Renal Manifestations and Imaging Studies of Kawasaki Disease
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Purpose: The aim of this study was to verify renal inflammation following Kawasaki disease (KD) using single photon emission computed tomography along with Technetium-99m dimercaptosuccinic acid scintigraphy (DMSA renal SPECT). Methods: From March 2011 to October 2011, 15 patients diagnosed with KD at the National Health Insurance System Ilsan Hospital were enrolled in the study. All patients underwent DMSA renal SPECT to evaluate renal involvement during the acute phase of KD. Urine β2-microglobulin (β2-MG), a marker of renal proximal tubular dysfunction, was also measured to assess renal damage. Results: All 15 patients had normal renal function test results. However, microscopic hematuria and pyuria were observed in 13% and 33% of the patients, respectively. Moreover, urine β2-MG was elevated in 46% of the patients. In addition, patients were divided into two groups based on β2-MG level: those with an increased β2-MG level, and those with a normal β2-MG level. No significant differences were found between these two groups in clinical characteristics, laboratory,sonography, and echocardiography findings. All patients’ DMSA renal SPECT scans were normal. Conclusion: Our study showed that mild abnormalities in the urinalysis and elevated urine β2-MG were the only findings of renal involvement in KD. However,no aggressive renal manifestations were detected on DMSA renal SPECT.
Abstract
Purpose: The aim of this study was to verify renal inflammation following Kawasaki disease (KD) using single photon emission computed tomography along with Technetium-99m dimercaptosuccinic acid scintigraphy (DMSA renal SPECT). Methods: From March 2011 to October 2011, 15 patients diagnosed with KD at the National Health Insurance System Ilsan Hospital were enrolled in the study. All patients underwent DMSA renal SPECT to evaluate renal involvement during the acute phase of KD. Urine β2-microglobulin (β2-MG), a marker of renal proximal tubular dysfunction, was also measured to assess renal damage. Results: All 15 patients had normal renal function test results. However, microscopic hematuria and pyuria were observed in 13% and 33% of the patients, respectively. Moreover, urine β2-MG was elevated in 46% of the patients. In addition, patients were divided into two groups based on β2-MG level: those with an increased β2-MG level, and those with a normal β2-MG level. No significant differences were found between these two groups in clinical characteristics, laboratory,sonography, and echocardiography findings. All patients’ DMSA renal SPECT scans were normal. Conclusion: Our study showed that mild abnormalities in the urinalysis and elevated urine β2-MG were the only findings of renal involvement in KD. However,no aggressive renal manifestations were detected on DMSA renal SPECT.
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