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논문KCI 등재

소아의 신성 고혈압

Renal and Renovascular Hypertension in Children

한혜원
대한소아신장학회 (The Korean Society Of Pediatric Nephrology)|2011.04|Childhood Kidney Diseases (Childhood Kidney diseases)|제15권 제1호|pp. 1-13

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참고문헌

키워드

ChildrenAdolescentRenovascular hypertensionRenal hypertenion
주제분류소아과학

초록

Hypertension is a major risk factor of atherosclerosis which results in cardiovascular disease, and remains a major health problem worldwide. While children are more likely to have secondary hypertension, recent studies support the theory that the prevalence of essential hypertension in children and adolescents is increasing with the global epidemic of childhood obesity, and close attention is needed. Evaluation of hypertension in the pediatric age group should be guided by the age at presentation, and renal diseases must be considered in every child with hypertension, because of the prevalence of renovascular and renal parenchymal disorders as the etiology in any age group. The majority of children with chronic kidney disease are hypertensive, and many have associated end organ damage. Thus, once hypertension has been confirmed, end organ care as well as pharmacologic therapy must be continued. In renovascular hypertension, as cure could be gained with surgical/endovascular intervention, accurate diagnosis is important and it is recommended that every suspected child should undergo angiography.

Abstract

Hypertension is a major risk factor of atherosclerosis which results in cardiovascular disease, and remains a major health problem worldwide. While children are more likely to have secondary hypertension, recent studies support the theory that the prevalence of essential hypertension in children and adolescents is increasing with the global epidemic of childhood obesity, and close attention is needed. Evaluation of hypertension in the pediatric age group should be guided by the age at presentation, and renal diseases must be considered in every child with hypertension, because of the prevalence of renovascular and renal parenchymal disorders as the etiology in any age group. The majority of children with chronic kidney disease are hypertensive, and many have associated end organ damage. Thus, once hypertension has been confirmed, end organ care as well as pharmacologic therapy must be continued. In renovascular hypertension, as cure could be gained with surgical/endovascular intervention, accurate diagnosis is important and it is recommended that every suspected child should undergo angiography.

참고문헌 (82)

