Depression and APOEε4 Status in Individuals with Subjective Cognitive Decline: A Meta-Analysis
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Objective To evaluate the associative role of depression and apolipoprotein E epsilon 4 allele (APOEε4) in subjective cognitive decline (SCD) and its progression to objective cognitive decline.Methods After literature search in electronic databases, studies were selected by following precise eligibility criteria. Meta-analyses were performed to examine the role of APOEε4 and depression in SCD or its progression to mild cognitive impairment (MCI) or dementia.Results APOEε4 positivity was not different between SCD and normal individuals but was significantly higher in individuals with SCD plus than in normal individuals [odds ratio: 2.39 (95% CI: 1.87, 3.05); p<0.00001] and in SCD converters than in non-converters [odds ratio: 5.19 (95% CI: 2.36, 11.42); p<0.00001]. Depression was significantly higher in individuals with SCD [standardized mean difference: 0.63 (0.45, 0.82); p<0.00001] and SCD plus [standardized mean difference: 0.83 (0.43, 1.22); p<0.0001] than in normal individuals. However, depression was not different between SCD and MCI or between SCD converters and non-converters. Age of SCD converters was higher than non-converters [mean difference: 2.95 years (0.58, 5.31)].Conclusion Whereas APOEε4 positivity was higher in SCD plus and SCD converters, depression was higher in SCD and SCD plus but was not different between SCD and MCI.
Abstract
Objective To evaluate the associative role of depression and apolipoprotein E epsilon 4 allele (APOEε4) in subjective cognitive decline (SCD) and its progression to objective cognitive decline.Methods After literature search in electronic databases, studies were selected by following precise eligibility criteria. Meta-analyses were performed to examine the role of APOEε4 and depression in SCD or its progression to mild cognitive impairment (MCI) or dementia.Results APOEε4 positivity was not different between SCD and normal individuals but was significantly higher in individuals with SCD plus than in normal individuals [odds ratio: 2.39 (95% CI: 1.87, 3.05); p<0.00001] and in SCD converters than in non-converters [odds ratio: 5.19 (95% CI: 2.36, 11.42); p<0.00001]. Depression was significantly higher in individuals with SCD [standardized mean difference: 0.63 (0.45, 0.82); p<0.00001] and SCD plus [standardized mean difference: 0.83 (0.43, 1.22); p<0.0001] than in normal individuals. However, depression was not different between SCD and MCI or between SCD converters and non-converters. Age of SCD converters was higher than non-converters [mean difference: 2.95 years (0.58, 5.31)].Conclusion Whereas APOEε4 positivity was higher in SCD plus and SCD converters, depression was higher in SCD and SCD plus but was not different between SCD and MCI.
참고문헌 (53)
- Jessen F, "A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer’s disease", Alzheimers Dement, 10, pp.844~852 (2014)
- Lee MJ, "Memory and confusion complaints in visually impaired older adults : an understudied aspect of well-being", Gerontol Geriatr Med, 5, pp.2333721418818944~ (2019)
- Dufouil C, "Subjective cognitive complaints and cognitive decline : consequence or predictor? The epidemiology of vascular aging study", J Am Geriatr Soc, 53, pp.616~621 (2005)
- Reisberg B, "Outcome over seven years of healthy adults with and without subjective cognitive impairment", Alzheimers Dement, 6, pp.11~24 (2010)
- Mitchell AJ, "Risk of dementia and mild cognitive impairment in older people with subjective memory complaints : meta-analysis", Acta Psychiatr Scand, 130, pp.439~451 (2014)
- Gifford KA, "The source of cognitive complaints predicts diagnostic conversion differentially among nondemented older adults", Alzheimers Dement, 10, pp.319~327 (2014)
