Times to Discontinue Antidepressants Over 6 Months in Patients with Major Depressive Disorder
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ObjectiveaaThe aim of the present study was to investigate differences in discontinuation time among antidepressants and total antidepressant discontinuation rate of patients with depression over a 6 month period in a naturalistic treatment setting. MethodsaaWe reviewed the medical records of 900 patients with major depressive disorder who were initially prescribed only one kind of antidepressant. The prescribed antidepressants and the reasons for discontinuation were surveyed at baseline and every 4 weeks during the 24 week study. We investigated the discontinuation rate and the mean time to discontinuation among six antidepressants groups. ResultsaaMean and median overall discontinuation times were 13.8 and 12 weeks, respectively. Sertraline and escitalopram had longer discontinuation times than that of fluoxetine, and patients who used sertraline discontinued use significantly later than those taking mirtazapine. No differences in discontinuation rate were observed after 24 weeks among these antidepressants. About 73% of patients discontinued antidepressant treatment after 24 weeks. ConclusionaaSertraline and escitalopram tended to have longer mean times to discontinuation, although no difference in discontinuation rate was detected between antidepressants after 24 weeks. About three-quarters of patients discontinued antidepressant maintenance therapy after 24 weeks.
Abstract
ObjectiveaaThe aim of the present study was to investigate differences in discontinuation time among antidepressants and total antidepressant discontinuation rate of patients with depression over a 6 month period in a naturalistic treatment setting. MethodsaaWe reviewed the medical records of 900 patients with major depressive disorder who were initially prescribed only one kind of antidepressant. The prescribed antidepressants and the reasons for discontinuation were surveyed at baseline and every 4 weeks during the 24 week study. We investigated the discontinuation rate and the mean time to discontinuation among six antidepressants groups. ResultsaaMean and median overall discontinuation times were 13.8 and 12 weeks, respectively. Sertraline and escitalopram had longer discontinuation times than that of fluoxetine, and patients who used sertraline discontinued use significantly later than those taking mirtazapine. No differences in discontinuation rate were observed after 24 weeks among these antidepressants. About 73% of patients discontinued antidepressant treatment after 24 weeks. ConclusionaaSertraline and escitalopram tended to have longer mean times to discontinuation, although no difference in discontinuation rate was detected between antidepressants after 24 weeks. About three-quarters of patients discontinued antidepressant maintenance therapy after 24 weeks.
참고문헌 (35)
- Kessler RC, "Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication", Arch Gen Psychiatry, 62, pp.593~602 (2005)
- Kessler RC, "The epidemiology of major depressive disorder : results from the National Comorbidity Survey Replication(NCS-R)", JAMA, 289, pp.3095~3105 (2003)
- Wells KB, "The functioning and well-being of depressed patients. Results from the Medical Outcomes Study", JAMA, 262, pp.914~919 (1989)
- Murray CJ, "Evidence-based health policy--lessons from the Global Burden of Disease Study", Science, 274, pp.740~743 (1996)
- Greenberg PE, "The economic burden of depression in 1990", J Clin Psychiatry, 54, pp.405~418 (1993)
- Hales RE, "The American Psychiatric Publishing Textbook of Clinical Psychiatry" (2003), American Psychiatric Pub
- Solomon DA, "Continuation and maintenance pharmacotherapy for unipolar and bipolar mood disorders", Psychiatr Clin North Am, 16, pp.515~540 (1993)
- American Psychiatric Association, "Practice Guideline for Major Depressive Disorder in Adults", American Psychiatric Association, ~ (1993)
- Lam RW, "Canadian Network for Mood and Anxiety Treatments (CANMAT) clinical guidelines for the management of major depressive disorder in adults. III. Pharmacotherapy", J Affect Disord, 117(Suppl 1), pp.S26~S43 (2009)
