus in obsessive-compulsive disorder: comparison with healthy controls and patients with schizophrenia", Psychiatry Res, 138, pp.99~113 (2005)
- Roppongi T., "Posterior orbitofrontal sulcogyral pattern associated with orbitofrontal cortex volume reduction and anxiety trait in panic disorder", Psychiatry Clin Neurosci, 64, pp.318~326 (2010)