- de Groot JC, "Cerebral white matter lesions and subjective cognitive dysfunction : the Rotterdam Scan Study", Neurology, 56, pp.1539~1545 (2001)
- Verfaillie SC, "Thinner temporal and parietal cortex is related to incident clinical progression to dementia in patients with subjective cognitive decline", Alzheimers Dement(Amst), 5, pp.43~52 (2016)
- Snitz BE, "Amyloid-beta imaging in older adults presenting to a memory clinic with subjective cognitive decline : a pilot study", J Alzheimers Dis, 48(Suppl 1), pp.S151~S159 (2015)
- Hanninen T, "Subjective memory complaints and personality traits in normal elderly subjects", J Am Geriatr Soc, 42, pp.1~4 (1994)
- Cooper C, "The meaning of reporting forgetfulness : a cross-sectional study of adults in the English 2007 Adult Psychiatric Morbidity Survey", Age Ageing, 40, pp.711~717 (2011)
- Balash Y, "Subjective memory complaints in elders: depression, anxiety, or cognitive decline?", Acta Neurol Scand, 127, pp.344~350 (2013)
- Bessi V, "The implication of BDNF Val66Met polymorphism in progression from subjective cognitive decline to mild cognitive impairment and Alzheimer’s disease : a 9-year follow-up study", Eur Arch Psychiatry Clin Neurosci, 270, pp.471~482 (2020)
- Buckley RF, "Subjective memory decline predicts greater rates of clinical progression in preclinical Alzheimer’s disease", Alzheimers Dement, 12, pp.796~804 (2016)
- Caselli RJ, "Subjective cognitive decline : self and informant comparisons", Alzheimers Dement, 10, pp.93~98 (2014)
- Choe YM, "Subjective memory complaint as a useful tool for the early detection of Alzheimer’s disease", Neuropsychiatr Dis Treat, 14, pp.2451~2460 (2018)
- Chu CS, "The association between subjective memory complaint and objective cognitive function in older people with previous major depression", PLoS One, 12, pp.e0173027~ (2017)
- Dik MG, "Memory complaints and APOE-epsilon4 accelerate cognitive decline in cognitively normal elderly", Neurology, 57, pp.2217~2222 (2001)
- Fernandez-Blazquez MA, "Specific features of subjective cognitive decline predict faster conversion to mild cognitive impairment", J Alzheimers Dis, 52, pp.271~281 (2016)
- Grambaite R, "Correlates of subjective and mild cognitive impairment : depressive symptoms and CSF biomarkers", Dement Geriatr Cogn Dis Extra, 3, pp.291~300 (2013)
- Hong YJ, "Predictors of clinical progression of subjective memory impairment in elderly subjects : data from the Clinical Research Centers for Dementia of South Korea(CREDOS)", Dement Geriatr Cogn Disord, 40, pp.158~165 (2015)
- Jessen F, "Patterns of subjective memory impairment in the elderly : association with memory performance", Psychol Med, 37, pp.1753~1762 (2007)
- Jessen F, "Prediction of dementia by subjective memory impairment : effects of severity and temporal association with cognitive impairment", Arch Gen Psychiatry, 67, pp.414~422 (2010)
- Jessen F, "AD dementia risk in late MCI, in early MCI, and in subjective memory impairment", Alzheimers Dement, 10, pp.76~83 (2014)
- Jorm AF, "Memory complaints in a community sample aged 60-64 years : associations with cognitive functioning, psychiatric symptoms, medical conditions, APOE genotype, hippocampus and amygdala volumes, and white-matter hyperintensities", Psychol Med, 34, pp.1495~1506 (2004)
- Kim JM, "Subjective memory impairment, cognitive function and depression--a community study in older Koreans", Dement Geriatr Cogn Disord, 15, pp.218~225 (2003)
- Merrill DA, "Modifiable risk factors and brain positron emission tomography measures of amyloid and tau in nondemented adults with memory complaints", Am J Geriatr Psychiatry, 24, pp.729~737 (2016)
- Miebach L, "Which features of subjective cognitive decline are related to amyloid pathology? Findings from the DELCODE study", Alzheimers Res Ther, 11, pp.66~ (2019)
