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야뇨증의 병인 기전 –항이뇨호르몬, 고칼슘뇨증, 용질성 이뇨

Circadian Rhythm of ADH, Hypercalciuria, and Solute Diuresis as Pathogenesis of Enuresis

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참고문헌

키워드

주제분류소아과학

초록

야간 다뇨는 야뇨증의 중요한 원인 중 하나로 거론된다. 소변 양을 조절하는 항이뇨호르몬의 일중 변동의 부적절한 조절, 고칼슘뇨증, 용질 이뇨가 야간 다뇨의 원인으로 생각되며, 이러한 기전들로 야간의 소변량이 많은 환자에서 방광용적이 상대적으로 작고 잠에서 깨어나기 어려운 경우 야뇨증이 발생한다. 야뇨증 환자에서 이러한 요인들을 평가하여 개개인에게 적절한 치료를 도입하여야 할 것이다.

Abstract

Nocturnal polyuria is one of the main pathogenic mechanisms of enuresis. Disturbance of circadian rhythm of antidiuretic hormone (ADH or AVP), hypercalciuria, and/or solute diuresis are considered to cause nocturnal polyuria, which in turn causes enuresis in patients with relatively small bladder capacity and high threshold for awakening. Evaluation of these factors would guide the therapeutic approach for enuresis.

참고문헌 (42)

