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시스템생물학의 한의학적 응용

Application of Systems Biology to Traditional Korean Medicine

이선동|박영철
대한예방한의학회 (Society of Preventive Korean Medicine)|2016.04|대한예방한의학회지 (Society of Preventive Korean Medicine)|제20권 제1호|pp. 99-110

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키워드

Korean traditional medicinesSystems biologyHolismOmics
주제분류한의학

초록

In Korea and China, traditional medicine’s holistic approaches, based on the views of whole-body and whole-person, have been applied to make the solution of health problem. However, these holistic approaches of traditional korea or chinese medicine have been limited in interpreting their theories in a view of modern scientific aspects of medicine. This limitation seems to be mainly due to the reductionism approaches of modern scientific medicine. Traditionally, science has taken a reductionism approach; dissecting biological systems into their constituent parts and studying them in isolation. However, systems biology based on omics technologies is providing a new thought and method for traditional medicine’s research and interpretation. Systems biology uses integrity study as the characteristic and bioinformatic technology as the key method for connecting reductionism and holism. Therefore, it has much in common with the theory of traditional medicine. It was reviewed that how systems biology is applied to traditional medicine in Korea and China. Also it was suggested that more future researches on interpretation between traditional medicine and systems biology must be focused on personalized medicine since systems biology will have a major impact on future personalized therapeutic approaches.

Abstract

In Korea and China, traditional medicine’s holistic approaches, based on the views of whole-body and whole-person, have been applied to make the solution of health problem. However, these holistic approaches of traditional korea or chinese medicine have been limited in interpreting their theories in a view of modern scientific aspects of medicine. This limitation seems to be mainly due to the reductionism approaches of modern scientific medicine. Traditionally, science has taken a reductionism approach; dissecting biological systems into their constituent parts and studying them in isolation. However, systems biology based on omics technologies is providing a new thought and method for traditional medicine’s research and interpretation. Systems biology uses integrity study as the characteristic and bioinformatic technology as the key method for connecting reductionism and holism. Therefore, it has much in common with the theory of traditional medicine. It was reviewed that how systems biology is applied to traditional medicine in Korea and China. Also it was suggested that more future researches on interpretation between traditional medicine and systems biology must be focused on personalized medicine since systems biology will have a major impact on future personalized therapeutic approaches.

참고문헌 (65)