- Muller-Gerards D, "Subjective cognitive decline, APOE epsilon4, and incident mild cognitive impairment in men and women", Alzheimers Dement(Amst), 11, pp.221~230 (2019)
- Niti M, "APOE-epsilon4, depressive symptoms, and cognitive decline in Chinese older adults : Singapore Longitudinal Aging Studies", J Gerontol A Biol Sci Med Sci, 64, pp.306~311 (2009)
- Risacher SL, "APOE effect on Alzheimer’s disease biomarkers in older adults with significant memory concern", Alzheimers Dement, 11, pp.1417~1429 (2015)
- Roehr S, "Incident subjective cognitive decline does not predict mortality in the elderly--Results from the Longitudinal German Study on Ageing, Cognition, and Dementia(AgeCoDe)", PLoS One, 11, pp.e0147050~ (2016)
- Sanchez-Benavides G, "Brain and cognitive correlates of subjective cognitive decline-plus features in a population-based cohort", Alzheimers Res Ther, 10, pp.123~ (2018)
- Scheef L, "Subregional volume reduction of the cholinergic forebrain in subjective cognitive decline(SCD)", Neuroimage Clin, 21, pp.101612~ (2019)
- Sohrabi HR, "The relationship between memory complaints, perceived quality of life and mental health in apolipoprotein Eepsilon4 carriers and noncarriers", J Alzheimers Dis, 17, pp.69~79 (2009)
- Slot RER, "Subjective Cognitive Impairment Cohort(SCIENCe) : study design and first results", Alzheimers Res Ther, 10, pp.76~ (2018)
- Stewart R, "Depression, APOE genotype and subjective memory impairment : a crosssectional study in an African-Caribbean population", Psychol Med, 31, pp.431~440 (2001)
- Striepens N, "Interaction effects of subjective memory impairment and ApoE4 genotype on episodic memory and hippocampal volume", Psychol Med, 41, pp.1997~2006 (2011)
- Visser PJ, "Prevalence and prognostic value of CSF markers of Alzheimer’s disease pathology in patients with subjective cognitive impairment or mild cognitive impairment in the DESCRIPA study : a prospective cohort study", Lancet Neurol, 8, pp.619~627 (2009)
- Wang L, "Subjective memory deterioration and future dementia in people aged 65 and older", J Am Geriatr Soc, 52, pp.2045~2051 (2004)
- Weisenbach SL, "Depression and cognitive impairment in older adults", Curr Psychiatry Rep, 14, pp.280~288 (2012)
- Lockwood KA, "Executive dysfunction in geriatric depression", Am J Psychiatry, 159, pp.1119~1126 (2002)
- Butters MA, "The nature and determinants of neuropsychological functioning in late-life depression", Arch Gen Psychiatry, 61, pp.587~595 (2004)
- Kohler S, "The pattern and course of cognitive impairment in late-life depression", Psychol Med, 40, pp.591~602 (2010)
- Hill NL, "Subjective cognitive impairment and affective symptoms : a systematic review", Gerontologist, 56, pp.e109~e127 (2016)
- Liew TM, "Depression, subjective cognitive decline, and the risk of neurocognitive disorders", Alzheimers Res Ther, 11, pp.70~ (2019)
- Skoog I, "A 9-year prospective population-based study on the association between the APOE*E4 allele and late-life depression in Sweden", Biol Psychiatry, 78, pp.730~736 (2015)
- Wang WW, "Depression was associated with apolipoprotein E ε4 allele polymorphism : a meta-analysis", Iran J Basic Med Sci, 22, pp.112~117 (2019)
- Burke SL, "Associations between depression, sleep disturbance, and apolipoprotein E in the development of Alzheimer’s disease : dementia", Int Psychogeriatr, 28, pp.1409~1424 (2016)
- Zhang T, "Apolipoprotein E e4 Allele is associated with subjective cognitive decline : a meta-analysis", Neuroepidemiology, 49, pp.165~173 (2017)
- Xu J, "Neurobiological substrates underlying the effect of genomic risk for depression on the conversion of amnestic mild cognitive impairment", Brain, 141, pp.3457~3471 (2018)
- Rawle MJ, "Apolipoprotein-E(Apoe)ε4 and cognitive decline over the adult life course", Transl Psychiatry, 8, pp.18~ (2018)
- Jiang Q, "ApoE promotes the proteolytic degradation of Abeta", Neuron, 58, pp.681~693 (2008)