- Demyttenaere K, "Adherence to treatment regimen in depressed patients treated with amitriptyline or fluoxetine", J Affect Disord, 65, pp.243~252 (2001)
- Lin EH, "The role of the primary care physician in patients’ adherence to antidepressant therapy", Med Care, 33, pp.67~74 (1995)
- Katon W, "Adequacy and duration of antidepressant treatment in primary care", Med Care, 30, pp.67~76 (1992)
- Demyttenaere K, "Compliance in depressed patients treated with fluoxetine or amitriptyline. Belgian Compliance Study Group", Int Clin Psychopharmacol, 13, pp.11~17 (1998)
- Ascher-Svanum H, "Time to discontinuation of atypical versus typical antipsychotics in the naturalistic treatment of schizophrenia", BMC Psychiatry, 6, pp.8~ (2006)
- Kroken RA, "Time to discontinuation of antipsychotic drugs in a schizophrenia cohort : influence of current treatment strategies", Ther Adv Psychopharmacol, 4, pp.228~239 (2014)
- Kreyenbuhl J, "Time to discontinuation of first-and second-generation antipsychotic medications in the treatment of schizophrenia", Schizophr Res, 131, pp.127~132 (2011)
- Lee YM, "Time to discontinuation among the three second-generation antidepressants in a naturalistic outpatient setting of depression", Psychiatry Clin Neurosci, 65, pp.630~637 (2011)
- 이경욱, "항우울제를 복용 중인 주요 우울증 환자에서 조기 치료 중단율과 위험 요인", 대한정신약물학회지, 17(6), pp.550~556 (2006), 대한정신약물학회
- Simon G, "Cost-effectiveness comparisons using"real world"randomized trials : the case of new antidepressant drugs", J Clin Epidemiol, 48, pp.363~373 (1995)
- 함병주, "외적 환경을 고려한 최적의 항우울제 치료", 신경정신의학, 47(1), pp.22~27 (2008), 대한신경정신의학회
- 배경열, "Antidepressant Prescribing Patterns in Korea: Results from the Clinical Research Center for Depression Study", PSYCHIATRY INVESTIGATION, 8(3), pp.234~244 (2011), 대한신경정신의학회
- Spineli LM, "The impact of trial characteristics on premature discontinuation of antipsychotics in schizophrenia", Eur Neuropsychopharmacol, 23, pp.1010~1016 (2013)
- Hansen HV, "Adherence to antidepressant treatment", Expert Rev Neurother, 7, pp.57~62 (2007)
- Lee MS, "Variables influencing antidepressant medication adherence for treating outpatients with depressive disorders", J Affect Disord, 123, pp.216~221 (2010)
- Wu CS, "Persistence of antidepressant treatment for depressive disorder in Taiwan", Gen Hosp Psychiatry, 35, pp.279~285 (2013)
- Sawada N, "Persistence and compliance to antidepressant treatment in patients with depression : a chart review", BMC Psychiatry, 9, pp.38~ (2009)
- Geddes JR, "Relapse prevention with antidepressant drug treatment in depressive disorders : a systematic review", Lancet, 361, pp.653~661 (2003)
- Cipriani A, "Comparative efficacy and acceptability of 12 new-generation antidepressants : a multiple-treatments meta-analysis", Lancet, 373, pp.746~758 (2009)
- Mullins CD, "Persistence, switching, and discontinuation rates among patients receiving sertraline, paroxetine, and citalopram", Pharmacotherapy, 25, pp.660~667 (2005)
- Poluzzi E, "Trend in SSRI-SNRI antidepressants prescription over a 6-year period and predictors of poor adherence", Eur J Clin Pharmacol, 69, pp.2095~2101 (2013)
- Esposito D, "Results of a retrospective claims database analysis of differences in antidepressant treatment persistence associated with escitalopram and other selective serotonin reuptake inhibitors in the United States", Clin Ther, 31, pp.644~656 (2009)
- Gartlehner G, "Discontinuation rates for selective serotonin reuptake inhibitors and other second-generation antidepressants in outpatients with major depressive disorder : a systematic review and meta-analysis", Int Clin Psychopharmacol, 20, pp.59~69 (2005)
- Kirino E, "Escitalopram for the management of major depressive disorder:a review of its efficacy, safety, and patient acceptability", Patient Prefer Adherence, 6, pp.853~861 (2012)
- Burra TA, "Predictors of self-reported antidepressant adherence", Behav Med, 32, pp.127~134 (2007)
- Vanelli M, "Role of patient experience in antidepressant adherence : a retrospective data analysis", Clin Ther, 30, pp.1737~1745 (2008)