Effects of dandelion (Taraxacum sp.,) supplements on lactation performance, antioxidative activity, and plasma metabolome in primiparous dairy cows
3
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Objective: This study evaluated the effects of dandelion supplements on lactation performance, circulating antioxidative activity and plasma metabolomics in primiparous dairy cows. Methods: A total of 60 mid-lactation dairy cows (milk yield = 34.29±0.34 kg/d; days in milk = 151.72±2.36 days) were divided into 4 treatment groups randomly, comprising the addition of dandelion at 0, 100, 200, 400 g/d per head. The experiment lasted for 8 weeks with an extra 10 days’ pre-feeding period. Milk and blood samples were collected, and plasma samples were selected to perform metabolomics analysis. Results: Supplementing 200 g/d of dandelion increased the yield of milk and lactose (p≤ 0.05). The milk somatic cell counts (p≤0.05) were lower in all dandelion groups than those in the control group. The activity of glutathione peroxidase (p≤0.05) and superoxide dismutase (p≤0.05) were increased and plasma malondialdehyde (p = 0.01) was decreased when cows were fed 200 g/d dandelion. Plasma metabolomics analysis showed that 23 hub differential metabolites were identified in the 200 g/d dandelion group. These metabolites such as ribose, glutamic acid, valine, and phenylalanine were enriched in D-glutamine and D-glutamate metabolism (p = 0.06, impact value = 1), phenylalanine, tyrosine, and tryptophan biosynthesis (p = 0.05, impact value = 0.5), and starch and sucrose metabolism (p = 0.21, impact value = 0.13). Moreover, correlation analysis showed that circulating ribose, mannose, and glutamic acid were positively related to milk yield. Conclusion: Dandelion supplementation could improve lactation performance and elevate the plasma carbohydrate and amino acids metabolism and antioxidative activity. Supplementation of 200 g/d dandelion is recommended for lactating dairy cows.
Abstract
Objective: This study evaluated the effects of dandelion supplements on lactation performance, circulating antioxidative activity and plasma metabolomics in primiparous dairy cows. Methods: A total of 60 mid-lactation dairy cows (milk yield = 34.29±0.34 kg/d; days in milk = 151.72±2.36 days) were divided into 4 treatment groups randomly, comprising the addition of dandelion at 0, 100, 200, 400 g/d per head. The experiment lasted for 8 weeks with an extra 10 days’ pre-feeding period. Milk and blood samples were collected, and plasma samples were selected to perform metabolomics analysis. Results: Supplementing 200 g/d of dandelion increased the yield of milk and lactose (p≤ 0.05). The milk somatic cell counts (p≤0.05) were lower in all dandelion groups than those in the control group. The activity of glutathione peroxidase (p≤0.05) and superoxide dismutase (p≤0.05) were increased and plasma malondialdehyde (p = 0.01) was decreased when cows were fed 200 g/d dandelion. Plasma metabolomics analysis showed that 23 hub differential metabolites were identified in the 200 g/d dandelion group. These metabolites such as ribose, glutamic acid, valine, and phenylalanine were enriched in D-glutamine and D-glutamate metabolism (p = 0.06, impact value = 1), phenylalanine, tyrosine, and tryptophan biosynthesis (p = 0.05, impact value = 0.5), and starch and sucrose metabolism (p = 0.21, impact value = 0.13). Moreover, correlation analysis showed that circulating ribose, mannose, and glutamic acid were positively related to milk yield. Conclusion: Dandelion supplementation could improve lactation performance and elevate the plasma carbohydrate and amino acids metabolism and antioxidative activity. Supplementation of 200 g/d dandelion is recommended for lactating dairy cows.