  1. "The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents", Pediatrics, 114(2 Suppl 4th Report), pp.555~576 (2004)
  2. Londe S, "Causes of hypertension in the young", Pediatr Clin North Am, 25, pp.55~65 (1978)
  3. Din-Dzietham R, "High blood pressure trends in children and adolescents in national surveys, 1963 to 2002", Circulation, 116, pp.1488~1496 (2007)
  4. Flynn JT, "Pediatric hypertension update", Curr Opin Nephrol Hypertens, 19, pp.292~297 (2010)
  5. Feber J, "Hypertension in children: new trends and challenges", Clin Sci (Lond), 119, pp.151~161 (2010)
  6. Chiolero A, "Has blood pressure increased in children in response to the obesity epidemic", Pediatrics, 119, pp.544~553 (2007)
  7. Flynn JT, "Hypertension in the young: epidemiology, sequelae and therapy", Nephrol Dial Transplant, 24, pp.370~375 (2009)
  8. Assadi F, "Relation of left ventricular hypertrophy to microalbuminuria and C-reactive protein in children and adolescents with essential hypertension", Pediatr Cardiol, 29, pp.580~584 (2008)
  9. Lubrano R, "Blood pressure load, proteinuria and renal function in pre-hypertensive children", Pediatr Nephrol, 24, pp.823~831 (2009)
  10. Feld LG, "Hypertension in children", Curr Probl Pediatr, 18, pp.317~373 (1988)
  11. Rames LK, "Normal blood pressure and the evaluation of sustained blood pressure elevation in childhood: the Muscatine study", Pediatrics, 61, pp.245~251 (1978)
  12. Tullus K, "Renovascular hypertension in children", Lancet, 371, pp.1453~1463 (2008)
  13. Stadermann MB, "Results of surgical treatment for renovascular hypertension in children: 30 year single centre experience", Nephrol Dial Transplant, 25, pp.807~813 (2010)
  14. Baumgartner I, "Renovascular hypertension: screening and modern management", Eur Heart J
  15. Plouin PF, "Fibromuscular dysplasia", Orphanet J Rare Dis, 2, pp.28~ (2007)
  16. Ingelfinger JR, "Spectrum of renal anomalies in patients with Williams syndrome", J Pediatr, 119, pp.771~773 (1991)
  17. Deal JE, "Renovascular disease in childhood", J Pediatr, 121, pp.378~384 (1992)
  18. Slovut DP, "Fibromuscular dysplasia", N Engl J Med, 29(350), pp.1862~1871 (2004)
  19. D'Souza SJ, "Diagnosis and management of stenotic aorto-arteriopathy in childhood", J Pediatr, 132, pp.1016~1022 (1998)
  20. Deal JE, "Phaeochromocytoma--investigationand management of 10 cases", Arch Dis Child, 65, pp.269~274 (1990)
  21. Koskimies O, "Arterial hypertension developing 10 years after radiotherapy for Wilms's tumour", Br Med J (Clin Res Ed), 285, pp.996~998 (1982)
  22. Sozen H, "Renal transplantation in children", Transplant Proc, 통권 : 38, pp.426~429 (2006)
  23. Han M, "Renal artery stenosis and aneurysms associated with neurofibromatosis", J Vasc Surg, 41, pp.539~543 (2005)
  24. Nystrom HC, "Neurohormonal influences on maintenance and reversal of two-kidney one-clip renal hypertension", Acta Physiol Scand, 175, pp.245~251 (2002)
  25. Higashi Y, "Endothelial function and oxidative stress in renovascular hypertension", N Engl J Med, 346, pp.1954~1962 (2002)
  26. Tullus K, "Imaging in the evaluation of renovascular disease", Pediatr Nephrol, 25, pp.1049~1056 (2010)
  27. Brun P, "Value of Doppler ultrasound for the diagnosis of renal artery stenosis in children", Pediatr Nephrol, 11, pp.27~30 (1997)
  28. Gao J, "Intrarenal color duplex ultrasonography: a window to vascular complications of renal transplants", J Ultrasound Med, 26, pp.1403~1418 (2007)
  29. Dellegrottaglie S, "Technology Insight: magnetic resonance angiography for the evaluation of patients with peripheral artery disease", Nat Clin Pract Cardiovasc Med, 4, pp.677~687 (2007)
  30. Vo NJ, "Anatomic distribution of renal artery stenosis in children: implications for imaging", Pediatr Radiol, 36, pp.1032~1036 (2006)
  31. Wong H, "Management of severe hypertension in a child with tuberous sclerosis- related major vascular abnormalities", J Hypertens, 24, pp.597~599 (2006)
  32. Konig K, "Treatment of severe renal artery stenosis by percutaneous transluminal renal angioplasty and stent implantation: review of the pediatric experience: apropos of two cases", Pediatr Nephrol, 21, pp.663~671 (2006)
  33. Hughes RJ, "Renal angioplasty in non-atheromatous renal artery stenosis: technical results and clinical outcome in 43 patients", Cardiovasc Intervent Radiol, 27, pp.435~440 (2004)
  34. Watson AR, "Renovascular hypertension in childhood: a changing perspective in management", J Pediatr, 106, pp.366~372 (1985)
  35. Tyagi S, "Percutaneous transluminal angioplasty for renovascular hypertension in children: initial and long-term results", Pediatrics, 99, pp.44~49 (1997)
  36. Ing FF, "Arterial stents in the management of neurofibromatosis and renovascular hypertension in a pediatric patient: case report of a new treatment modality", Cardiovasc Intervent Radiol, 18, pp.414~418 (1995)
  37. Imamura H, "Successful stenting of bilateral renal artery stenosis due to fibromuscular dysplasia assessed by use of pressure guidewire technique: a case report", Angiology, 49, pp.69~74 (1998)
  38. McLaren CA, "Interventional radiology for renovascular hypertension in children", Tech Vasc Interv Radiol, 6, pp.150~157 (2003)
  39. Stanley JC, "Pediatric renovascular hypertension: a thirty-year experience of operative treatment", J Vasc Surg, 21, pp.212~226 (1995)
  40. McTaggart SJ, "Evaluation and long-term outcome of pediatric renovascular hypertension", Pediatr Nephrol, 14, pp.1022~1029 (2000)
  41. Trinquart L, "Efficacy of revascularization for renal artery stenosis caused by fibromuscular dysplasia: a systematic review and meta-analysis", Hypertension, 56, pp.525~532 (2010)
  42. Arar MY, "Etiology of sustained hypertension in children in the southwestern United States", Pediatr Nephrol, 8, pp.186~189 (1994)