  1. Liu X, "Pharmacological tools for the development of traditional Chinese medicine", Trends in Pharmacological Sciences, 34(11), pp.620~628 (2013)
  2. Li Q, "Artesunate : The Best Drug in the Treatment of Severe and Complicated Malaria", Pharmaceuticals, 3(7), pp.2322~2332 (2010)
  3. Tu YY, "Studies on the constituents of Artemisia annua L", Acta Pharm. Sin, 16, pp.366~370 (1981)
  4. Anon, "Marketing of new drug from Tianjing TASLY Pharma", Monthly Information on Traditional Chinese Medicine, 15, pp.0304~1502 (2003)
  5. Li YG, "Advancement in analysis of Salviae miltiorrhizae Radix et Rhizoma (Danshen)", J. Chromatogr. A, 1216(11), pp.1941~1953 (2009)
  6. Zhang A, "Future perspectives of personalized medicine in traditional Chinese medicine: A systems biology approach", Complementary Therapies in Medicine, 20, pp.93~99 (2012)
  7. Cheng F, "Biologic basis of TCM syndromes and the standardization of syndrome classification", Journal of Traditional Chinese Medical Sciences, 1, pp.92~97 (2014)
  8. 손인철, "한의학에서의 생명관", 원불교사상과 종교문화, (45), pp.119~162 (2010), 원불교사상연구원
  9. 백유상, "韓醫學 정체성 논의에 대한 연구 - 原典學을 중심으로", 대한한의학원전학회지, 23(5), pp.123~132 (2010), 대한한의학원전학회
  10. 정지연, "한의학의 과학적 연구를 위한 대사체학(Metabolomics)에 대한 고찰", Korean Journal of Acupuncture, 25(4), pp.147~166 (2008), 경락경혈학회
  11. Science Times, "한의학, 증거에 기반하는 학문돼야", ~ (2009)
  12. Crick F, "Central dogma of molecular biology", Nature, 227(5258), pp.561~563 (1970)
  13. Kandal R, "The era of ‘omics unlimited", Biotechniques, 46, pp.351~355 (2009)
  14. Snoep JL, "Systems Biology: Definitions and Perspectives", Topics in Current Genetics, 13, pp.13~30 (2004), Springer-Verlag
  15. Chen L, "Biomolecular Networks: Methods and Applications in Systems Biology" (2009), John Wiley & Sons
  16. "Guest Editor’s Introduction. Systems biology with omics data", Methods, 67, pp.267~268 (2014)
  17. Liu X, "Pharmacological tools for the development of traditional Chinese medicine", Trends in Pharmacological Sciences, 34(11), pp.620~628 (2013)
  18. Li S, "Traditional Chinese medicine network pharmacology: theory, methodology and application", Chinese Journal of Natural Medicines, 11(2), pp.0110~0120 (2013)
  19. 조광현, "시스템생물학: 생체네트워크의 동역학에대한 새로운 고찰", 전기의 세계, 59(3), pp.27~31 (2010)
  20. "Information theory in systems biology. Part II: protein–proteininteraction and signaling networks", Seminars in Cell & Developmental Biology (2015)
  21. Iglesias RA, "Systems biology: the role of engineering in the reverse engineeringof biological signaling", Cells, 2(2), pp.393~413 (2013)
  22. 이민영, "생물시스템의 네트워크모델링과 시스템즈 생물학", 제어⋅자동화⋅시스템공학회지, 11(3), pp.34~37 (2005)
  23. "WHO International Standard Terminologieson Traditional Medicine in The Western Pacific Region" (2007)[URL]
  24. 이태규, "一個 綜合病院 健康檢診者의 四象體質에 따른 慢性疾患의 有病率에 關한 硏究", 사상체질의학회지, 17(2), pp.32~45 (2005), 사상체질의학회
  25. Robinson SW, "Current advances in systems and integrative biology", Computational and Structural Biotechnology Journal, 11, pp.35~46 (2014)
  26. Wei S, "Genotyping and quantification techniques for singlenucleotide polym orphism s", Trends in Analytical Chemistry, 69, pp.1~13 (2015)
  27. Giacomini KM, "When good drugs go bad", Nature, 446(7139), pp.975~977 (2007)
  28. Hedrick P, "Genetics of Populations", pp.104~ (2014), Jones &Bartlett Learning
  29. 이수경, "사상체질의 Cholecystokinin 유전자 단일염기다형성 연구", 대한한의학회지, 25(3), pp.105~110 (2004), 대한한의학회
  30. 송일병, "사상체질의 유전적 다형성 연구- MTHFR의 단일염기다형성을 중심으로 –", 사상체질의학회지, 13(2), pp.177~181 (2001)
  31. Cha SW, "Genetic Effects of FTO and MC4R Polymorphisms on Body Mass in Constitutional Types", Evidence-Based Complementary and Alternative Medicine, pp.1~7 (2011)
  32. "위키백과-한증 및 열증"[URL]
  33. 김진호, "八綱辨證에 대한 비교 연구 - 張介賓·程國彭·江涵暾을 중심으로 -", 대한한의학원전학회지, 26(2), pp.47~59 (2013), 대한한의학원전학회
  34. 김성훈, "상한 온병의 팔강변증(八綱辨證)분류체계에 관한 연구", 대전대학교 한의학연구소논문집, 6(2), pp.351~381 (1998)
  35. Li S, "Understanding ZHENG in traditional Chinese medicine in the context of neuroendocrine-immune network", IET Systems Biology, 1(1), pp.51~60 (2007)