참고문헌 (29)
- González-Castejón M, "Diverse biological activities of dandelion", Nutr Rev, 70, pp.534~547 (2012)[DOI]
- Cho SY, "Alternation of hepatic antioxidant enzyme activities and lipid profile in streptozotocininduced diabetic rats by supplementation of dandelion water extract", Clin Chim Acta, 317, pp.109~117 (2002)[DOI]
- Schütz K, "Taraxacum--a review on its phytochemical and pharmacological profile", J Ethnopharmacol, 107, pp.313~323 (2006)[DOI]
- Choi UK, "Hypolipidemic and antioxidant effects of dandelion(Taraxacum officinale)root and leaf on cholesterol-fed rabbits", Int J Mol Sci, 11, pp.67~78 (2010)[DOI]
- Mertenat D, "Ethnoveterinary knowledge of farmers in bilingual regions of Switzerland-is there potential to extend veterinary options to reduce antimicrobial use?", J Ethnopharmacol, 246, pp.112184~ (2020)[DOI]
- Hristov AN, "Special topics--Mitigation of methane and nitrous oxide emissions from animal operations : I. A review of enteric methane mitigation options", J Anim Sci, 91, pp.5045~5069 (2013)[DOI]
- Wang B, "Saponin-induced shifts in the rumen microbiome and metabolome of young cattle", Front Microbiol, 10, pp.356~ (2019)[DOI]
- Sun Z, "Perilla frutescens leaf alters the rumen microbial community of lactating dairy cows", Microorganisms, 7, pp.562~ (2019)[DOI]
- L. Yan, "Evaluation of Houttuynia cordata and Taraxacum officinale on Growth Performance, Nutrient Digestibility, Blood Characteristics, and Fecal Microbial Shedding in Diet for Weaning Pigs", Animal Bioscience, 25(10), pp.1439~1444 (2012), 아세아·태평양축산학회[DOI]
- Tan X, "Effects of dietary dandelion extract on intestinal morphology, antioxidant status, immune function and physical barrier function of juvenile golden pompano Trachinotus ovatus", Fish Shellfish Immunol, 73, pp.197~206 (2018)[DOI]
- Li Y, "Dandelion(Taraxacum mongolicum Hand. -Mazz. )supplementation-enhanced rumen fermentation through the interaction between ruminal microbiome and metabolome", Microorganisms, 9, pp.83~ (2020)[DOI]
- AOAC, "Official methods of analysis. Vol. I" (1990), Association of Official Analytical Chemists
- Van Soest PJ, "Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition", J Dairy Sci, 74, pp.3583~3597 (1991)[DOI]
- Wang B, "Effects of alfalfa and cereal straw as a forage source on nutrient digestibility and lactation performance in lactating dairy cows", J Dairy Sci, 97, pp.7706~7715 (2014)[DOI]
- Wang DM, "Effects of γ-aminobutyric acid on feed intake, growth performance and expression of related genes in growing lambs", Animal, 9, pp.445~448 (2015)[DOI]
- Zhao H, "Antioxidant and hepatoprotective activities of polysaccharides from spent mushroom substrates(Laetiporus sulphureus)in acute alcohol-induced mice", Oxid Med Cell Longev, 2017, pp.5863523~ (2017)[DOI]
- Valussi M, "Functional foods with digestion-enhancing properties", Int J Food Sci Nutr, 63(Suppl 1), pp.82~89 (2012)[DOI]
- Kitts DD, "Effect of dietary caffeic and chlorogenic acids on in vivo xenobiotic enzyme systems", Plant Foods Hum Nutr, 45, pp.287~298 (1994)[DOI]
- Hu C, "Luteolin and luteolin-7-O-glucoside from dandelion flower suppress iNOS and COX-2 in RAW264. 7cells", Mol Cell Biochem, 265, pp.107~113 (2004)[DOI]
- Bernabucci U, "Markers of oxidative status in plasma and erythrocytes of transition dairy cows during hot season", J Dairy Sci, 85, pp.2173~2179 (2002)[DOI]
- Draper HH, "Malondialdehyde determination as index of lipid peroxidation", Methods Enzymol, 186, pp.421~431 (1990)[DOI]
- Wang Y, "Increased superoxide generation is associated with decreased superoxide dismutase activity and mRNA expression in placental trophoblast cells in preeclampsia", Placenta, 22, pp.206~212 (2001)[DOI]
- Suksrichavalit T, "Copper complexes of pyridine derivatives with superoxide scavenging and antimicrobial activities", Eur J Med Chem, 44, pp.3259~3265 (2009)[DOI]
- Hultquist KM, "Effects of feeding rumen-degradable valine on milk production in late-lactating dairy cows", J Dairy Sci, 99, pp.1201~1215 (2016)[DOI]
- 김정은, "Phenylalanine and valine differentially stimulate milk protein synthetic and energy-mediated pathway in immortalized bovine mammary epithelial cells", 한국축산학회지, 62(2), pp.263~275 (2020), 한국축산학회[DOI]
- Wang F, "Amino acid metabolism in dairy cows and their regulation in milk synthesis", Current drug metabolism, 20, pp.36~45 (2019)[DOI]
- Long Guo, "Phenylalanine regulates initiation of digestive enzyme mRNA translation in pancreatic acinar cells and tissue segments in dairy calves", Bioscience Reports, 38(1) (2018), Portland Press Ltd.[DOI]
- Meijer GA, "Glutamine is a potentially limiting amino acid for milk production in dairy cows : a hypothesis", Metabolism, 42, pp.358~364 (1993)[DOI]
- Nemati M, "Effect of protected-glutamine supplementation on performance, milk composition and some blood metabolites in fresh Holstein cows", Iran J Vet Res, 19, pp.225~228 (2018)