  43. Simoes e Silva AC, "Risk of hypertension in primary vesicoureteral reflux", Pediatr Nephrol, 22, pp.459~462 (2007)
  44. Warnock DG, "Liddle syndrome: genetics and mechanisms of Na+ channel defects", Am J Med Sci, 322, pp.302~307 (2001)
  45. Dillon MJ, "Reflux nephropathy", J Am Soc Nephrol, 9, pp.2377~2383 (1998)
  46. Gordon I, "Vesico-ureteric reflux, urinary- tract infection, and renal damage in children", Lancet, 346, pp.489~490 (1995)
  47. Flynn JT, "Blood pressure in children with chronic kidney disease: a report from the Chronic Kidney Disease in Children study", Hypertension, 52, pp.631~637 (2008)
  48. Groothoff JW, "Long-term outcomes of children with end-stage renal disease", Pediatr Nephrol, 20, pp.849~853 (2005)
  49. Griendling KK, "Molecular biology of the renin-angiotensin system", Circulation, 87, pp.1816~1828 (1993)
  50. Muller DN, "The renin-angiotensin system in the vessel wall", Basic Res Cardiol, 93(Suppl 2), pp.7~14 (1998)
  51. Hadtstein C, "Hypertension in children with chronic kidney disease: pathophysiology and management", Pediatr Nephrol, 23, pp.363~371 (2008)
  52. Wolf G, "The renin- angiotensin system and progression of renal disease: from hemodynamics to cell biology", Nephron Physiol, 93, pp.P3~P13 (2003)
  53. Williams GH, "Aldosterone biosynthesis, regulation, and classical mechanism of action", Heart Fail Rev, 10, pp.7~13 (2005)
  54. Savoia C, "Selective mineralocorticoid receptor blocker eplerenone reduces resistance artery stiffness in hypertensive patients", Hypertension, 51, pp.432~439 (2008)
  55. Susic D, "Long-term mineralocorticoid receptor blockade reduces fibrosis and improves cardiac performance and coronary hemodynamics in elderly SHR", pp.H175~H179 (2007), Am J Physiol Heart Circ Physiol
  56. Alvarez-Lara MA, "Blood pressure and body water distribution in chronic renal failure patients", Nephrol Dial Transplant, 16(Suppl 1), pp.94~97 (2001)
  57. Weidmann P, "Pathogenesis of hypertension associated with chronic renal failure", Contrib Nephrol, 41, pp.47~65 (1984)
  58. Dubinion JH, "Role of renal sympathetic nerves in regulating renovascular responses to angiotensin II in spontaneously hypertensive rats", J Pharmacol Exp Ther, 317, pp.1330~1336 (2006)
  59. Campese VM, "Neurogenic factors in renal hypertension", Curr Hypertens Rep, 4, pp.256~260 (2002)
  60. Boero R, "Sympathetic nervous system and chronic renal failure", Clin Exp Hypertens, 23, pp.69~75 (2001)
  61. Miyajima E, "Muscle sympathetic nerve activity in renovascular hypertension and primary aldosteronism", Hypertension, 17, pp.1057~1062 (1991)
  62. Carlini RG, "Recombinant human erythropoietin stimulates angiogenesis in vitro", Kidney Int, 47, pp.740~745 (1995)
  63. Vaziri ND, "Mechanism of erythropoietin- induced hypertension", Am J Kidney Dis, 33, pp.821~828 (1999)
  64. Sato A, "Glucocorticoid increases angiotensin II type 1 receptor and its gene expression", Hypertension, 23, pp.25~30 (1994)
  65. Krakoff L, "Pathogenesis of hypertension in Cushing's syndrome", Am J Med, 58, pp.216~220 (1975)
  66. Scherrer U, "Cyclosporine- induced sympathetic activation and hypertension after heart transplantation", N Engl J Med, 323, pp.693~699 (1990)
  67. Busauschina A, "Cyclosporine nephrotoxicity", Transplant Proc, 36, pp.229S~233S (2004)
  68. Johannsson G, "GH increases extracellular volume by stimulating sodium reabsorption in the distal nephron and preventing pressure natriuresis", J Clin Endocrinol Metab, 87, pp.1743~1749 (2002)
  69. Charra B, "Blood pressure control in dialysis patients: importance of the lag phenomenon", Am J Kidney Dis, 32, pp.720~724 (1998)
  70. Bartosh SM, "Childhood hypertension. An update on etiology, diagnosis, and treatment", Pediatr Clin North Am, 46, pp.235~252 (1999)
  71. Woroniecki RP, "How are hypertensive children evaluated and managed? A survey of North American pediatric nephrologists", Pediatr Nephrol, 20, pp.791~797 (2005)
  72. Ligtenberg G, "Reduction of sympathetic hyperactivity by enalapril in patients with chronic renal failure", N Engl J Med, 340, pp.1321~1328 (1999)
  73. Nakao N, "Combination treatment of angiotensin-II receptor blocker and angiotensin-converting-enzymeinhibitor in non-diabetic renal disease (COOPERATE): a randomised controlled trial", Lancet, 361, pp.117~124 (2003)
  74. Campbell R, "Effects of combined ACE inhibitor and angiotensin II antagonist treatment in human chronic nephropathies", Kidney Int, 63, pp.1094~1103 (2003)
  75. Lubrano R, "Renal and cardiovascular effects of angiotensin-converting enzyme inhibitor plus angiotensin II receptor antagonist therapy in children with proteinuria", Pediatrics, 118, pp.e833~e838 (2006)
  76. Sahney S, "A review of calcium channel antagonists in the treatment of pediatric hypertension", Paediatr Drugs, 8, pp.357~373 (2006)
  77. Krum H, "Efficacy of eplerenone added to renin-angiotensin blockade in hypertensive patients", Hypertension, 40, pp.117~123 (2002)
  78. Pitt B, "Eplerenone reduces mortality 30 days after randomization following acute myocardial infarction in patients with left ventricular systolic dysfunction and heart failure", J Am Coll Cardiol, 46, pp.425~431 (2005)
  79. Nussberger J, "Angiotensin II suppression in humans by the orally active renin inhibitor Aliskiren (SPP100): comparison with enalapril", Hypertension, 39, pp.E1~E8 (2002)
  80. Stanton A, "Blood pressure lowering in essential hypertension with an oral renin inhibitor, aliskiren", Hypertension, 42, pp.1137~1143 (2003)
  81. Krum H, "Catheter- based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study", Lancet, 373, pp.1275~1281 (2009)
  82. Paulis L, "Novel therapeutic targets for hypertension", Nat Rev Cardiol, 7, pp.431~441 (2010)

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