  36. "ONIM 데이터베이스"[URL]
  37. McGettigan PA, "Transcriptomics in the RNAseq era Paul A McGettigan", Current Opinion in Chemical Biology, 17, pp.4~11 (2013)
  38. Yan SK, "“Omics” in pharmaceutical research: overview, applications, challenges, and future perspectives", Chinese Journal of Natural Medicines, 13(1), pp.3~21 (2015)
  39. Chawla A, "Nuclear receptors and lipid physiology:opening the X-files", Science, 294, pp.1866~1870 (2001)
  40. Benoit G, "International Union of Pharmacology. LXVI. Orphan nuclear receptors", Pharmacol. Rev, 58, pp.798~836 (2006)
  41. Li L, "Botanical compounds and their regulation of nuclear receptor action : The case of traditional Chinese medicine", Molecular and Cellular Endocrinology, 401, pp.221~237 (2015)
  42. Sladek FM, "What are nuclear receptor ligands?", Mol. Cell. Endocrinol, 334, pp.3~13 (2010)
  43. Gao J, "Targeting xenobiotic receptors PXR and CAR for metabolic diseases", Trends Pharmacol. Sci, 33, pp.552~558 (2012)
  44. Pearen MA, "Minireview: nuclear hormone receptor 4A signaling: implications for metabolic disease", Mol. Endocrinol, 24, pp.1891~1903 (2010)
  45. Calkin AC, "Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR", Nat. Rev. Mol. Cell Biol, 13, pp.213~224 (2012)
  46. Urizar NL, "A natural product that lowers cholesterol as an antagonist ligand for FXR", Science, 296, pp.1703~1706 (2002)
  47. James P, "Protein identification in the postgenome era: the rapid rise of proteomics", Quarterly reviews of biophysics, 30(4), pp.279~331 (1997)
  48. 주현, "프로테오믹스 : 단백질에 대한 이해및 기능 해석의 새로운 접근과 응용" (2004), 범문사
  49. Zhang A, "An in vivo analysis of the therapeutic and synergistic properties of Chinese medicinal formula Yin-Chen- Hao-Tang based on its active constituents", Fitoterapia, 82, pp.1160~1168 (2011)
  50. Sun H, "Proteomics study on the hepatoprotective effects of traditional Chinese medicineformulae Yin-Chen-Hao-Tang by a combination of two-dimensional polyacrylamide gel electrophoresis and matrix-assisted laser desorption", ionization-time of flight mass spectrometry, 2013, pp.75, 173~179
  51. Nicholson JK, "Global systems biology, personalized medicine and molecular epidemiology", Mol. Syst. Biol, 2(1), pp.52~ (2006)
  52. Jordan KW, "Metabolomic Characterization of Human Rectal Adenocarcinoma with Intact Tissue Magnetic Resonance Spectroscopy", Diseases of the Colon & Rectum, 52(3), pp.520~525 (2009)
  53. Kraly JR, "Review : Microfluidic applications in metabolomics and metabolic profiling", Analytica Chimica Acta, 653, pp.23~35 (2009)
  54. Naz S, "Method validation strategies involved in non-targeted metabolomics", Journal of Chromatography A, 1353, pp.99~105 (2014)
  55. 김소현, "대사체학의 연구 동향, 응용 및 국내 연구 활성화 방안", KSBB Journal, 24(2), pp.113~121 (2009), 한국생물공학회
  56. Gerdes S, "Comorbidities and psoriasis. Impact on clinical practice", Hautarzt, 63(3), pp.202~213 (2012)
  57. Lu C, "Application of metabolomics on diagnosis and treatment of patients with psoriasis in traditional Chinese medicine", Biochimica et Biophysica Acta, 1844, pp.280~288 (2014)
  58. "A Glimpse Into Personalized Medicine of the Future" (2009)[URL]
  59. Owen K. Davis, "Personalized medicine or “one size fits all?”", Fertility and Sterility, 101(4), pp.922~923 (2013)
  60. "1000 Genomes. A deep catalog of human genetic variation"[URL]
  61. Genomes Project Committee, "A map of human genome variation from population-scale sequencing", Nature, 467, pp.1061~1073 (2010)
  62. Genomes Project Committee, "An integrated map of genetic variation from 1,092 human genomes", Nature, 491, pp.56~65 (2012)
  63. Bartfai T, "Personalized medicine", pp.231~248 (2013), The Future of Drug Discovery
  64. 권순일, "맞춤의학시대를 열어갈 질환관련 SNP 연구의 최근 동향", 한국전문대학교육연구학회논문집, 10(1), pp.59~67 (2009)
  65. 의약품의 글로벌 개발⋅평가 동향, "식품의약품안전평가원", ~, pp.행정간행물번호: 11-1470550-000286-01 (2012)

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