  1. Lundgren R, "Nocturia: a new perspective on an old symptom", Scandinavian Journal of Urology and Nephrology, 38, pp.112~116 (2004)
  2. Bottomley G, "Treating nocturnal enuresis in children in primary care", The Practitioner, 255, pp.23~26 (2011)
  3. Bower WF, "The epide-miology of childhood enuresis in Australia", British Journal of Urology, 78, pp.602~606 (1996)
  4. Robson WL, "Clinical practice. Evaluation and management of enuresis", The New England Journal of Medicine, 360, pp.1429~1436 (2009)
  5. Norgaard JP, "Diurnal anti-diuretic- hormone levels in enuretics", The Journal of Urology, 134, pp.1029~1031 (1985)
  6. Vande Walle J, "Nocturnal polyuria is related to 24-hour diuresis and osmotic excretion in an enuresis population referred to a tertiary center", The Journal of Urology, 178, pp.2630~2634 (2007)
  7. Chung JM, "Evaluation of bladder capacity in Korean children younger than 24 months: a nationwide multicenter study", World Journal of Urology, pp.10~1007 (2011)[DOI]
  8. Neveus T, "Nocturnal enuresis-theoretic background and practical guidelines", Pediatr Nephrol, 26, pp.1207~1214 (2011)
  9. Robertson G, "Pathophysiology and treatment of enuresis in adults", Scandinavian journal of urology and nephrology Supplementum, 202, pp.36~39 (1999)
  10. Poulton EM, "Relative nocturnal polyuria as a factor in enuresis", Lancet, 2, pp.906~907 (1952)
  11. Valenti G, "Urinary aquaporin 2 and calciuria correlate with the severity of enuresis in children", JASN, 11, pp.1873~1881 (2000)
  12. Kamperis K, "Urinary calcium excretion in healthy children and children with primary monosymptomatic nocturnal enuresis", The Journal of Urology, 176, pp.770~773 (2006)
  13. Simpson AB, "Diurnal variations in the rate of urine excretion for two hour intervals: some associated factors", Journal of Biological Chemistry, 1924, pp.16~ (1923)
  14. Weitzman RE, "The clinical physiology of water metabolism. Part III: The water depletion (hyperosmolar) and water excess (hyposmolar) syndromes", The Western Journal of Medicine, 132, pp.16~38 (1980)
  15. Ford P, "Volume regulation in cortical collecting duct cells: role of AQP2. Biology of the cell", under the auspices of the European Cell Biology Organization, 2005, pp.97, 687~697
  16. Bichet DG, "Nephrogenic diabetes insipidus", Advances in Chronic Kidney Disease, 13, pp.96~104 (2006)
  17. Rittig S, "The circadian defect in plasma vasopressin and urine output is related to desmopressin response and enuresis status in children with nocturnal enuresis", The Journal of Urology, 179, pp.2389~2395 (2008)
  18. Rittig S, "Abnormal diurnal rhythm of plasma vasopressin and urinary output in patients with enuresis", The American Journal of Physiology, 256(4), pp.664~671 (1989)
  19. Sakakibara R, "Moxibustion, an alternative therapy, ameliorated disturbed circadian rhythm of plasma arginine vasopressin and urine output in multiple system atrophy", Intern Med, 46, pp.1015~1018 (2007)
  20. Lackgren G, "Diurnal plasma vasopressin and urinary output in adolescents with monosymptomatic nocturnal enuresis", Acta Paediatr, 86, pp.385~390 (1997)
  21. Hunsballe JM, "The efficacy of DDAVP is related to the circadian rhythm of urine output in patients with persisting nocturnal enuresis", Clinical Endocrinology, 49, pp.793~801 (1998)
  22. Pomeranz A, "Night-time polyuria and urine hypo-osmolality in enuretics identified by nocturnal sequential urine sampling--do they represent a subset of relative ADH-deficient subjects?", Scandinavian Journal of Urology and Nephrology, 34, pp.199~202 (2000)
  23. AbdelFatah D, "Nocturnal polyuria and nocturnal arginine vasopressin (AVP): a key factor in the pathophysiology of monosymptomatic nocturnal enuresis", Neurourology and Urodynamics, 28, pp.506~509 (2009)
  24. Kamperis K, "Excess diuresis and natriuresis during acute sleep deprivation in healthy adults", American Journal of Physiology Renal Physiology, 299, pp.404~411 (2010)
  25. Kruse A, "Increased nocturnal blood pressure in enuretic children with polyuria", The Journal of Urology, 182(4), pp.1954~1960 (2009)
  26. Evans RA, "Hypercalcaemia. What does it signify?", Drugs, 31, pp.64~74 (1986)
  27. Pace G, "Nocturnal enuresis can be caused by absorptive hypercalciuria", Scandinavian Journal of Urology and Nephrology, 33, pp.111~114 (1999)
  28. Raes A, "Hypercalciuria is related to osmolar excretion in children with nocturnal enuresis", The Journal of Urology, 183, pp.297~301 (2010)
  29. Valenti G, "Low-calcium diet in hypercalciuric enuretic children restores AQP2 excretion and improves clinical symptoms", American Journal of Physiology Renal Physiology, 283, pp.895~903 (2002)
  30. Earm JH, "Decreased aquaporin-2 expression and apical plasma membrane delivery in kidney collecting ducts of polyuric hypercalcemic rats", JASN, 9, pp.2181~2193 (1998)
  31. Procino G, "Extracellular calcium antagonizes forskolin-induced aquaporin 2 trafficking in collecting duct cells", Kidney International, 66, pp.2245~2255 (2004)
  32. Bustamante M, "Calcium-sensing receptor attenuates AVP-induced aquaporin-2 expression via a calmodulin-dependent mechanism", JASN, 19, pp.109~116 (2008)
  33. Procino G, "Aquaporin 2 and apical calcium-sensing receptor: new players in polyuric disorders associated with hypercalciuria", Seminars in nephrology, 28, pp.297~305 (2008)
  34. Rittig S, "Diurnal variation of plasma atrial natriuretic peptide in normals and patients with enuresis nocturna", Scandinavian Journal of Clinical and Laboratory Investigation, 51, pp.209~217 (1991)
  35. Vurgun N, "Hypernatriuria and kaliuresis in enuretic children and the diurnal variation", The Journal of Urology, 159, pp.1333~1337 (1998)
  36. Kamperis K, "The effect of desmopressin on renal water and solute handling in desmopressin resistant monosymptomatic nocturnal enuresis", The Journal of Urology, 180, pp.707~714 (2008)
  37. Kuznetsova AA, "Osmoregulatory function of the kidney in enuretic children", Scandinavian Journal of Urology and Nephrology, 32, pp.132~137 (1998)
  38. Aceto G, "Enuresis subtypes based on nocturnal hypercalciuria: a multicenter study", The Journal of Urology, 170(4), pp.1670~1673 (2003)
  39. Rittig S, "Circadian variation of angiotensin II and aldosterone in nocturnal enuresis: relationship to arterial blood pressure and urine output", The Journal of Urology, 176, pp.774~780 (2006)
  40. Raes A, "Abnormal circadian rhythm of diuresis or nocturnal polyuria in a subgroup of children with enuresis and hypercalciuria is related to increased sodium retention during daytime", The Journal of Urology, 176, pp.1147~1151 (2006)
  41. De Guchtenaere A, "Desmopressin resistant nocturnal polyuria may benefit from furosemide therapy administered in the morning", The Journal of Urology, 178, pp.2635~2639 (2007)
  42. De Guchtenaere A, "Nocturnal polyuria is related to absent circadian rhythm of glomerular filtration rate", The Journal of Urology, 178, pp.2626~2629 (2007)

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