Disinfection of various materials with 3-(trimethoxysilyl)-propyldimethyloctadecyl ammonium chloride in hatchery facilities
1
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Objective: Surface disinfection is important in the proper running of livestock farms. However, disinfection of farm equipment and facilities is difficult because they are made of different materials, besides having large surface areas and complex structures. 3-(trimethoxysilyl)-propyldimethyloctadecyl ammonium chloride (Si-QAC) is a quaternary ammonium salt-based disinfectant that attaches to various surfaces by forming covalent bonds and maintains its disinfecting capacity for a considerable time. Our aim was to evaluate the potential use of Si-QAC for disinfection of farm equipment and facilities. Methods: The short- and long-term antimicrobial and antiviral effects of Si-QAC were evaluated in both laboratory and farm settings using modified quantitative assessment method based on the standard operating procedures of the United States Environmental Protection Agency. Results: Si-QAC was highly effective in controlling the growth of the Newcastle disease virus and avian pathogenic Escherichia coli. Electron microscopy revealed that the mechanism underlying the disinfection activity of Si-QAC was associated with its ability to damage the outer membrane of the pathogen cells. In the field test, Si-QAC effectively reduced viral contamination of surfaces of equipment and space. Conclusion: Our results suggest that Si-QAC has great potential as an effective chemical for disinfecting farm equipment and facilities. This disinfectant could retain its disinfection ability longer than other commercial disinfectants and contribute to better farm biosecurity.
Abstract
Objective: Surface disinfection is important in the proper running of livestock farms. However, disinfection of farm equipment and facilities is difficult because they are made of different materials, besides having large surface areas and complex structures. 3-(trimethoxysilyl)-propyldimethyloctadecyl ammonium chloride (Si-QAC) is a quaternary ammonium salt-based disinfectant that attaches to various surfaces by forming covalent bonds and maintains its disinfecting capacity for a considerable time. Our aim was to evaluate the potential use of Si-QAC for disinfection of farm equipment and facilities. Methods: The short- and long-term antimicrobial and antiviral effects of Si-QAC were evaluated in both laboratory and farm settings using modified quantitative assessment method based on the standard operating procedures of the United States Environmental Protection Agency. Results: Si-QAC was highly effective in controlling the growth of the Newcastle disease virus and avian pathogenic Escherichia coli. Electron microscopy revealed that the mechanism underlying the disinfection activity of Si-QAC was associated with its ability to damage the outer membrane of the pathogen cells. In the field test, Si-QAC effectively reduced viral contamination of surfaces of equipment and space. Conclusion: Our results suggest that Si-QAC has great potential as an effective chemical for disinfecting farm equipment and facilities. This disinfectant could retain its disinfection ability longer than other commercial disinfectants and contribute to better farm biosecurity.
참고문헌 (20)
- "OIE-WAHIS: Analystics: quantitative data" (2021)[URL]
- HPAI epidemiological investigation report 2017-2018, "Park BG", Animal and Plant, Quarantine Agency, ~, pp.Report No.: 11-1543061-000330-01 (2018)
- Guinat C, "Biosecurity risk factors for highly pathogenic avian influenza(H5N8)virus infection in duck farms, France", Transbound Emerg Dis, 67, pp.2961~2970 (2020)[DOI]
- Ortí-Lucas RM, "Effectiveness of surface coatings containing silver ions in bacterial decontamination in a recovery unit", Antimicrob Resist Infect Control, 6, pp.61~ (2017)[DOI]
- Champagne VK, "A demonstration of the antimicrobial effectiveness of various copper surfaces", J Biol Eng, 7, pp.8~ (2013)[DOI]
- Chua PH, "Surface functionalization of titanium with hyaluronic acid", chitosan polyelectrolyte multilayers and RGD for promoting osteoblast functions and inhibiting bacterial adhesion, 2008, pp.29, 1412~1421
- Lagemaat MVD, "Comparison of methods to evaluate bacterial contact-killing materials", Acta Biomater, 59, pp.139~147 (2017)[DOI]
- Isquith AJ, "Surface-bonded antimicrobial activity of an organosilicon quaternary ammonium chloride", Appl Microbiol, 24, pp.859~863 (1972)[DOI]
- Green JD, "Immobilized antimicrobial agents : a critical perspective", Chem Rev, 109, pp.5437~5527 (2009)
- Caballero B, "Encyclopedia of food sciences and nutrition", pp.1382~1385 (2003), Elsevier Academic Press
- Tseng CC, "Application of a quaternary ammonium agent on surgical face masks before use for predecontamination of nosocomial infection-related bioaerosols", Aerosol Sci Technol, 50, pp.199~210 (2016)[DOI]
- Tomšič B, "Characterisation and functional properties of antimicrobial bio-barriers formed by natural fibres", Colloids Surf B Biointerfaces, 122, pp.72~78 (2014)[DOI]
- Nikawa H, "Immobilization of octadecyl ammonium chloride on the surface of titanium and its effect on microbial colonization in vitro", Dent Mater J, 24, pp.570~582 (2005)[DOI]
- Gottenbos B, "In vitro and in vivo antimicrobial activity of covalently coupled quaternary ammonium silane coatings on silicone rubber", Biomaterials, 23, pp.1417~1423 (2002)[DOI]
- West AM, "Strain, disinfectant, concentration, and contact time quantitatively impact disinfectant efficacy", Antimicrob Resist Infect Control, 7, pp.49~ (2018)[DOI]
- Ivanova EP, "Bactericidal activity of black silicon", Nat Commun, 4, pp.2838~ (2013)[DOI]
- Porosa L, "Detection and antimicrobial activity of immobilized quaternary ammonium antimicrobial monolayers on porous and non-porous surfaces", pp.2014
- Lewis K, "Surpassing nature : rational design of sterile-surface materials", Trends Biotechnol, 23, pp.343~348 (2005)[DOI]
- Murata H, "Permanent, non-leaching antibacterial surfaces—2 : How high density cationic surfaces kill bacterial cells", Biomaterials, 28, pp.4870~4879 (2007)[DOI]
- Siddiqui WH, "Percutaneous absorption of an antimicrobial organosilicon quarternary ammonium chloride in rabbits", J Appl Toxicol, 3, pp.146~149 (1983)[DOI]